Protein Alignment Rpn2 and Psmd1

DIOPT Version :10

• Sequence 1: NP_001263057.1
• Gene: Rpn2 / 43449
• FlyBaseID: FBgn0028692
• Length: 1029
• Species: Drosophila melanogaster
• Sequence 2: NP_114184.2
• Gene: Psmd1 / 83806
• RGDID: 621669
• Length: 953
• Species: Rattus norvegicus
• Alignment Length: 1023
• Identity: 641/1023 - (62%)
• Similarity: 790/1023 - (77%)
• Gaps: 76/1023 - (7%)

  Fly     3 LTSAAGIISLLDEPMPDLKVFALKKLDNIVDEFWPEISESIEKIEMLHEDRSFPENKLAGMVASK 67
            :||||||||||||..|.||.|||.||:.:|::||.|||||::|||:|:||..|...:.|.:||||
  Rat     2 ITSAAGIISLLDEEEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASK 66

  Fly    68 VFYHLGSFEDALTYALGAGDLFDVNARNEYTETIIAKCIDFYIAQRVEFIENPK-EASVVDERLE 131
            ||||||:||::|.|||||||||:||..:||.|||||||||.|..|.||..:.|: |...:|:|||
  Rat    67 VFYHLGAFEESLNYALGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVENADLPEGEKKPIDQRLE 131

  Fly   132 GIVNRMIQRCLDDNQFRQALGIALETRRMDTFKDAIMKSDDVRGMLAYAYNVTMSLIQNRGFRNE 196
            ||||:|.||||||::::||:||||||||:|.|:..|::|:||.|||||:..:.|||:||:.|||:
  Rat   132 GIVNKMFQRCLDDHKYKQAIGIALETRRLDVFEKTILESNDVPGMLAYSLKLCMSLMQNKQFRNK 196

  Fly   197 VLRCLVSLYRDLGVPDYVNMCQCLIFLEDPFAVAEMLDNLTRSSVETNNLMAYQIAFDLYESATQ 261
            |||.||.:|.:|..||::|:|||||||:||.||:::|:.|.:   |.|.||||||.|||||||:|
  Rat   197 VLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVK---EDNLLMAYQICFDLYESASQ 258

  Fly   262 EFLGNVLQHLKNT-APIPTALPSTFKPQGTTSEDGAKSEGDKSKSDEDITEETPADDKVERTIDS 325
            :||.:|:|:|:.. .||.:...||  ..||.       .|.:..||...|||..|.....:|.|:
  Rat   259 QFLSSVIQNLRTVGTPIASVPGST--NTGTV-------PGPEKDSDSMETEEKTAGAVAGKTPDA 314

  Fly   326 LNEVEKLHQKNIEKLISILSGEVSIDLQLQFLIRSNHADLQVLRGTKEAVRVSICHTATVIANAF 390
            ..|    .:....|:|.|||||::|:|.||||||:|:.||.:|:.||:|||.|:|||||||||:|
  Rat   315 SPE----PKDQTLKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAVRNSVCHTATVIANSF 375

  Fly   391 MHSGTTSDQFLRDNLDWLARATNWAKLTATASLGVIHRGHEKDSLALMQSYLPKEAGPSSGYSEG 455
            ||.||||||||||||:||||||||||.||||||||||:||||::|.||.:||||:..|.|.|.||
  Rat   376 MHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEALQLMATYLPKDTSPGSAYQEG 440

  Fly   456 GALYALGLIHANHGANIIDYLLQQLKDAQNENVRHGGCLGLGLAGMGTHRQDLYEQLKFNLYQDD 520
            |.||||||||||||.:||||||.|||:|.|:.|||||.||||||.|||.|||:|:.||.||||||
  Rat   441 GGLYALGLIHANHGGDIIDYLLNQLKNASNDIVRHGGSLGLGLAAMGTARQDVYDLLKTNLYQDD 505

  Fly   521 AVTGEAAGIAMGMVMLGSKNAQAIEDMVSYAQETQHEKILRGLAVGISLTMFSRLEEADPLVTSL 585
            ||||||||:|:|:|||||||||||||||.||||||||||||||||||:|.|:.|:||||.|:.||
  Rat   506 AVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVMYGRMEEADALIESL 570

