Protein Alignment rdog and abcc2

DIOPT Version :10

• Sequence 1: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: XP_004915926.1
• Gene: abcc2 / 100485020
• XenbaseID: XB-GENE-1012796
• Length: 1552
• Species: Xenopus tropicalis
• Alignment Length: 1444
• Identity: 480/1444 - (33%)
• Similarity: 735/1444 - (50%)
• Gaps: 227/1444 - (15%)

  Fly    12 KNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDELK----- 71
            :||...|:|.|:.:|.|...:..:|.:.||..|:|::    |:.|..|....|::|..:|
 Frog   201 ENPELTASFLSRITFNWYNSIVVKGYKKPLEMEDLWE----LNEEDKTKNMYEIFEKHMKHDVRK 261

  Fly    72 ------------RSNPSVVRM----------IL--------------------RAYGKIFVPMGL 94
                        :...|.:.|          ||                    :.|.|.::...|
 Frog   262 AKKDLEKRKNKRKQKESGIEMNGISKAQSQDILVMEEKKKEKKKKEKSIDGTAKDYPKRWLIKTL 326

  Fly    95 AFSISETICKSLMPLFLGGLVGY--------FATNQTDISEN--TAYLYAMGIVICMLVPVITFH 149
            ..:...|:..|.:...|..|:.:        ..|...|.|::  ..:.||:.:::..|:......
 Frog   327 IKTFPSTLLTSAIFKLLHDLLAFVSPQILKVMVTFTADPSQHQWQGFFYAVLLLVTALLQSFLLQ 391

  Fly   150 PFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDVALCFLHDTWKG 214
            .:....|.:|.::|..|...:|:|.|.||.:...:...|..:|::|.|..||.....|:|..|..
 Frog   392 QYFHGCFVLGMRVRSLLMAAVYKKALTVSNAIRKESTVGETVNLMSADAQRFMDLTNFIHLLWSS 456

  Fly   215 PMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGI 279
            |::..:....::.|:|.|.:.|:..|:..||:.|..|..:...:....:..|.|:|:||||:.||
 Frog   457 PLQIAISIVFLWEELGPSVLAGLGVMILLIPINAVLATVSRKLQMKNMKNKDKRMKIMNEILNGI 521

  Fly   280 QVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISPLSVFLALCSYVYLGDP---L 341
            :::|:||||.||...:.|:|.||:|.:....|:|:........:|..|.:|..:.....||   |
 Frog   522 KILKLYAWEPSFENQVQEIREKELKDMLHFTYLHSVSLFVFTCAPFLVSVATFAVYVAVDPSNVL 586

  Fly   342 TAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFL----LDGDKAEVPINLEANQQ 402
            .|:|.:|..|.||:|...:... ||.|:.:.:..||:.|.:.:|    ||........|::|
 Frog   587 NAEKAFTSISLFNILRFPLAML-PMLISSMVQTSVSSARLEKYLGGDNLDTSAIRCDPNIDA--- 647

  Fly   403 TGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWDTSDGHANCA 467
                                                        .|...:.:.||:..   ||.|
 Frog   648 --------------------------------------------AVQFSDATFSWEED---ANPA 665

  Fly   468 IEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDN 532
            :.:.:.|||:..|.||||.||:||||.::.:|||:....|...:.|.|:|..|::|:...|:::|
 Frog   666 VNNVNLDIKEGNLVAVVGGVGSGKSSLVSAMLGEMDHVGGYINIKGSIAYVPQQAWIQNATLKNN 730

  Fly   533 IVFVEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYL 597
            |:|....:|.||:||::.|.|..|:|:||..|.:.:||:|::||||||.|||||||||..||||:
 Frog   731 ILFGSKMDEERYQKVLEACALLPDLEMLPGHDESEIGEKGINLSGGQKQRVSLARAVYNDADIYI 795

  Fly   598 LDDPLSAVDTHVGKHIFDRCI--RDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQEL 660
            |||||||||.|||||||::.:  ...|.||.||||||.|.:|...:.::::.:.::...|||:.|
 Frog   796 LDDPLSAVDAHVGKHIFEKVVGPNGLLKNKTRILVTHGVSFLKHADDIVVLVNSRVTETGSYKTL 860

