DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rpn2 and AT2G32730

DIOPT Version :9

Sequence 1:	NP_001263057.1	Gene:	Rpn2 / 43449	FlyBaseID:	FBgn0028692	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	NP_180832.1	Gene:	AT2G32730 / 817833	AraportID:	AT2G32730	Length:	1004	Species:	Arabidopsis thaliana

Alignment Length:	1039	Identity:	487/1039 - (46%)
Similarity:	676/1039 - (65%)	Gaps:	66/1039 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LTSAAGIISLLDEPMPDLKVFALKKLDNIVDEFWPEISESIEKIEMLHEDRSFP--ENKLAGMVA 65
            ::||.|::::|:||.|.||:.||..|:|:||:||||||.|:..||.|:||..|.  :.:||.::.
plant     6 VSSAGGLLAMLNEPHPVLKLHALSNLNNLVDQFWPEISTSVPIIESLYEDEEFDLHQRQLAALLV 70

  Fly    66 SKVFYHLGSFEDALTYALGAGDLFDVNARNEYTETIIAKCIDFYIAQRVEFIENPKEASVVDERL 130
            |||||:||...|:|:||||||.||||:..::|..|::||.||.|.:.|.:.:|: .|...:|.||
plant    71 SKVFYYLGELNDSLSYALGAGPLFDVSEDSDYVHTLLAKAIDEYASLRSKAVES-NEMVDIDPRL 134

  Fly   131 EGIVNRMIQRCLDDNQFRQALGIALETRRMDTFKDAIMKSDDVRGMLAYAYNVTMSLIQNRGFRN 195
            |.||.||:.:|:.|.:::||:|||:|.||:|..::||:|||:|:|.|:|..||:.|.:..|.:|:
plant   135 EAIVERMLGKCISDGKYQQAMGIAIECRRLDKLEEAIIKSDNVQGTLSYCINVSHSFVNRREYRH 199

  Fly   196 EVLRCLVSLYRDLGVPDYVNMCQCLIFLEDPFAVAEMLDNLTRSSVETNNLMAYQIAFDLYESAT 260
            |||..||.:|:.|..|||:::||||:||::|..||.:|:.|.||..:.:.|:|.||||||.|:..
plant   200 EVLSLLVKVYQKLPSPDYLSICQCLMFLDEPQGVASILEKLLRSENKDDALLALQIAFDLVENEH 264

  Fly   261 QEFLGNVLQHLKNTAPIPTALPSTFKPQGTTSEDGAKSEGDKSKSDEDITEETPADDKVERTIDS 325
            |.||.:|...|        ..|.|...:.|.:.:...:..:....|..:.:||||...|..|
plant   265 QAFLLSVRDRL--------PAPKTRAVEATQAVETTIAPNENPSGDVQMADETPAQTIVHET--- 318

  Fly   326 LNEVEKLHQKNIEKLISILSGEVSIDLQLQFLIRSNHADLQVLRGTKEAV--RVSICHTATVIAN 388
             :.|:..:.:.:.|:..|||||.||.|.||||...|.:||.:|:..|::|  |.|:||:||:.||
plant   319 -DPVDATYAERLTKIKGILSGETSIQLTLQFLYSHNKSDLLILKTIKQSVEMRNSVCHSATIYAN 382

  Fly   389 AFMHSGTTSDQFLRDNLDWLARATNWAKLTATASLGVIHRGHEKDSLALMQSYLPK--EAGPSSG 451
            |.||:|||.|.|||:|||||:|||||||.:|||.||||||||.:...:||..|||:  ..|..|.
plant   383 AIMHAGTTVDTFLRENLDWLSRATNWAKFSATAGLGVIHRGHLQQGRSLMAPYLPQGGAGGGGSP 447

  Fly   452 YSEGGALYALGLIHANHGANIIDYLLQQLKDAQNENVRHGGCLGLGLAGMGTHRQDLYEQLKFNL 516
            ||||||||||||||||||..|..:|...|:....|.::||.||||||:.:||..:::|:.:|..|
plant   448 YSEGGALYALGLIHANHGEGIKQFLRDSLRSTNVEVIQHGACLGLGLSALGTADEEIYDDVKSVL 512

  Fly   517 YQDDAVTGEAAGIAMGMVMLGSKNAQAIEDMVSYAQETQHEKILRGLAVGISLTMFSRLEEADPL 581
            |.|.||.||||||:||::::|:...:|.| |::||.|||||||:||||:||:||::.|.|.||.|
plant   513 YTDSAVAGEAAGISMGLLLVGTATEKASE-MLAYAHETQHEKIIRGLALGIALTVYGREEGADTL 576

