DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and abcc6

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	XP_002932264.3	Gene:	abcc6 / 100493037	XenbaseID:	XB-GENE-6465366	Length:	1500	Species:	Xenopus tropicalis

Alignment Length:	1390	Identity:	444/1390 - (31%)
Similarity:	715/1390 - (51%)	Gaps:	188/1390 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDELKRSN---- 74
            |.::::|.|:.:|.|..::..||.:.||..|:::..||:..:|.:...|::..|.|.|::|
Frog   207 PVSESSFLSKVTFSWFTEIMFRGYKQPLKAEDVWSLRKSDTAEEILTLFSKGVEKECKKANLLKE 271

  Fly    75 -----PS-------------------------------VVRMILRAYGKIFVPMGLAFS------ 97
                 ||                               ::::|:|::|..|:...|..:
Frog   272 PTRFSPSTLDNDMWISQTEKSEIELLLKNQHIQLSQKTLLKVIMRSFGLYFLLSALLMTFYTAFL 336

  Fly    98 -ISETICKSLMPLFLGGLVGYFATNQTDISENT--AYLYAMGIVICMLVPVITFHPFIFYIFQVG 159
             ||..:.:.|:.|.            .|.|..:  .:|.|:.:.||.....:..|...:..:.:|
Frog   337 FISPLLVRLLLQLL------------KDPSAPSWQGFLVAVFLFICPCCQSLFLHQHDYICYVIG 389

  Fly   160 TKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGR-FDVALCFLHDTWKGPMESILIGF 223
            .:||.|:.|.:|:|.|.:|.:...:...|..:|::|.|:.: .|:|.| ::..|..|:..|:..:
Frog   390 MRLRAAIVGTVYKKALMISSAGRKESSAGEIVNLISTDVQKLMDLATC-VNYMWSAPVTIIVAMY 453

  Fly   224 LMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWE 288
            .:::.:||:.:.||:..:..:|.....|......::...::.|.|:|:::||:|||:|:|:||||
Frog   454 FLWQTLGIAVLAGVAVFILNLPFMTVFAVIIKRVQEQQMKQKDGRIKIISEILQGIKVLKLYAWE 518

  Fly   289 KSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISP-------LSVFLALCSYVYLGDPLTAQKV 346
            .:|.:.:.|.||.|:||::..|.:.:......:.||       ..|||||..    .:.|.|:|.
Frog   519 NAFMKKVTEFRLMELKAVKTGALLLSGALAVFVASPFWVSLTMFGVFLALDE----KNILDAEKA 579

  Fly   347 YTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPINLEANQQTGKNKRKIS 411
            :......|:|...:..| ||:||..|::.||.||...|.    .||   .||
Frog   580 FVTIILLNILRIPLRMF-PMAITLFAQSSVSLKRMVKFF----SAE---ELE------------- 623

  Fly   412 KKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWDTSDGHANCAIEDFSTDIK 476
                .::|::|.||                  :|..:.:::.:.:|.:|:  ..| ::..:..|.
Frog   624 ----PESVDINDSL------------------SKHAITIRHGTFTWSSSE--PPC-LQSINIGIP 663

  Fly   477 DQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNE 541
            ..||.||||.||.||:|.|:.||||:...:|:..:...::|..|::|:...|.::|::|.....:
Frog   664 QGTLVAVVGQVGCGKTSLLSALLGEMEKVEGQVSLMSSVAYVPQQTWIPNATFKENVLFGRKMEK 728

  Fly   542 RRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVD 606
            ..|.:||:.|.|..|:::|..|:.|.:||:||:||||||.|:|:||||||..|:|||||||||||
Frog   729 CWYDQVVQACALLPDLKILSGGENTEIGEKGVNLSGGQKQRISIARAVYRNCDVYLLDDPLSAVD 793

  Fly   607 THVGKHIFDRCI--RDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQE-LQRSRQFQF 668
            .|||:|:|::.|  ...|.:|.|:||||.|.:|..::.:::|..|::...|:|.| ||::..|..
Frog   794 AHVGQHLFEQVIGPSGLLKDKTRVLVTHGVSFLPQMDMIIVMSDGRVSEVGTYNELLQKNGAFSE 858

