Protein Alignment Rpn2 and RPN2

DIOPT Version :10

• Sequence 1: NP_001263057.1
• Gene: Rpn2 / 43449
• FlyBaseID: FBgn0028692
• Length: 1029
• Species: Drosophila melanogaster
• Sequence 2: NP_012190.1
• Gene: RPN2 / 854735
• SGDID: S000001337
• Length: 945
• Species: Saccharomyces cerevisiae
• Alignment Length: 1043
• Identity: 397/1043 - (38%)
• Similarity: 603/1043 - (57%)
• Gaps: 128/1043 - (12%)

  Fly     1 MSLTSAAGIISLLDEPMPDLKVFALKKLDNIVDEFWPEISESIEKIEMLHEDRSFPENKLAGMVA 65
            ||||:||.:::||.|....:|.:||:.::|:||:.|.|||..:..||.|::|.:|.:.::|.::|
Yeast     1 MSLTTAAPLLALLRENQDSVKTYALESINNVVDQLWSEISNELPDIEALYDDDTFSDREMAALIA 65

  Fly    66 SKVFYHLGSFEDALTYALGAGDLFDVNARNEYTETIIAKCIDFYIAQRVEFIENPKE---ASVVD 127
            |||:|:||.:|.|:.|||.|.|.||::.::::.|||::|.|:.|:.:..:.....::   ..::|
Yeast    66 SKVYYNLGEYESAVKYALAAKDRFDIDEKSQFVETIVSKSIEMYVQEASKQYTKDEQFYTKDIID 130

  Fly   128 ERLEGIVNRMIQRCLDDNQFRQALGIALETRRMDTFKDAIMK-------SDDVRGMLAYAYNVTM 185
            .:|..|..|||::||..::.:.|||||||..|:|..:.|:..       |::|: ::.|...:.:
Yeast   131 PKLTSIFERMIEKCLKASELKLALGIALEGYRLDIIESALKSKLDQDSTSENVK-IINYLLTLAI 194

  Fly   186 SLIQNRGFRNEVLRCLVSLYRDLGVPDYVNMCQCLIFLEDPFAVAEMLDNLTRSSVETNNLMAYQ 250
            :.:.|..||:.:||.......::...||:.:.:.::.|.|.....::...|..   |.:..::.|
Yeast   195 TTVTNSKFRSSILRKSFDFLMNMPNCDYLTLNKVVVNLNDAGLALQLFKKLKE---ENDEGLSAQ 256

  Fly   251 IAFDLYESATQEFLGNVLQHLKNTAPIPTALPSTFKPQGTTSEDGAKSEGDKSKSDEDITEETPA 315
            |||||..||:|:.|..::..|       ||       ||                      ..||
Yeast   257 IAFDLVSSASQQLLEILVTEL-------TA-------QG----------------------YDPA 285

  Fly   316 DDKVERTIDSLNEVEKLHQKNIEKLISILSGEVSIDLQLQFLIRSNHADLQVLRGTKEAV--RVS 378
                                    |::||||..:.|....||:.:.:.|:.:|..:|.::  :.|
Yeast   286 ------------------------LLNILSGLPTCDYYNTFLLNNKNIDIGLLNKSKSSLDGKFS 326

  Fly   379 ICHTATVIANAFMHSGTTSDQFLRDNLDWLARATNWAKLTATASLGVIHRGHEKDSLALMQSYLP 443
            :.|||..:||.|||:|||.:.|::.||.||.:|.||||.||||||||||:|:..:...:|..|||
Yeast   327 LFHTAVSVANGFMHAGTTDNSFIKANLPWLGKAQNWAKFTATASLGVIHKGNLLEGKKVMAPYLP 391

  Fly   444 KEAGPSSGYSEGGALYALGLIHANHGANIIDYL----LQQLKDAQNENV---RHGGCLGLGLAGM 501
            .... ||.:.:||:||.||||:|..|.:..|||    ::....:.:|:|   .||..||:|||.|
Yeast   392 GSRA-SSRFIKGGSLYGLGLIYAGFGRDTTDYLKNIIVENSGTSGDEDVDVLLHGASLGIGLAAM 455

