DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and abcc2

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	XP_004915926.1	Gene:	abcc2 / 100485020	XenbaseID:	XB-GENE-1012796	Length:	1552	Species:	Xenopus tropicalis

Alignment Length:	1444	Identity:	480/1444 - (33%)
Similarity:	735/1444 - (50%)	Gaps:	227/1444 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDELK----- 71
            :||...|:|.|:.:|.|...:..:|.:.||..|:|::    |:.|..|....|::|..:|
Frog   201 ENPELTASFLSRITFNWYNSIVVKGYKKPLEMEDLWE----LNEEDKTKNMYEIFEKHMKHDVRK 261

  Fly    72 ------------RSNPSVVRM----------IL--------------------RAYGKIFVPMGL 94
                        :...|.:.|          ||                    :.|.|.::...|
Frog   262 AKKDLEKRKNKRKQKESGIEMNGISKAQSQDILVMEEKKKEKKKKEKSIDGTAKDYPKRWLIKTL 326

  Fly    95 AFSISETICKSLMPLFLGGLVGY--------FATNQTDISEN--TAYLYAMGIVICMLVPVITFH 149
            ..:...|:..|.:...|..|:.:        ..|...|.|::  ..:.||:.:::..|:......
Frog   327 IKTFPSTLLTSAIFKLLHDLLAFVSPQILKVMVTFTADPSQHQWQGFFYAVLLLVTALLQSFLLQ 391

  Fly   150 PFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDVALCFLHDTWKG 214
            .:....|.:|.::|..|...:|:|.|.||.:...:...|..:|::|.|..||.....|:|..|..
Frog   392 QYFHGCFVLGMRVRSLLMAAVYKKALTVSNAIRKESTVGETVNLMSADAQRFMDLTNFIHLLWSS 456

  Fly   215 PMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGI 279
            |::..:....::.|:|.|.:.|:..|:..||:.|..|..:...:....:..|.|:|:||||:.||
Frog   457 PLQIAISIVFLWEELGPSVLAGLGVMILLIPINAVLATVSRKLQMKNMKNKDKRMKIMNEILNGI 521

  Fly   280 QVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISPLSVFLALCSYVYLGDP---L 341
            :::|:||||.||...:.|:|.||:|.:....|:|:........:|..|.:|..:.....||   |
Frog   522 KILKLYAWEPSFENQVQEIREKELKDMLHFTYLHSVSLFVFTCAPFLVSVATFAVYVAVDPSNVL 586

  Fly   342 TAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFL----LDGDKAEVPINLEANQQ 402
            .|:|.:|..|.||:|...:... ||.|:.:.:..||:.|.:.:|    ||........|::|
Frog   587 NAEKAFTSISLFNILRFPLAML-PMLISSMVQTSVSSARLEKYLGGDNLDTSAIRCDPNIDA--- 647

  Fly   403 TGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWDTSDGHANCA 467
                                                        .|...:.:.||:..   ||.|
Frog   648 --------------------------------------------AVQFSDATFSWEED---ANPA 665

  Fly   468 IEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDN 532
            :.:.:.|||:..|.||||.||:||||.::.:|||:....|...:.|.|:|..|::|:...|:::|
Frog   666 VNNVNLDIKEGNLVAVVGGVGSGKSSLVSAMLGEMDHVGGYINIKGSIAYVPQQAWIQNATLKNN 730

  Fly   533 IVFVEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYL 597
            |:|....:|.||:||::.|.|..|:|:||..|.:.:||:|::||||||.|||||||||..||||:
Frog   731 ILFGSKMDEERYQKVLEACALLPDLEMLPGHDESEIGEKGINLSGGQKQRVSLARAVYNDADIYI 795

  Fly   598 LDDPLSAVDTHVGKHIFDRCI--RDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQEL 660
            |||||||||.|||||||::.:  ...|.||.||||||.|.:|...:.::::.:.::...|||:.|
Frog   796 LDDPLSAVDAHVGKHIFEKVVGPNGLLKNKTRILVTHGVSFLKHADDIVVLVNSRVTETGSYKTL 860

  Fly   661 QRSR----QFQFLEQTQHDE--------SGIDTHS--------------VSSYLSRSDSEKSMEH 699
            |.:.    :|..|...|:|:        :|.|...              |:|.:.|.:|.:..:.
Frog   861 QANNGAFAEFLRLYAKQNDQTDNEATVFTGEDDEDDGDQVETAEVIEDIVASTVKRENSMRQRKR 925