  Fly   582 VTSLSSDKDPVLRRSGMYTIAMAYNGTGSNKAIRKLLHVAVSDVNDDVRRAAVTAIGFILFRSPE 646
            :..::.|:||::|..|||.:|:||:||.:|||||:|||.|||||:|||||.||.|:||:|:..||
plant   577 IEQMTRDQDPIIRYGGMYALALAYSGTANNKAIRQLLHFAVSDVSDDVRRTAVLALGFVLYSDPE 641

  Fly   647 QCPSVVSLLAESYNPHVRYGAAMALGIACAGTGLREAIALLEPMVKFDPVNFVRQGALIASAMIL 711
            |.|.:||||:||||||||||||:|:||:||||||.|||:||||:.. |.|:|||||||||.||::
plant   642 QTPRIVSLLSESYNPHVRYGAALAVGISCAGTGLSEAISLLEPLTS-DVVDFVRQGALIAMAMVM 705

  Fly   712 IQHTDQSCPKSTFFRQLYAEVISNKHEDVMAKYGAILAQGIIDAGGRNATLSLQSRTGHTNLQAV 776
            :|.::.|..:...||:...::|.:||||.|:|.|||||.||:||||||.|:.|.|:|.|..:.||
plant   706 VQISEASDSRVGVFRRQLEKIILDKHEDTMSKMGAILASGILDAGGRNVTIRLLSKTKHDKVTAV 770

  Fly   777 VGMLAFTQYWYWFPLAHTLSLAFTPTCVIGLNSDLKMPKMEYKSAAKPSLYAYPAPLEEKKSEER 841
            :|:..|:|:|||:||.:.:||||:||..||||.|||:||.|:.|.|||||:.||.|.....:...
plant   771 IGLAVFSQFWYWYPLIYFISLAFSPTAFIGLNYDLKVPKFEFMSHAKPSLFEYPKPTTVPTANTA 835

  Fly   842 EKVATAVLSIAARQKRRENADKKEDEKMDVDEDSKEGAAVKKDEEAKA-DEKMVTDEKPKKKDEK 905
            .|:.|||||.:.:.|.|                      .||:.|.|| .||....|||..:...
plant   836 VKLPTAVLSTSVKAKAR----------------------AKKEAEQKAIAEKTSGPEKPVNESGS 878

  Fly   906 EKKKEEDKEKEAAGTSSEKDKDKEKDKKEKKEPEPTSEILQNPARVLRQQLKVLSVIDGQSYEPL 970
            .|.| ...|||  |.|.:.|.....:|| ..||||..|||.|||||:..|.|.:.::|...|.|:
plant   879 GKGK-ASTEKE--GDSMQVDSPAAVEKK-APEPEPAFEILVNPARVVPAQEKYIKLLDDSRYVPV 939

  Fly   971 KDVTIGGIIVFQHTGKAEDQELV---EPVAAFGPMNDE--------------EKEPEPPEPFEY 1017
            | :...|.::.:...:.|.:.|.   .|.:...|....              :.||:||:.|||
plant   940 K-LAPSGFVLLKDLREHEPEVLSLTDAPTSTASPATGTAAAAQGTPASAMAVDDEPQPPQAFEY 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn2	NP_001263057.1	RPN2	1..1003	CDD:227446	480/1009 (48%)
		PC_rep	456..489	CDD:280095	18/32 (56%)
		PC_rep	526..559	CDD:280095	17/32 (53%)
		HEAT repeat	581..602	CDD:293787	8/20 (40%)
		HEAT repeat	616..639	CDD:293787	16/22 (73%)
		HEAT repeat	651..676	CDD:293787	19/24 (79%)
		PC_rep	666..701	CDD:280095	23/34 (68%)
AT2G32730	NP_180832.1	RPN2	6..1004	CDD:227446	487/1039 (47%)
		HEAT repeat	574..598	CDD:293787	9/23 (39%)
		HEAT repeat	608..637	CDD:293787	21/28 (75%)
		HEAT repeat	644..672	CDD:293787	21/27 (78%)
		HEAT repeat	677..703	CDD:293787	18/26 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	393	1.000	Domainoid score	I143
eggNOG	1	0.900	-	-		E1_COG5116
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2100
Inparanoid	1	1.050	883	1.000	Inparanoid score	I57
OMA	1	1.010	-	-		QHG53911
OrthoDB	1	1.010	-	-		D235012at2759
OrthoFinder	1	1.000	-	-		FOG0004235
OrthoInspector	1	1.000	-	-		otm2397
orthoMCL	1	0.900	-	-		OOG6_101410
Panther	1	1.100	-	-	LDO	PTHR10943
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2978
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840