Protein Alignment rdog and abcc6b.2

DIOPT Version :10

• Sequence 1: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: XP_003198194.2
• Gene: abcc6b.2 / 100002917
• ZFINID: ZDB-GENE-110208-2
• Length: 1502
• Species: Danio rerio
• Alignment Length: 1409
• Identity: 465/1409 - (33%)
• Similarity: 729/1409 - (51%)
• Gaps: 200/1409 - (14%)

  Fly     7 KVVRPKN--PFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERV----TNKFAEL 65
            |.|..||  |...|:|.|:..|||...|..:|.:.||..|:|:..|:...||::    ..::|:.
Zfish   198 KPVYVKNPCPVEDASFLSKLLFWWYGRLVVKGYRSPLKAEDLWSLREEDTSEKIICDLEKEWAKQ 262

  Fly    66 WED-ELKRSN-----------PSVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGG----- 113
            |.. :.|:|:           .|.|:.:.|   |:|......|.:..|:.|...|.||.|
Zfish   263 WAKLQQKKSSLNEAQTLGFKLSSCVKQLFR---KLFKEQCTGFVLFRTLAKIFSPYFLTGTLFLV 324

  Fly   114 ---------------LVGYFATNQTDISENTAYLYAMGIVICMLVPVITFHPFIFYIFQVGTKLR 163
                           |:||.......:.:  .||:|..:.:...:..:..|.:::....||.:::
Zfish   325 IQDALMFSIPQVLSLLLGYVRDEDAPLWK--GYLFAFSLFLLSCLQSLFNHQYMYTCLTVGMRVK 387

  Fly   164 LALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDVALCFLHDTWKGPMESILIGFLMYRE 228
            .|:.||:|||.|.::.::......|..:|::|.|..:....:.:.:..|..|:|..|..|.:::.
Zfish   388 TAVMGLVYRKSLVINSAARKTCTVGEIVNLVSADTQKLVDFVMYFNALWLAPIEIALCLFFLWQH 452

  Fly   229 IGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFAR 293
            :|.|.:.|::.::...||..:.||..:..:::..:..|.|:||||||:.||:::|.|||||:|..
Zfish   453 LGPSTLAGITTVILIFPLNGFIAKMRSKLQEVQMKHKDERIKLMNEILSGIKILKFYAWEKAFRE 517

  Fly   294 VIAEVRLKEVKAIRGTAYIHAALGCTSMISPLSVFLALCS-YVYLGDP--LTAQKVYTVSSYFNM 355
            .:...|.||:.|::.:..:::....:...|.|.:..|:.. ||.:.|.  |.|||::...:..|:
Zfish   518 RVLGYREKELNALKKSQILYSVSIASFNSSTLLIAFAMFGVYVLIDDKHVLDAQKIFVSMALINI 582

  Fly   356 LNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPINLEANQQTGKNKRKISKKDKQKNVE 420
            |. :.::..|::::...:.:||.||...||   |:.|:                  |.|..:.|.
Zfish   583 LK-APLSQLPIAMSTTMQVVVSLKRLGTFL---DQDEL------------------KLDSVQRVP 625

  Fly   421 LNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWDTSDGHANCAIEDFSTDIKDQTLAAVVG 485
            .|.::.|                    ||:.|.:.||  |.....| :...:..::..:|.||||
Zfish   626 YNPNIES--------------------VVINNGTFSW--SKDSTPC-LRRINVKVQRGSLVAVVG 667

  Fly   486 PVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKV 550
            .||:||||.|:.:|||:....|...:.|.:.|..|::|:...|::|||:|..:..:..|:||::.
Zfish   668 HVGSGKSSLLSAMLGEMEKKSGHITITGSVGYVPQQAWIQNATLKDNILFGCEKKDSLYQKVLEA 732

  Fly   551 CGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFD 615
            |.|..|:|:||..|.|.:||:|::||||||.||||||||||.:|||||||||||||.|||:|||:
Zfish   733 CALLPDLEILPARDATEIGEKGLNLSGGQKQRVSLARAVYRNSDIYLLDDPLSAVDAHVGQHIFE 797

  Fly   616 RCI--RDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQRSRQFQFLE-----QTQ 673
            :.|  ...|.||.|:||||.:.:|...:.:|:|..|:|...|||.|| .||:..|.|     .::
Zfish   798 KVIGPNGSLKNKTRVLVTHGLSFLPQADLILVMADGEIKEMGSYAEL-LSRKNAFAELKAFSVSE 861