  Fly   661 QRSR----QFQFLEQTQHDE--------SGIDTHS--------------VSSYLSRSDSEKSMEH 699
            |.:.    :|..|...|:|:        :|.|...              |:|.:.|.:|.:..:.
 Frog   861 QANNGAFAEFLRLYAKQNDQTDNEATVFTGEDDEDDGDQVETAEVIEDIVASTVKRENSMRQRKR 925

  Fly   700 QH---NQLLRPDEHVEDVNQ----------------EQQTV--GSIKMHVYASYIKALDSTFLLG 743
            ..   |..||  ..|:||.:                |::||  |.:|..:|..|::|:...|...
 Frog   926 SSVSMNGTLR--RSVKDVTKKKTGIGSNDTKGQKLIEKETVETGKVKFKLYLKYLRAVGWGFSFW 988

  Fly   744 IVISLFVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLA 808
            |.:| ::.......|.:.:||.|....|:                ..|.|.|.:..|..:....|
 Frog   989 IFVS-YILQNAAFVGQNIWLSDWTGDAEK----------------YYNITYPASQRDMRVGVFGA 1036

  Fly   809 SDIQAGIRQELVLFYATILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSS 873
                .|:.|.|.:    :|||.|:     :.|    .:|.|..||.:|...|.|..|.||:|..:
 Frog  1037 ----LGVAQALFV----LLGAFLV-----SGG----AVRASRMLHTQLLHNILRVPMRFFDTTPT 1084

  Fly   874 GRILNRFSKDIRTVDTDLPHTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAII---GVILGMIRY 935
            |||:|||:|||.|||..:|.:....:|..:.|.|.:.|:.:|.   .|.||:|   .:....::.
 Frog  1085 GRIVNRFAKDILTVDETIPMSFRSWIACFLGVIGTLFIICLAT---PIFAAVIVPLAIFYYFVQR 1146

  Fly   936 LYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCT 1000
            .||.|||.::||:|::|||::|...:|..||:.|||...|....|...:..:.|..:.:.::...
 Frog  1147 FYVTTSRQLRRLDSVTRSPIYSHFGETVSGLSVIRAYGHQDRFLQHNEDTIDNNQKSVYSWIVSN 1211

  Fly  1001 RAFALWSDVL--CIVYMTAVTFSFLLL-KDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQM 1062
            |..|:..:.:  ..|:..|:   |.:| :...|||.|||:|..:..:|....|.:|.|:|||..:
 Frog  1212 RWLAIRLEFVGNLTVFFAAL---FAVLGRGTVDSGTVGLSISSALNITQTLNWLVRMTSELETNI 1273

  Fly  1063 TSVERVLEYTEQPSEALLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREK 1127
            .:||||.||.:...||  :..|..:|..:||.||.::|:::|:||.|:...||:.::.||...||
 Frog  1274 VAVERVDEYIKVEREA--QWVEDHRPPKDWPEKGVVQFVDYKVRYRPELDLVLQGISCTINSMEK 1336

  Fly  1128 IGIVGRTGAGKSSIIQSIFRLACNE-GMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYN 1191
            :||||||||||||:...|||:..:. |.|.||.:||..|||||||.:::|||||||||||.||.|
 Frog  1337 VGIVGRTGAGKSSLTNCIFRIIESAGGKIMIDGLDIASIGLHDLRQKLTIIPQDPVLFSGNLRMN 1401

  Fly  1192 LDPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMY----DGGSNFSVGQRQLVCLARAILRHN 1252
            |||.::.:||::||||   || |::...:.||..:::    :||.|.|||||||||||||:||.:
 Frog  1402 LDPFNQYTDEDIWKAL---EL-SHLKPFVEGLQEKLFHEVSEGGENLSVGQRQLVCLARALLRKS 1462

  Fly  1253 KILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYE 1317
            ||||:|||||.||.|||.|||:||||:||.||||||||||||:|||.|::|:|||::.|.|.|.|
 Frog  1463 KILILDEATAAVDLETDNLIQRTIRSEFADCTVLTIAHRLHTIMDSSRLMVLDAGKIIEFGSPDE 1527

  Fly  1318 LLQRTGGYLRQLVD 1331
            ||||.|.:.....|
 Frog  1528 LLQRQGHFFSMAKD 1541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	MRP_assoc_pro	14..1323	CDD:188098	477/1432 (33%)
abcc2	XP_004915926.1	MRP_assoc_pro	10..1544	CDD:188098	480/1444 (33%)