  Fly   586 SSDKDPVLRRSGMYTIAMAYNGTGSNKAIRKLLHVAVSDVNDDVRRAAVTAIGFILFRSPEQCPS 650
            ..||||:||||||||:||||.|:|:|||||:||||||||||||||||||.::||||||:||||||
  Rat   571 CRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPS 635

  Fly   651 VVSLLAESYNPHVRYGAAMALGIACAGTGLREAIALLEPMVKFDPVNFVRQGALIASAMILIQHT 715
            |||||:||||||||||||||||:.|||||.:|||.|||||.. ||||:||||||||||:|:||.|
  Rat   636 VVSLLSESYNPHVRYGAAMALGVCCAGTGNKEAINLLEPMTN-DPVNYVRQGALIASALIMIQQT 699

  Fly   716 DQSCPKSTFFRQLYAEVISNKHEDVMAKYGAILAQGIIDAGGRNATLSLQSRTGHTNLQAVVGML 780
            :.:|||...|||||::||::||:|||||:||||||||:||||.|.|:|||||||||::.:|||:|
  Rat   700 EITCPKVNQFRQLYSKVINDKHDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVL 764

  Fly   781 AFTQYWYWFPLAHTLSLAFTPTCVIGLNSDLKMPKMEYKSAAKPSLYAYPAPLEEKKSEEREKVA 845
            .|||:|:||||:|.||||:|||||||||.||||||::|||..|||.:|||||||..|.:|:|||:
  Rat   765 VFTQFWFWFPLSHFLSLAYTPTCVIGLNKDLKMPKVQYKSNCKPSTFAYPAPLEVPKEKEKEKVS 829

  Fly   846 TAVLSIAARQKRRE-NADKKEDEKMDVDEDSKEGAAVKKDEEAKADEKMVTDEKPKKKDEKEKKK 909
            ||||||.|:.|::| ..:|||:|||:|||                         .:||:||||
  Rat   830 TAVLSITAKAKKKEKEKEKKEEEKMEVDE-------------------------AEKKEEKEK-- 867

  Fly   910 EEDKEKEAAGTSSEKDKDKEKDKKEKKEPEPTSEILQNPARVLRQQLKVLSVIDGQSYEPLKDVT 974
                                     ||||||..::|.|||||:..||||||:.:...|:|.|.::
  Rat   868 -------------------------KKEPEPNFQLLDNPARVMPAQLKVLSMTETCRYQPFKPLS 907

  Fly   975 IGGIIVFQHTGKAED-QELVEPVAAFGP-MNDEEKEPEPPEPFEYIED 1020
            |||||:.:.|  :|| :||||||||.|| :.:||:|||||||||||:|
  Rat   908 IGGIIILKDT--SEDIEELVEPVAAHGPKIEEEEQEPEPPEPFEYIDD 953

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rpn2	NP_001263057.1	RPN2	1..1003	CDD:227446	627/1004 (62%)
		HEAT repeat	581..602	CDD:293787	15/20 (75%)
		HEAT repeat	616..639	CDD:293787	18/22 (82%)
		HEAT repeat	651..676	CDD:293787	21/24 (88%)
Psmd1	NP_114184.2	RPN2	2..934	CDD:227446	626/1002 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	277..319		14/54 (26%)
		PC 1	403..436		22/32 (69%)
		PC 2	441..474		24/32 (75%)
		PC 3	476..510		26/33 (79%)
		PC 4	511..545		29/33 (88%)
		PC 5	547..580		21/32 (66%)
		HEAT repeat	565..590	CDD:293787	17/24 (71%)
		PC 6	581..616		29/34 (85%)
		HEAT repeat	601..624	CDD:293787	18/22 (82%)
		PC 7	617..649		26/31 (84%)
		HEAT repeat	636..661	CDD:293787	21/24 (88%)
		PC 8	651..685		25/34 (74%)
		HEAT repeat	667..697	CDD:293787	23/30 (77%)
		PC 9	686..726		25/39 (64%)
		PC 10	729..761		23/31 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	839..881		24/93 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	930..953		16/22 (73%)