  Fly   700 QH---NQLLRPDEHVEDVNQ----------------EQQTV--GSIKMHVYASYIKALDSTFLLG 743
            ..   |..||  ..|:||.:                |::||  |.:|..:|..|::|:...|...
Frog   926 SSVSMNGTLR--RSVKDVTKKKTGIGSNDTKGQKLIEKETVETGKVKFKLYLKYLRAVGWGFSFW 988

  Fly   744 IVISLFVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLA 808
            |.:| ::.......|.:.:||.|....|:                ..|.|.|.:..|..:....|
Frog   989 IFVS-YILQNAAFVGQNIWLSDWTGDAEK----------------YYNITYPASQRDMRVGVFGA 1036

  Fly   809 SDIQAGIRQELVLFYATILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSS 873
                .|:.|.|.:    :|||.|:     :.|    .:|.|..||.:|...|.|..|.||:|..:
Frog  1037 ----LGVAQALFV----LLGAFLV-----SGG----AVRASRMLHTQLLHNILRVPMRFFDTTPT 1084

  Fly   874 GRILNRFSKDIRTVDTDLPHTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAII---GVILGMIRY 935
            |||:|||:|||.|||..:|.:....:|..:.|.|.:.|:.:|.   .|.||:|   .:....::.
Frog  1085 GRIVNRFAKDILTVDETIPMSFRSWIACFLGVIGTLFIICLAT---PIFAAVIVPLAIFYYFVQR 1146

  Fly   936 LYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCT 1000
            .||.|||.::||:|::|||::|...:|..||:.|||...|....|...:..:.|..:.:.::...
Frog  1147 FYVTTSRQLRRLDSVTRSPIYSHFGETVSGLSVIRAYGHQDRFLQHNEDTIDNNQKSVYSWIVSN 1211

  Fly  1001 RAFALWSDVL--CIVYMTAVTFSFLLL-KDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQM 1062
            |..|:..:.:  ..|:..|:   |.:| :...|||.|||:|..:..:|....|.:|.|:|||..:
Frog  1212 RWLAIRLEFVGNLTVFFAAL---FAVLGRGTVDSGTVGLSISSALNITQTLNWLVRMTSELETNI 1273

  Fly  1063 TSVERVLEYTEQPSEALLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREK 1127
            .:||||.||.:...||  :..|..:|..:||.||.::|:::|:||.|:...||:.::.||...||
Frog  1274 VAVERVDEYIKVEREA--QWVEDHRPPKDWPEKGVVQFVDYKVRYRPELDLVLQGISCTINSMEK 1336

  Fly  1128 IGIVGRTGAGKSSIIQSIFRLACNE-GMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYN 1191
            :||||||||||||:...|||:..:. |.|.||.:||..|||||||.:::|||||||||||.||.|
Frog  1337 VGIVGRTGAGKSSLTNCIFRIIESAGGKIMIDGLDIASIGLHDLRQKLTIIPQDPVLFSGNLRMN 1401

  Fly  1192 LDPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMY----DGGSNFSVGQRQLVCLARAILRHN 1252
            |||.::.:||::||||   || |::...:.||..:::    :||.|.|||||||||||||:||.:
Frog  1402 LDPFNQYTDEDIWKAL---EL-SHLKPFVEGLQEKLFHEVSEGGENLSVGQRQLVCLARALLRKS 1462

  Fly  1253 KILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYE 1317
            ||||:|||||.||.|||.|||:||||:||.||||||||||||:|||.|::|:|||::.|.|.|.|
Frog  1463 KILILDEATAAVDLETDNLIQRTIRSEFADCTVLTIAHRLHTIMDSSRLMVLDAGKIIEFGSPDE 1527

  Fly  1318 LLQRTGGYLRQLVD 1331
            ||||.|.:.....|
Frog  1528 LLQRQGHFFSMAKD 1541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	480/1444 (33%)
		ABC_membrane	94..360	CDD:294371	75/278 (27%)
		ABCC_MRP_domain1	448..650	CDD:213217	94/203 (46%)
		ABC_membrane	821..1046	CDD:294371	72/230 (31%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	131/223 (59%)
abcc2	XP_004915926.1	MRP_assoc_pro	10..1544	CDD:188098	480/1444 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930