DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and abcc4

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	XP_002939329.2	Gene:	abcc4 / 100491006	XenbaseID:	XB-GENE-957302	Length:	1324	Species:	Xenopus tropicalis

Alignment Length:	1375	Identity:	534/1375 - (38%)
Similarity:	823/1375 - (59%)	Gaps:	100/1375 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PK----NPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDELK 71
            ||    ||...|||.|:..|||:..||..|.:..|.::::|:......|.::..:....||.||:
Frog     5 PKGSKANPSQHANFCSKIFFWWLNPLFILGHKRKLEEDDMYEVLPEDASRKLGEELQWYWEKELQ 69

  Fly    72 RS-----NPSVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYFA---TNQTDISEN 128
            ::     .|.:.:.|:|.:.|.|..:|| |:..|...:.:.|:|||.::.||.   .|.:.:..|
Frog    70 KAQNEGRKPRLTKAIIRCHWKTFSVLGL-FTFFEESIRVVQPIFLGNVISYFERYDANDSAVLAN 133

  Fly   129 TAYLYAMGIVICMLVPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINI 193
             ||:.|..:..|.|:..:..|.:.:::.:.|.|||:|:..:||||.|::|.::......|:.:|:
Frog   134 -AYINAAALSACTLILAVVHHIYFYHLLRAGMKLRVAMCHMIYRKALRLSNTAMGKTTTGQIVNL 197

  Fly   194 LSNDLGRFDVALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYR 258
            ||||:.:||....|||..|.||:::|.:..|::.|||.|.:.|::.::..:|||....|.....|
Frog   198 LSNDVNKFDQVTIFLHFLWAGPLQAIAVTVLLWMEIGPSCLAGMAVLIILMPLQLCLGKFFTSLR 262

  Fly   259 QMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAA-LGCTSMI 322
            ..||..||.|::.|||:|.|:::|||||||:||..::..:|.||:..:..::|:.|. |....:.
Frog   263 GKTAAFTDTRIRTMNEVISGMRIIKMYAWEQSFTELVNNIRKKEINKVLRSSYLRALNLASFFVA 327

  Fly   323 SPLSVFLALCSYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLD 387
            |.:.:|:...:||.||:.::|.:|:...|.::.:..::..|:|.::...:||.||.:|.|:|||.
Frog   328 SKIILFVTFTTYVLLGNVISASRVFVAVSLYSAVRLTVTLFFPSAVERASEAKVSIRRIKNFLLL 392

  Fly   388 GDKAEVPINL-EANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLK 451
            .:..:..:.| |.|::                     :||                     |.::
Frog   393 DEIFKPALELPEENEE---------------------NLL---------------------VQIQ 415

  Fly   452 NVSASWDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKIS 516
            :|:..||.:  .....:::.|..::...|.||:|||||||||.|:.:|||:..|||...:.|:|:
Frog   416 DVTCYWDKT--LEIPTLQNISCSVRPGELLAVIGPVGAGKSSLLSAVLGELPKDKGFVDIRGRIA 478

  Fly   517 YASQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKA 581
            |.||:.|||.||:|.||:|.::|.:.:|.||::||.|::||..|..||||::|:|||:|||||||
Frog   479 YVSQQPWVFSGTVRSNILFGKEYVQEKYDKVLRVCALKKDMLQLDDGDLTIIGDRGVTLSGGQKA 543

  Fly   582 RVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSNKIRILVTHQVQYLFDVEHLLLM 646
            ||:||||||:.||||||||||||||..||:|:|::||...|..|:.||||||:|||...:.:|::
Frog   544 RVNLARAVYQDADIYLLDDPLSAVDAEVGRHLFEKCICQALRKKLCILVTHQLQYLSAAKQILIL 608

  Fly   647 GSGKIMAQGSYQE-LQRSRQFQFL------EQTQHDESGI------DTHSVSSYLSRSDSEKSME 698
            ..|:::.:|::|| ||....|..|      ||:|..|..:      .|.|.||..|:..:.:|.:
Frog   609 KEGRMVGKGTFQELLQSGIDFASLLKSEEEEQSQSQEGQLIKSSRNRTFSQSSVWSQDSTVQSHK 673

