Protein Alignment rdog and abcc3

DIOPT Version :10

• Sequence 1: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_001107301.1
• Gene: abcc3 / 100135090
• XenbaseID: XB-GENE-1003737
• Length: 1531
• Species: Xenopus tropicalis
• Alignment Length: 1422
• Identity: 482/1422 - (33%)
• Similarity: 728/1422 - (51%)
• Gaps: 222/1422 - (15%)

  Fly    14 PFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWE----------- 67
            |.:.|.|.|:.:|||...:...|.:.||.|::|:...:...|..|.....:.||
 Frog   208 PESDAGFLSRLTFWWFTKMAILGYKRPLEDKDLWSLNEDDTSNVVVTNLIKEWEKEKSNLAQMQV 272

  Fly    68 -------------------------DELKRSNPSVVRMILRAYGKIFVPMGLAFSISETICKSLM 107
                                     |..|...||.::::||.:|..|: :|..|.:.:.:...:.
 Frog   273 SYSKKPEAVLNHTDEKAYESDVLIVDNKKPKEPSFLKVLLRTFGPYFL-IGSFFKLFQDLLSFVN 336

  Fly   108 PLFLGGLVGYFATNQTDISENTAYLYAMGIVICMLVPVITFHPFIFYIFQVGTKLRLALSGLIYR 172
            |..|..|:.:.  ...|......:..|:.:.:..||..:..|....|.|..|.:||.|::|:|||
 Frog   337 PQLLSILITFI--KNKDAPSWWGFCIAVLMFLTSLVQTLILHQHFQYCFVTGMRLRSAITGIIYR 399

  Fly   173 KVLQVSKSSSNDGLRGRAINILSNDLGRFDVALCFLHDTWKGPMESILIGFLMYREIGISAVIGV 237
            |.|.::.|:......|..:|::|.|..||.....||:..|..|::..|..:.:::.:|.|.:.||
 Frog   400 KSLVITNSAKRSSTVGEVVNLMSVDAQRFQDLTTFLNMLWSAPLQICLALYFLWQALGPSVLAGV 464

  Fly   238 SFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKE 302
            :.|:..||:.|:.|.|...::....:..|.|:||||||:.||:|:|:||||.|||:.:.|:|.||
 Frog   465 AVMVLLIPINAFIAMKTRAFQVEQMQYKDSRIKLMNEILNGIKVLKLYAWEPSFAQKVLEIRNKE 529

  Fly   303 VKAIRGTAYIHAALGCTSMISPLSVFL-ALCSYVYLGDP--LTAQKVYTVSSYFNMLNDSMVTFW 364
            :..::..||::|........:|..|.| ....||.:.:.  |.|:|.:...|.||:|...: ...
 Frog   530 LNILKKAAYLNALSTFAWTSAPFLVALTTFAVYVTVDEKNILDAEKAFVSLSLFNILRFPL-NML 593

  Fly   365 PMSITFIAEALVSAKRCKDFLLDGDKAEVPINLEANQQTGKNKRKISKKDKQKNVELNGSLLSNG 429
            |..|:.:|:|.||.||.::||.:.:       |:.|..|         |||    .|.|:.::
 Frog   594 PQVISNLAQASVSIKRIQNFLANDE-------LDLNAVT---------KDK----TLPGNAIT-- 636

  Fly   430 QVHHNRLRDYDPEATKKCVVLKNVSASWDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSF 494
             ||                   |.:.||..:.|   ..:::.:..:...:|.||||.||.||||.
 Frog   637 -VH-------------------NGTFSWAKNGG---AILQNINLLVPSGSLVAVVGQVGCGKSSL 678

  Fly   495 LNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMEL 559
            ::.||||:..::||..|.|.::|..|::|:...|::|||:|....||:.||||::.|.|..|:|:
 Frog   679 VSALLGEMEKEEGEVSVRGSVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVTDLEV 743

  Fly   560 LPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCI--RDFL 622
            ||.||.|.:||:|::||||||.||||||||:..||:|||||||||||.||.|||||..|  ...|
 Frog   744 LPGGDQTEIGEKGINLSGGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLL 808

