Protein Alignment Rpn2 and PSMD2

DIOPT Version :10

• Sequence 1: NP_001263057.1
• Gene: Rpn2 / 43449
• FlyBaseID: FBgn0028692
• Length: 1029
• Species: Drosophila melanogaster
• Sequence 2: NP_002799.3
• Gene: PSMD2 / 5708
• HGNCID: 9559
• Length: 908
• Species: Homo sapiens
• Alignment Length: 779
• Identity: 163/779 - (20%)
• Similarity: 289/779 - (37%)
• Gaps: 193/779 - (24%)

  Fly    45 KIEMLHEDRSFPENK-LAGMVASKVFYHLGSFEDALTYALGAGDLFDVNARNEYTETI---IAKC 105
            |::.::|:.:..||| .|..:.|.:...:....:.|.|.|........:..:||...:   :||
Human   105 KLKEIYENMAPGENKRFAADIISVLAMTMSGERECLKYRLVGSQEELASWGHEYVRHLAGEVAK- 168

  Fly   106 IDFYIAQRVEFIENPKEASVVDERLEGIVNRMIQRCLDDNQFRQALGIALETRRMDTFKDAIMKS 170
                     |:.|......|..|.|..:|..::...:..|...:|..:.:|..::|..:..|.::
Human   169 ---------EWQELDDAEKVQREPLLTLVKEIVPYNMAHNAEHEACDLLMEIEQVDMLEKDIDEN 224

  Fly   171 DDVRGMLAYAYNVTMSLIQNRGF-----RNEVLRCLVSLYRDLG-VPDYVNMCQCLIFLEDPFAV 229
                   ||| .|.:.|.....:     .:.:|||.:.::|... .|:.:.:.   :.|.|
Human   225 -------AYA-KVCLYLTSCVNYVPEPENSALLRCALGVFRKFSRFPEALRLA---LMLND---- 274

  Fly   230 AEMLDNLTRSSVETNNLMAYQIAFDLYESATQEFLGNVLQHLKNTAPIPTALPSTFKPQGTTSED 294
            .|:::::..|..:.  ::..|:||         .||.
Human   275 MELVEDIFTSCKDV--VVQKQMAF---------MLGR---------------------------- 300

  Fly   295 GAKSEGDKSKSDEDITEETPADDKVERTIDSLNEVEKLHQKN-----IEKLISILSGEVSIDLQL 354
                .|...:..||:.|           .:.|.|:....|.|     :.:.:.|:..:|..|
Human   301 ----HGVFLELSEDVEE-----------YEDLTEIMSNVQLNSNFLALARELDIMEPKVPDD--- 347

  Fly   355 QFLIRSNHADLQVLRGTKEAVRVSICHTATVIANAFMHSGTTSDQFLRDNLD-WLARATNWAKLT 418
               |...|.:.....|:...|..:..:.|:...|.|:::....|:.|.|:.: ||.:..:...|:
Human   348 ---IYKTHLENNRFGGSGSQVDSARMNLASSFVNGFVNAAFGQDKLLTDDGNKWLYKNKDHGMLS 409

  Fly   419 ATASLGVIHRGHEKDSLALMQSYLPKEAGPSSGYSEGGALYALGLIHANHGA-NIIDYLLQQLKD 482
            |.||||:|........|..:..||..    |..|.:.|||.|.|::  |.|. |..|..|..|.|
Human   410 AAASLGMILLWDVDGGLTQIDKYLYS----SEDYIKSGALLACGIV--NSGVRNECDPALALLSD 468

  Fly   483 --AQNEN-VRHGGCLGLGLAGMGTHRQDLYEQLKFNLYQDDAVTGEAAGI---AMGMVMLGSKNA 541
              ..|.| :|.|...|||||..|::|:|:. .|...:..|...:.|.||:   |.||:.:||.|.
Human   469 YVLHNSNTMRLGSIFGLGLAYAGSNREDVL-TLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNG 532

  Fly   542 QAIEDMVSYAQETQHEK--------ILRGLAVGISLTMFSRLEEADPLVTSLSSDKDPVLRRSGM 598
                |:.|...:|..||        ..|.|.:|:.|....:.|..:.::.:|....:|....:..
Human   533 ----DVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFANT 593

  Fly   599 YTIAMAYNGTGSNKAIRKLLHVAVSDVND---------------DVRRA--------AVTAIGFI 640
            .....||.|:|:...:::|||:.....:.               |.:.|        .|..:|..
Human   594 LVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIA 658

  Fly   641 LFRSPEQCPSVVSLLAESYNPHVRYGAAMALGIACAGTGLREAIALLEPMVKFDPVNFVRQGALI 705
            |....|:..:.::|  .::...:|||                     ||.        :|:...:
Human   659 LIAMGEEIGAEMAL--RTFGHLLRYG---------------------EPT--------LRRAVPL 692

  Fly   706 ASAMILIQHTDQSCPKSTFFRQLYAEVISN-KHE-DVMAKYGAILAQGIIDAGGRNATLSLQSR 767
            |.|:|.:     |.|:....     :.:|. .|: |....|.:|.|.|::.:|..||.|:...|
Human   693 ALALISV-----SNPRLNIL-----DTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLR 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rpn2	NP_001263057.1	RPN2	1..1003	CDD:227446	163/779 (21%)
		HEAT repeat	581..602	CDD:293787	2/20 (10%)
		HEAT repeat	616..639	CDD:293787	6/45 (13%)
		HEAT repeat	651..676	CDD:293787	4/24 (17%)
PSMD2	NP_002799.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52
		RPN1	26..906	CDD:227441	163/779 (21%)
		PC 1	409..442		11/36 (31%)
		PC 2	443..479		14/37 (38%)
		PC 3	480..514		11/34 (32%)
		PC 4	517..551		11/37 (30%)
		PC 5	560..589		5/28 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..645		2/21 (10%)
		PC 6	692..723		8/40 (20%)
		Required for interaction with UBLCP1. /evidence=ECO:0000269|PubMed:28539385	708..903		12/39 (31%)