  Fly   669 LEQTQHDESGIDTHSVSSYLSRS-DSEKSMEHQHNQLLRPDEHVEDVNQEQQT------------ 720
            ...|...:|.:...|.......| .....|:.:|:.....|...:||..|.:.
Frog   859 FLNTYARKSVVFEESYEEQTPNSIQGAMKMKGKHSARNDTDNETDDVANEIEADAGKLTEADVAL 923

  Fly   721 VGSIKMHVYASYIKALDSTFLLGIVISLFVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNET 785
            .|.:|:.||..|.|.:...:|| |....|:..:......:|::..|.
Frog   924 TGRVKLSVYLEYCKIMGKWYLL-ISALFFIVQQAASLSYNYWIGLWA------------------ 969

  Fly   786 DTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILGATLIVYLIRTFGFFKMCLRISL 850
                  |..|:|.|..:.:..|......|:.|.|.:|.|:   :|:||..:          .:|.
Frog   970 ------DDPPVNGTQQHTSLRLGVYSFLGVMQALSIFAAS---STIIVGGV----------SVSR 1015

  Fly   851 HLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCLAFIIDVSGVVIIVAIA 915
            .||.||...|.|..:.||....||.:.|||:|::..:|..:|..|:..:..::.::.::::::||
Frog  1016 QLHSRLLYSILRCPLSFFERTPSGNLTNRFAKEMDIIDNTVPQVLMLFIIMMLTIAEILLVISIA 1080

  Fly   916 NYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQ 980
            .....:....:|::...::..||.:||.:|||:::|:||:::..|::.||:..|||.:.|....|
Frog  1081 TPLAAVAFIPLGLLYFFLQRFYVASSRQLKRLDAVSKSPLYTHFNESLQGVYVIRAFREQERFIQ 1145

  Fly   981 EFHEYQNTNTSAWFLFLSCTRAFALWSDVLC------IVYMTAVTFSFLLLKDEFDSGDVGLAIL 1039
            :.:...|.|...:|    |:.....|..|.|      ||:..|:.  .:|.:|....|.||||::
Frog  1146 DNNMRLNMNQRFYF----CSFVANRWLSVRCDFLSNFIVFTVAIV--GVLFRDNITPGLVGLAVV 1204

  Fly  1040 HSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETPEKFKPKSEWPSKGRIEFINFK 1104
            :|..:||:.:..:....::|....|||||.||.:...||.. |.:.....|.|||||:|||.|:.
Frog  1205 NSLRLTGVLKEAVHVATDMETNSVSVERVKEYCDAEPEAPW-TSDNASDLSNWPSKGKIEFQNYG 1268

  Fly  1105 LRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFR-LACNEGMIRIDDVDIEHIGLH 1168
            |||.|.....||::..:|:..||:||||||||||||:...:|| |....|.|.||:.||..:|||
Frog  1269 LRYRPDLDLALKNVTASIQQGEKVGIVGRTGAGKSSLTLGLFRILEPATGRICIDEKDISELGLH 1333

  Fly  1169 DLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSN 1233
            :|||:::||||||||||||||.||||.|..||.::|.||....|:.:.|.|..||:....:||.|
Frog  1334 ELRSKITIIPQDPVLFSGTLRMNLDPFDNYSDNDIWVALQLAHLKVFASGLPEGLSYICTEGGEN 1398

  Fly  1234 FSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDS 1298
            .|||||||||||||:||..|||::|||||.||.|||.|||.|||.:|..||::||||||:|:||.
Frog  1399 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQNTIRKEFEDCTIITIAHRLNTIMDY 1463

  Fly  1299 DRVLVMDAGEVRELGHPYELLQRTG 1323
            .||:|.|.||:.|...|..||:..|
Frog  1464 TRVVVFDKGEIVEFDTPATLLENKG 1488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	444/1390 (32%)
		ABC_membrane	94..360	CDD:294371	71/282 (25%)
		ABCC_MRP_domain1	448..650	CDD:213217	82/203 (40%)
		ABC_membrane	821..1046	CDD:294371	62/230 (27%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	126/219 (58%)
abcc6	XP_002932264.3	MRP_assoc_pro	5..1499	CDD:188098	444/1390 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010