DRSC/TRiP Functional Genomics Resources

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Protein Alignment rdog and abcc8b

DIOPT Version :9

Sequence 1:NP_651678.1 Gene:rdog / 43450 FlyBaseID:FBgn0039644 Length:1374 Species:Drosophila melanogaster
Sequence 2:XP_021323602.1 Gene:abcc8b / 100329706 ZFINID:ZDB-GENE-120215-45 Length:1607 Species:Danio rerio


Alignment Length:1449 Identity:419/1449 - (28%)
Similarity:707/1449 - (48%) Gaps:220/1449 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 VRPKNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAEL---WEDEL 70
            ||...||  .|..|:.::|||........|.|:   :|....|...|.|..:.|.:|   ::.::
Zfish   230 VRFLQPF--VNLLSKSTYWWMNTFITSAHQRPI---DLKTIGKLPKSMRALSNFQQLRKAFDSQM 289

  Fly    71 K------RSNPSVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYFATN-------- 121
            :      :.:..:.|.:.:|:|...: :.:.|.....:.....||.:.|::.:.:.:        
Zfish   290 ESGCVHLQGSGWMWRALRQAFGAPLL-LSICFRFISDLLGFAGPLCISGILQHISRDNHTAPPPV 353

  Fly   122 --------QTDISENTAYLYAMGIVICMLVPVITFHPFIFYI-FQVGTKLRLALSGLIYRKVLQV 177
                    .:::....||:.|:.:.:.:|:. .||....:|: .:.|..||.|:...||.|::::
Zfish   354 KLLGVHFISSEVFFANAYVLAVLLFLALLLQ-RTFLQASYYVAIENGINLRGAVQTKIYNKIMRL 417

  Fly   178 --SKSSSNDGLRGRAINILSNDLGRFDVALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFM 240
              |..|..|....:..|:::.|..:.........:.|..|::.::...|:|..:|.||:||.:.:
Zfish   418 CTSNMSMGDMTTAQICNLVARDTNQLMWFFFLCPNLWAMPVQIVIGVLLLYYLLGASALIGATVI 482

  Fly   241 LSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKA 305
            ....|||.:.|.:.:..::.|.|.|..|:|..||:::||:::|:||||..|...:.|.|.:|:.:
Zfish   483 TVLAPLQYFVATRLSRAQKSTLEYTSERLKKTNELLRGIKLLKLYAWEHIFRSSVEETRRQELTS 547

  Fly   306 IRGTA-------YIHAALGCTSM-----------------ISPLSVFLALCSYVYLGDPLTAQKV 346
            :|..|       :::||:...::                 :||...|.:|..:..|..||     
Zfish   548 LRTFALYTSLSIFMNAAIPIAAVLTIFVVHVHLQSSSDFALSPAVAFGSLSLFHILVTPL----- 607

  Fly   347 YTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFL----LDGDK---AEVPINLEAN---- 400
            :.:||   :|:.::            :||||.::..:||    ::.|:   |:.|.|...|    
Zfish   608 FLLSS---VLHSTV------------KALVSVQKLSEFLSSAEIETDQDPIAQTPANNNGNIKSV 657

  Fly   401 ---QQTGK--NKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWDTS 460
               |...|  |::..:|:|..:|.|.....|.....|.:.:          |:.:.|...||.  
Zfish   658 YALQLQAKLVNRKNKAKQDVNRNFEQQDQELRASAQHEDNI----------CIKIVNGYFSWT-- 710

  Fly   461 DGHANC-AIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKG--------------EAM 510
               ..| .:.:....:....|..:||.||:||||.|...|||:....|              ...
Zfish   711 ---QGCPTLTNIDIKVPFGQLTMIVGQVGSGKSSLLLAALGEMQKISGSITWNSLPRSDSDENIR 772

  Fly   511 VH-----------GKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRGD 564
            .|           |.::||||..|:...|:.:||:|....|.:|||.|::||.|..|::.||:||
Zfish   773 AHDMSGRQSFTRRGSVAYASQRPWLLNATVEENILFDTAPNVKRYKDVIEVCQLGPDIDTLPQGD 837

  Fly   565 LTVVGER----GVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSNK 625
            .||:|||    |:.|||||:.|:|:|||:|::.::..||||.||:|.|:..|:....|..||..:
Zfish   838 QTVIGERVRHLGIILSGGQRQRISVARALYQQTNVVFLDDPFSALDIHLSDHLMHEGILKFLRQE 902

  Fly   626 IR--ILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQRS-----RQFQFLEQTQHDESGIDTHS 683
            .|  :||||::|||...:.::.|..|.:..||:.:::|.:     .|::.|...|..|:      
Zfish   903 KRSVVLVTHKLQYLPHADWIIAMRDGTVQTQGTLKDIQCAEPELFEQWRTLMNRQDKEN------ 961