  Fly   699 HQHNQLLRPDEHVEDVNQEQQTVGSIKMHVYASYIKALDSTFLLGIVISLFVCARIMLTGVDYFL 763
            ......|..:..:..:.:|.::.|::...||..|..:..|..:|.:|:.|.:.:::.....|::|
Frog   674 EGATDNLAAEPVLTAIPEESRSEGTVGFKVYKKYFTSGSSYLMLFVVLLLNILSQVTYVLQDWWL 738

  Fly   764 SRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILG 828
            |.|.  .||..:|.|    :.|::| .:.|..::.|           :..|:       ||.:..
Frog   739 SYWA--NEQGKLNIT----SGTNST-GSKTEQLDLT-----------LYLGV-------YAGLTV 778

  Fly   829 ATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPH 893
            ||:|..::|....|.:.:..:..||:::|:.:.:|.:.||:.|..|||||||||||..:|..:|.
Frog   779 ATIIFGVLRCLLVFHVLVCAAQALHNQMFQSLLKAPVLFFDRNPIGRILNRFSKDIGHLDDLMPF 843

  Fly   894 TLLDCLAFIIDVSGVVIIVAIANYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSL 958
            |.||.:..::.:.||:.:......|:|||...:.::...:|..:::|||.:|||||.:||||||.
Frog   844 TFLDFMQVLLQILGVIAVAVAVIPWILIPLLPLVIVFYFLRRYFLDTSRDIKRLESTTRSPVFSH 908

  Fly   959 TNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDVLCIVYMTAVTFSFL 1023
            .:.:.|||.||||.:|:...:..|...|:.::.||||||:.:|..|:..|.:|.|::.|:.|..:
Frog   909 LSSSLQGLWTIRAFKAEKRFQDLFDAQQDLHSEAWFLFLTTSRWLAVRLDAICAVFVIAIAFGSI 973

  Fly  1024 LLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETPEKFKP 1088
            :|.:..|:|.||||:.:..|:.|..|||:||:||:||.|.|.|||:|||:...||  |...|..|
Frog   974 ILAENLDAGQVGLALSYGMTIMGSFQWGVRQSAEVENLMISAERVMEYTQLEKEA--EWESKNPP 1036

  Fly  1089 KSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRLACNEG 1153
            .::||:||.|.|.|....||.....||:.||..|.|:||:||||||||||||:|.::||||..||
Frog  1037 PADWPNKGMITFENVNFSYSLDGPVVLRHLNALIRPKEKVGIVGRTGAGKSSLIAALFRLAEPEG 1101

  Fly  1154 MIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVST 1218
            .|.||......:||||||.::|||||:||||:||:|.||||.||.:|||:|..|.:|:|:..|..
Frog  1102 KIWIDKYLTSKLGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFDEHADEELWDVLEEVQLKEAVEE 1166

  Fly  1219 LIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHC 1283
            |.|.:..::.:.||||||||||||||||||||.|:|||:|||||||||.||:|||:|||.|||.|
Frog  1167 LPGKIETQLSESGSNFSVGQRQLVCLARAILRRNRILIIDEATANVDPRTDELIQKTIREKFAEC 1231

  Fly  1284 TVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLRQLVDNTGAATSFALQQAAEQS 1348
            |||||||||:|::|||:::|:|||.|:|...||.|||.......::|...|.|.:.||.:||:|.
Frog  1232 TVLTIAHRLNTIIDSDKIMVLDAGRVKEYDEPYLLLQNKESLFYKMVQQVGKAEATALNEAAKQV 1296

  Fly  1349 YSKQILGDDT 1358
            |.|:|..::|
Frog  1297 YLKKIHQENT 1306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	526/1357 (39%)
		ABC_membrane	94..360	CDD:294371	88/269 (33%)
		ABCC_MRP_domain1	448..650	CDD:213217	103/201 (51%)
		ABC_membrane	821..1046	CDD:294371	82/224 (37%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	134/218 (61%)
abcc4	XP_002939329.2	PLN03130	2..1289	CDD:215595	525/1356 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9436
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1027	1.000	Inparanoid score	I277
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm47437
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160