  Fly   502 GTHRQDLYEQLKFNLYQDDAVTGEAAGIAMGMVMLGSKNAQAIEDMVSYAQETQHEKILRGLAVG 566
            |:...::||.||..||.|.|.:||||.:.||:.|||:...:||.||.:|:|||||..|.||||||
Yeast   456 GSANIEVYEALKEVLYNDSATSGEAAALGMGLCMLGTGKPEAIHDMFTYSQETQHGNITRGLAVG 520

  Fly   567 ISLTMFSRLEEADPLVTSLSSDKDPVLRRSGMYTIAMAYNGTGSNKAIRKLLHVAVSDVNDDVRR 631
            ::|..:.|.|.||.|:|.:.:..:.:||..|.:|||:||.|||:|.|:::||||||||.||||||
Yeast   521 LALINYGRQELADDLITKMLASDESLLRYGGAFTIALAYAGTGNNSAVKRLLHVAVSDSNDDVRR 585

  Fly   632 AAVTAIGFILFRSPEQCPSVVSLLAESYNPHVRYGAAMALGIACAGTGLREAIALLEPMVKFDPV 696
            |||.|:||:|.|.....|.:|.||::|:|.|||.|.|.||||||||.||:.||.:|:|:.| |||
Yeast   586 AAVIALGFVLLRDYTTVPRIVQLLSKSHNAHVRCGTAFALGIACAGKGLQSAIDVLDPLTK-DPV 649

  Fly   697 NFVRQGALIASAMILIQHTDQSCPKSTFFRQLYAEVISNKHEDVMAKYGAILAQGIIDAGGRNAT 761
            :||||.|:||.:|||||.|::..|:.....:.:..||:|||::.:||:||.:||||::|||||.|
Yeast   650 DFVRQAAMIALSMILIQQTEKLNPQVADINKNFLSVITNKHQEGLAKFGACVAQGIMNAGGRNVT 714

  Fly   762 LSLQSR-TGHTNLQAVVGMLAFTQYWYWFPLAHTLSLAFTPTCVIGL-NSDLKMPKMEYKSAAKP 824
            :.|::. ||..:.::|||::.|:|:||||||||.|||:||||.|||: .||..:||.:....||.
Yeast   715 IQLENADTGTLDTKSVVGLVMFSQFWYWFPLAHFLSLSFTPTTVIGIRGSDQAIPKFQMNCYAKE 779

  Fly   825 SLYAYPAPLEEKKSEEREKVATAVLSIAARQKRRENADKKEDEKMDVDEDSKEGAAVKKDEEAKA 889
            ..::||...||...:|.|||||||||..||.|.|....|||           :|
Yeast   780 DAFSYPRMYEEASGKEVEKVATAVLSTTARAKARAKKTKKE-----------KG----------- 822

  Fly   890 DEKMVTDEKPKKKDEKEKKKEEDKEKEAAGTSSEKDKDKEKDKKEKKEPEPTSEILQNPARVLRQ 954
                 .:|:.|||:.:||:||.:..|:....:.|.|::..|:|...|..:     :.|..|:|.|
Yeast   823 -----PNEEEKKKEHEEKEKERETNKKGIKETKENDEEFYKNKYSSKPYK-----VDNMTRILPQ 877

  Fly   955 QLKVLSVIDGQSYEPLKDVT-IGGIIVFQHTGKAEDQELVEPVAAFGPMNDEEKEPEP-PEPFEY 1017
            |.:.:|.|....:.|::... ..|::|.:      |:|..||||....:...:....| |.||:
Yeast   878 QSRYISFIKDDRFVPVRKFKGNNGVVVLR------DREPKEPVALIETVRQMKDVNAPLPTPFK- 935

  Fly  1018 IED 1020
            ::|
Yeast   936 VDD 938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rpn2	NP_001263057.1	RPN2	1..1003	CDD:227446	392/1023 (38%)
		HEAT repeat	581..602	CDD:293787	6/20 (30%)
		HEAT repeat	616..639	CDD:293787	18/22 (82%)
		HEAT repeat	651..676	CDD:293787	15/24 (63%)
RPN2	NP_012190.1	RPN2	1..945	CDD:227446	397/1043 (38%)
		HEAT repeat	533..557	CDD:293787	8/23 (35%)
		HEAT repeat	567..595	CDD:293787	21/27 (78%)
		HEAT repeat	601..631	CDD:293787	17/29 (59%)
		HEAT repeat	636..662	CDD:293787	15/26 (58%)
		HEAT repeat	675..706	CDD:293787	12/30 (40%)