DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rpn2 and AT1G04810

DIOPT Version :9

Sequence 1:	NP_001263057.1	Gene:	Rpn2 / 43449	FlyBaseID:	FBgn0028692	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	NP_171973.1	Gene:	AT1G04810 / 839409	AraportID:	AT1G04810	Length:	1001	Species:	Arabidopsis thaliana

Alignment Length:	1041	Identity:	478/1041 - (45%)
Similarity:	679/1041 - (65%)	Gaps:	74/1041 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LTSAAGIISLLDEPMPDLKVFALKKLDNIVDEFWPEISESIEKIEMLHEDRSFPEN--KLAGMVA 65
            ::||.|::::|:||.|.||:.||..|..:||:||||||.|:..||.|:||..|.::  :||.::|
plant     6 VSSAGGLLAMLNEPHPSLKLHALSYLIRLVDQFWPEISTSVPIIESLYEDEEFDQHQRQLAALLA 70

  Fly    66 SKVFYHLGSFEDALTYALGAGDLFDVNARNEYTETIIAKCIDFYIAQRVEFIENPKEASVVDERL 130
            |||||:||...|:|:||||||.||||:..::|..|:::|.||.|...|.:.:|: .|...:|.||
plant    71 SKVFYYLGELNDSLSYALGAGSLFDVSEDSDYIHTLLSKAIDEYAILRSKAVES-SEVVEIDPRL 134

  Fly   131 EGIVNRMIQRCLDDNQFRQALGIALETRRMDTFKDAIMKSDDVRGMLAYAYNVTMSLIQNRGFRN 195
            ..||.||:.:|:.|.:::||:|||:|.||:|..::||:||::|:|.|:|..||:.|.:..|.:|:
plant   135 VAIVERMLDKCITDGKYQQAMGIAIECRRLDKLEEAIIKSENVQGTLSYCINVSHSFVNQREYRH 199

  Fly   196 EVLRCLVSLYRDLGVPDYVNMCQCLIFLEDPFAVAEMLDNLTRSSVETNNLMAYQIAFDLYESAT 260
            ||||.||::|:.|..|||:::||||:||::|..||.:|:.|.||..:.:.|:|:||:|||.::..
plant   200 EVLRLLVNVYQKLASPDYLSICQCLMFLDEPQGVASILEKLLRSENKDDALLAFQISFDLVQNEH 264

  Fly   261 QEFLGNVLQHLKNTAPIPTALPSTFKPQGTTSEDGAKSEGDKSKSDEDITEETPADDKVERTIDS 325
            |.||.:|...|    |.|...|    .:...:.:.:.::.:.:..|..:.:|||:...|..|
plant   265 QAFLMSVRDRL----PAPKTRP----VEAIQAVETSTAQNENTAGDVQMADETPSQTIVHET--- 318

  Fly   326 LNEVEKLHQKNIEKLISILSGEVSIDLQLQFLIRSNHADLQVLRGTKEAV--RVSICHTATVIAN 388
             :.|:.::.:.:.|...|||||.||.|.||||...|.:||.:|:..|::|  |.|:||:||:.||
plant   319 -DPVDAVYAERLTKAKGILSGETSIQLTLQFLYSHNKSDLLILKTIKQSVEMRNSVCHSATIYAN 382

  Fly   389 AFMHSGTTSDQFLRDNLDWLARATNWAKLTATASLGVIHRGHEKDSLALMQSYLPK--EAGPSSG 451
            |.||:|||.|.|||:|||||:|||||||.:|||.||||||||.:...:||..|||:  ..|..|.
plant   383 AIMHAGTTVDTFLRENLDWLSRATNWAKFSATAGLGVIHRGHLQQGRSLMAPYLPQGGAGGGGSP 447

  Fly   452 YSEGGALYALGLIHANHGANIIDYLLQQLKDAQNENVRHGGCLGLGLAGMGTHRQDLYEQLKFNL 516
            ||||||||||||||||||..|..:|...|:....|.::||.|||||||.:||..:|:|:.:|..|
plant   448 YSEGGALYALGLIHANHGEGIKQFLRDSLRSTSVEVIQHGACLGLGLAALGTADEDIYDDIKSVL 512

  Fly   517 YQDDAVTGEAAGIAMGMVMLGSKNAQAIEDMVSYAQETQHEKILRGLAVGISLTMFSRLEEADPL 581
            |.|.||.||||||:||::::|:...:|.| |::||.|||||||:||||:||:||::.|.|.||.|
plant   513 YTDSAVAGEAAGISMGLLLVGTATDKASE-MLAYAHETQHEKIIRGLALGIALTVYGREEGADTL 576