  Fly   623 SNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQRS--------RQFQFLEQTQHDESGI 679
            ..|.|:||||.:.:|..|:|::::..|::...||||||.:.        |.:.|.::.:.::..|
 Frog   809 RGKTRVLVTHGISFLPQVDHIVVLVDGRVTEMGSYQELLKQNGAFSEFLRNYAFDDEVEEEDITI 873

  Fly   680 D--------THSVSSYLSRSDSEKSMEHQHNQLLR------------------------PDEHV- 711
            .        ..::|::...:|:|........:.:|                        |.|::
 Frog   874 PDEEEVLLAEETLSTHTDLADNEPVANEARKKFIRQISILSDGEPSHAMSTRRRFTEKKPSENLV 938

  Fly   712 ------EDVNQEQQT-VGSIKMHVYASYIKALDSTFLLGIVISLFV-----CARIMLTGVDYFLS 764
                  |.:.|.:.| .|.:||.|:..|:||      :|:.||:|:     |......|.:.:||
 Frog   939 AKQPPTEKLIQTETTETGRVKMTVFWQYMKA------VGLAISVFICFLYSCQNAAAIGANVWLS 997

  Fly   765 RWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVL----FYAT 825
            .|.          ...::|:|.   .|..:.:..   |.|        .||.|.|::    |...
 Frog   998 DWT----------NEPVINQTQ---QNTQMRVGV---YAA--------LGILQGLLVMTSSFSLA 1038

  Fly   826 ILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTD 890
            |.|                 :..:..||..|..........|::|...|||:|||||||..:|..
 Frog  1039 IAG-----------------IGAARKLHSALLDNKMHTPQSFYDTTPIGRIINRFSKDIYVIDEV 1086

  Fly   891 LPHTLLDCLA-FIIDVSGVVIIVAIANYW--LLIPAAIIGVILGMIRYLYVNTSRSVKRLESISR 952
            :|.|:|..|| |...:|.:::|||....:  ::||.||..:   .::..||.|||.:|||||:||
 Frog  1087 IPGTILMFLATFFTSLSTMIVIVASTPLFAVVIIPLAIAYI---FVQRFYVATSRQLKRLESVSR 1148

  Fly   953 SPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDVL------C 1011
            ||::|..::|..|.:.|||...|::.........:.|..:::..:...|    |..|.      |
 Frog  1149 SPIYSHFSETITGASIIRAYGRQNSFIVLSDNKVDENQKSYYPGIVSNR----WLGVRVEFVGNC 1209

  Fly  1012 IVYMTAVTFSFLLL-KDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQP 1075
            :|...|:   |.:| ::....|.|||::.::..:|....|.:|.|::||..:.:||||.||.|..
 Frog  1210 VVLFAAL---FAVLGREHLSPGLVGLSVSYALQVTMSLNWMVRMTSDLETNIVAVERVKEYAENE 1271

  Fly  1076 SEALLETP---EKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAG 1137
            :||    |   |..||..:|||||.:|..|:.:||......|||:||..:...||:|||||||||
 Frog  1272 TEA----PWHIEDTKPPEDWPSKGEVELSNYSVRYRAGLDLVLKNLNLKVNGGEKVGIVGRTGAG 1332

  Fly  1138 KSSIIQSIFR-LACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDE 1201
            |||:...:|| |...||:::||:|:|..|||.||||:::||||||||||||||.||||.::.||:
 Frog  1333 KSSMTLCLFRILEPAEGIVKIDNVNISEIGLQDLRSRLTIIPQDPVLFSGTLRMNLDPFNKYSDD 1397

  Fly  1202 EMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDP 1266
            |:||||....|:.:|:.....|.....:||.|.|||||||||||||:||..:|||:|||||.:|.
 Frog  1398 EIWKALELSNLKKFVAGQPSQLEYECSEGGENLSVGQRQLVCLARALLRKTRILILDEATAAIDL 1462

  Fly  1267 ETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTG 1323
            |||.|||.|||::|..||||||||||:|:||..||||:|.|.:.|...|..|:...|
 Frog  1463 ETDDLIQMTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGRIAEFDTPTNLIALKG 1519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	MRP_assoc_pro	14..1323	CDD:188098	481/1420 (34%)
abcc3	NP_001107301.1	MRP_assoc_pro	7..1530	CDD:188098	482/1422 (34%)