  Fly   674 HDESGI--DTHSVSSYLSRSDSEKSMEHQHNQLLRPD---------EHVED--VNQEQQTV---- 721
            ..||..  .|....|:||..|..       ..|:|.|         |.:.|  :||::..|
Zfish   862 RKESATLKGTRKSVSFLSIKDFS-------TDLIRGDLGSASIQTMEAISDPKLNQDRDEVGRLT 919

  Fly   722 -------GSIKMHVYASYIKALDSTFLLGIVISLFVCARIMLTGVDYFLSRWVIWEEQIAVNRTT 779
                   |.:|:.:|..|.:.:...|::.|:. |:...::.....:|:||.|
Zfish   920 QADKAHTGRVKLEMYVEYFRTIGLAFIIPIIF-LYAFQQVASLAYNYWLSLW------------- 970

  Fly   780 TLLNETDTTIANDTLPINATDPYIAPLLASDIQAGI------RQELVLFYATI---LGATLIVYL 835
                      |:|.: ||.|.      :.:|::.|:      .|.:.:|..|:   ||..:
Zfish   971 ----------ADDPV-INGTQ------VNTDLKLGVYGALGFAQGIAIFGTTVAISLGGII---- 1014

  Fly   836 IRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCLA 900
                        .|..||..|...:..:.|.||.:..||.:||||||:|..:|..:||.|...|.
Zfish  1015 ------------ASRQLHLDLLNNVLHSPMSFFESTPSGNLLNRFSKEIDAIDCMIPHGLKIMLG 1067

  Fly   901 FIIDVSGVVIIVAIANYW---LLIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQT 962
            ::..:..|.|||.:|..:   :::|   :.::...|:..||.||..::||||:||||:::..|:|
Zfish  1068 YVFKLLEVCIIVLMATPFAGVIILP---LTLLYAFIQSFYVATSCQLRRLESVSRSPIYTHFNET 1129

  Fly   963 FQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDVLCIVYMTAVTFSFLLLKD 1027
            .||.:.|||...|.....:.:...:.|.:::|.....:|..|:..:.|..:.:.|.....::.:.
Zfish  1130 VQGASVIRAFGEQPRFILQANCRVDLNQTSYFPRFVASRWLAVNLEFLGNLLVLAAAILSVMGRA 1194

  Fly  1028 EFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETPEKFKPK--- 1089
            ....|.||||:.||..:||:..|.:|...::||.:.|||||.||.|...||    |..|:..
Zfish  1195 TLSPGTVGLAVSHSLQVTGILSWIVRSWTDVENNIVSVERVKEYAETAKEA----PWTFEDSPLP 1255

  Fly  1090 SEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFR-LACNEG 1153
            |:||..|.|.|..:.|:|.......||:::.::..|||:||||||||||||:...||| |...:|
Zfish  1256 SDWPRSGSIGFQAYGLQYRKGLDWALKEISLSVNEREKVGIVGRTGAGKSSLALGIFRILEAAKG 1320

  Fly  1154 MIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVST 1218
            .|.||.::|..||||:|||:::|||||||||||:||.||||.|..:|||:|::|....|:::||.
Zfish  1321 KIFIDGINIAEIGLHELRSRITIIPQDPVLFSGSLRINLDPFDRYTDEEVWRSLELAHLKTFVSD 1385

  Fly  1219 LIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHC 1283
            |...||....:||.|.|:|||||:|||||:||..|||::|||||.||.:||.|||.|||::|..|
Zfish  1386 LPDKLNHECSEGGENLSLGQRQLICLARALLRKTKILVLDEATAAVDLKTDNLIQSTIRTQFEDC 1450

  Fly  1284 TVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLR 1327
            |||||||||:|:||..||:|||.|.:.|:..|..|:.:.|.:.|
Zfish  1451 TVLTIAHRLNTIMDYTRVIVMDRGNITEIDSPSNLISQHGQFYR 1494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	MRP_assoc_pro	14..1323	CDD:188098	459/1394 (33%)
abcc6b.2	XP_003198194.2	MRP_assoc_pro	5..1501	CDD:188098	465/1409 (33%)