  Fly   582 VTSLSSDKDPVLRRSGMYTIAMAYNGTGSNKAIRKLLHVAVSDVNDDVRRAAVTAIGFILFRSPE 646
            :..::.|:||::|..|||.:|:||:||.:|||||:|||.|||||:|||||.||.|:||:|:..||
plant   577 IEQMTRDQDPIIRYGGMYALALAYSGTANNKAIRQLLHFAVSDVSDDVRRTAVLALGFVLYSDPE 641

  Fly   647 QCPSVVSLLAESYNPHVRYGAAMALGIACAGTGLREAIALLEPMVKFDPVNFVRQGALIASAMIL 711
            |.|.:||||:||||||||||||:|:||:||||||.|||:||||:.. |.|:|||||||||.||::
plant   642 QTPRIVSLLSESYNPHVRYGAALAVGISCAGTGLSEAISLLEPLTS-DVVDFVRQGALIAMAMVM 705

  Fly   712 IQHTDQSCPKSTFFRQLYAEVISNKHEDVMAKYGAILAQGIIDAGGRNATLSLQSRTGHTNLQAV 776
            :|.::.|..:...||:...::|.:||||.|:|.|||||.||:||||||.|:.|.|:|.|..:.||
plant   706 VQISEASDSRVGAFRRQLEKIILDKHEDTMSKMGAILASGILDAGGRNVTIRLLSKTKHDKVTAV 770

  Fly   777 VGMLAFTQYWYWFPLAHTLSLAFTPTCVIGLNSDLKMPKMEYKSAAKPSLYAYPAPLEEKKSEER 841
            :|:..|:|:|||:||.:.:||||:||..||||.|||:||.|:.|.|||||:.||.|.....:...
plant   771 IGLTVFSQFWYWYPLIYFISLAFSPTAFIGLNYDLKVPKFEFMSHAKPSLFEYPKPTTVATANTA 835

  Fly   842 EKVATAVLSIAARQKRRENADKKEDEKMDVDEDSKEGAAVKKDEEAKADEKMVTDEKPKKKDEKE 906
            .|:.|||||.:|:.|                      |..||:.|.||..:...:|..|.....:
plant   836 AKLPTAVLSTSAKAK----------------------AKAKKEAEQKAKAENSGNEAGKANAASD 878

  Fly   907 KKKEEDKEKEAAGTSSEKDKDKEKDKKEKKEPEPTSEILQNPARVLRQQLKVLSVIDGQSYEPLK 971
            :|:.|..:.::..|:.||          |.|||.|.|||.|||||:..|.|.:.:::...|.|:|
plant   879 EKEAESMQVDSTATTVEK----------KVEPEATFEILVNPARVVPSQEKYIKLMEDSRYVPMK 933

  Fly   972 DVTIGGIIVFQHTGKAEDQELV---EPVAAFGPMNDEE-----------------KEPEPPEPFE 1016
             :...|.::.:.....|.:.|.   .|.:...|....|                 .||:||:.||
plant   934 -LAPSGFVLLRDLRPHEPEVLSLTDAPTSTASPAVGAEAAGQAQQAATTSAMAIDDEPQPPQAFE 997

  Fly  1017 Y 1017
            |
plant   998 Y 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn2	NP_001263057.1	RPN2	1..1003	CDD:227446	470/1008 (47%)
		PC_rep	456..489	CDD:280095	18/32 (56%)
		PC_rep	526..559	CDD:280095	17/32 (53%)
		HEAT repeat	581..602	CDD:293787	8/20 (40%)
		HEAT repeat	616..639	CDD:293787	16/22 (73%)
		HEAT repeat	651..676	CDD:293787	19/24 (79%)
		PC_rep	666..701	CDD:280095	23/34 (68%)
AT1G04810	NP_171973.1	RPN2	6..953	CDD:227446	467/994 (47%)
		HEAT repeat	574..598	CDD:293787	9/23 (39%)
		HEAT repeat	608..637	CDD:293787	21/28 (75%)
		HEAT repeat	644..672	CDD:293787	21/27 (78%)
		HEAT repeat	677..703	CDD:293787	18/26 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	393	1.000	Domainoid score	I143
eggNOG	1	0.900	-	-		E1_COG5116
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2100
Inparanoid	1	1.050	883	1.000	Inparanoid score	I57
OMA	1	1.010	-	-		QHG53911
OrthoDB	1	1.010	-	-		D235012at2759
OrthoFinder	1	1.000	-	-		FOG0004235
OrthoInspector	1	1.000	-	-		otm2397
orthoMCL	1	0.900	-	-		OOG6_101410
Panther	1	1.100	-	-	O	PTHR10943
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2978
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840