  Fly   684 VSSYLSRSDSEKSMEHQHNQLLRPDE-HVEDV----------NQEQQTVGSIKMH-------VYA 730
             |:.|.|....::|.:..:.:...|| .|.||          :.::.::|:...|       .:|
Zfish   962 -STELKRKSFRRAMMYSRDTVATDDEDEVADVAVSEVKDSSTSTDEDSLGAELRHRTTIPWSSFA 1025

  Fly   731 SYIKALDSTFLLGIVISLFVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLP 795
            :|:||. ..|||.::|...:....::..:|::|:.|.  .:.||....:.   |.:.|...|.:.
Zfish  1026 TYLKAA-GLFLLPLLIVSQLAKHSLMVAIDFWLAHWT--SDVIAAQSESA---ERNCTFTKDCVF 1084

  Fly   796 INATDPYIAPLLASDIQAGIRQELVLFYATILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGI 860
            .::....:..||.:                 ||  :::.|:.:.......||::..||..|.|.|
Zfish  1085 SHSWYLQVFCLLCA-----------------LG--IVLCLVTSLAVEWTGLRVAKELHCSLLRII 1130

  Fly   861 TRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCL--AFIIDVSGVVIIVAIANYWL--LI 921
            ..|.|..|.|...|.||||||.|..|:|..:|.| ::||  :.::.||.|.:|..:...:|  |:
Zfish  1131 VLAPMRLFETTPLGNILNRFSTDTNTIDQHIPVT-MECLSRSTLLCVSAVGVISYVTPVFLIALL 1194

  Fly   922 PAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQ 986
            |..:....:.  :|..| .||.:::||..:..|:.|..:||.:|||||||.:.:...:::..|:.
Zfish  1195 PLTVACYFIQ--KYFRV-ASRDLQQLEDSTEMPLLSHYSQTIEGLTTIRAFRHEQRFKKKLLEHT 1256

  Fly   987 NTNTSAWFLFLSCTRAFALWSDV------LCIVYMTAVTFSFLLLKDEFDSGDVGLAILHSTTMT 1045
            :.|..: .|||:....   |.:|      ..:|.:.||......|..:..:|.|||.:.::..::
Zfish  1257 DANNIS-SLFLTAANR---WLEVRMEYIGALVVLIAAVASITNALYRQLSAGLVGLGLTYALMVS 1317

  Fly  1046 GMCQWGMRQTAELENQMTSVERV--LEYTEQPSEALLETPEKFKPKSEWPSKGRIEFINFKLRYS 1108
            ....|.:|..|::|.|:..|:||  |.:|:..|...:.||.:.  .:.||..|.|:..|..:||.
Zfish  1318 NYLNWIVRNLADMEVQLGCVKRVSGLIHTQPESYDNIMTPAQV--PAGWPKYGEIQIQNLSVRYD 1380

  Fly  1109 PKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRLACN-EGMIRIDDVDIEHIGLHDLRS 1172
            ....||||.::..|.|.:|:||.||||:||||...::||:... ||.|.||.:||..:.|..|||
Zfish  1381 SSLKPVLKHVSAHIRPGQKVGICGRTGSGKSSFSLALFRMVDTFEGQISIDGIDISKLPLQTLRS 1445

  Fly  1173 QVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVG 1237
            :.|||.|||:|||||:|:||||..:.:||.:|:||...:|...|..|.|||:..:.:||.|||.|
Zfish  1446 KFSIILQDPILFSGTIRFNLDPERKATDEMLWEALEIAQLMPVVKALPGGLDAVVTEGGENFSQG 1510

  Fly  1238 QRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVL 1302
            ||||.|||||.:|.:.|||||||||::|..|:.::|:.:.:.||..||:|||||:||::.||.|:
Zfish  1511 QRQLFCLARAFVRKSSILIMDEATASIDMATESILQKVVMTAFADRTVVTIAHRVHTILGSDVVI 1575

  Fly  1303 VMDAGEVRELGHPYELLQR 1321
            ||..|.:.|...|..||::
Zfish  1576 VMKHGGIIEYDEPDVLLEQ 1594

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rdogNP_651678.1 CFTR_protein 12..1343 CDD:273530 417/1446 (29%)
ABC_membrane 94..360 CDD:294371 68/308 (22%)
ABCC_MRP_domain1 448..650 CDD:213217 80/233 (34%)
ABC_membrane 821..1046 CDD:294371 67/234 (29%)
ABCC_MRP_domain2 1096..1315 CDD:213211 108/219 (49%)
abcc8bXP_021323602.1 SunT 239..1600 CDD:331423 414/1438 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170586046
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.740

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