DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rpn2 and PSMD1

DIOPT Version :9

Sequence 1:	NP_001263057.1	Gene:	Rpn2 / 43449	FlyBaseID:	FBgn0028692	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	NP_002798.2	Gene:	PSMD1 / 5707	HGNCID:	9554	Length:	953	Species:	Homo sapiens

Alignment Length:	1029	Identity:	636/1029 - (61%)
Similarity:	795/1029 - (77%)	Gaps:	88/1029 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LTSAAGIISLLDEPMPDLKVFALKKLDNIVDEFWPEISESIEKIEMLHEDRSFPENKLAGMVASK 67
            :||||||||||||..|.||.|||.||:.:|::||.|||||::|||:|:||..|...:.|.:||||
Human     2 ITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASK 66

  Fly    68 VFYHLGSFEDALTYALGAGDLFDVNARNEYTETIIAKCIDFYIAQRVEFIENPK-EASVVDERLE 131
            ||||||:||::|.|||||||||:||..:||.|||||||||.|..|.||..:.|: |...:|:|||
Human    67 VFYHLGAFEESLNYALGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVENADLPEGEKKPIDQRLE 131

  Fly   132 GIVNRMIQRCLDDNQFRQALGIALETRRMDTFKDAIMKSDDVRGMLAYAYNVTMSLIQNRGFRNE 196
            ||||:|.||||||::::||:||||||||:|.|:..|::|:||.|||||:..:.|||:||:.|||:
Human   132 GIVNKMFQRCLDDHKYKQAIGIALETRRLDVFEKTILESNDVPGMLAYSLKLCMSLMQNKQFRNK 196

  Fly   197 VLRCLVSLYRDLGVPDYVNMCQCLIFLEDPFAVAEMLDNLTRSSVETNNLMAYQIAFDLYESATQ 261
            |||.||.:|.:|..||::|:|||||||:||.||:::|:.|.:   |.|.||||||.|||||||:|
Human   197 VLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVK---EDNLLMAYQICFDLYESASQ 258

  Fly   262 EFLGNVLQHLKNT-APIPTALPSTFKPQGTTSEDGAKSEGDKSKSDEDITE----ETP--ADDKV 319
            :||.:|:|:|:.. .||.:...||    .|.:..|::.:.|..:::|..:.    :||  :.:..
Human   259 QFLSSVIQNLRTVGTPIASVPGST----NTGTVPGSEKDSDSMETEEKTSSAFVGKTPEASPEPK 319

  Fly   320 ERTIDSLNEVEKLHQKNIEKLISILSGEVSIDLQLQFLIRSNHADLQVLRGTKEAVRVSICHTAT 384
            ::|:               |:|.|||||::|:|.||||||:|:.||.:|:.||:|||.|:|||||
Human   320 DQTL---------------KMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAVRNSVCHTAT 369

  Fly   385 VIANAFMHSGTTSDQFLRDNLDWLARATNWAKLTATASLGVIHRGHEKDSLALMQSYLPKEAGPS 449
            ||||:|||.||||||||||||:||||||||||.||||||||||:||||::|.||.:||||:..|.
Human   370 VIANSFMHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEALQLMATYLPKDTSPG 434

  Fly   450 SGYSEGGALYALGLIHANHGANIIDYLLQQLKDAQNENVRHGGCLGLGLAGMGTHRQDLYEQLKF 514
            |.|.|||.||||||||||||.:||||||.|||:|.|:.|||||.||||||.|||.|||:|:.||.
Human   435 SAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASNDIVRHGGSLGLGLAAMGTARQDVYDLLKT 499

  Fly   515 NLYQDDAVTGEAAGIAMGMVMLGSKNAQAIEDMVSYAQETQHEKILRGLAVGISLTMFSRLEEAD 579
            ||||||||||||||:|:|:|||||||||||||||.||||||||||||||||||:|.|:.|:||||
Human   500 NLYQDDAVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVMYGRMEEAD 564

  Fly   580 PLVTSLSSDKDPVLRRSGMYTIAMAYNGTGSNKAIRKLLHVAVSDVNDDVRRAAVTAIGFILFRS 644
            .|:.||..||||:||||||||:||||.|:|:|||||:||||||||||||||||||.::||||||:
Human   565 ALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFILFRT 629

  Fly   645 PEQCPSVVSLLAESYNPHVRYGAAMALGIACAGTGLREAIALLEPMVKFDPVNFVRQGALIASAM 709
            |||||||||||:|||||||||||||||||.|||||.:|||.|||||.. ||||:||||||||||:
Human   630 PEQCPSVVSLLSESYNPHVRYGAAMALGICCAGTGNKEAINLLEPMTN-DPVNYVRQGALIASAL 693

  Fly   710 ILIQHTDQSCPKSTFFRQLYAEVISNKHEDVMAKYGAILAQGIIDAGGRNATLSLQSRTGHTNLQ 774
            |:||.|:.:|||...|||||::||::||:|||||:||||||||:||||.|.|:|||||||||::.
Human   694 IMIQQTEITCPKVNQFRQLYSKVINDKHDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMP 758

  Fly   775 AVVGMLAFTQYWYWFPLAHTLSLAFTPTCVIGLNSDLKMPKMEYKSAAKPSLYAYPAPLEEKKSE 839
            :|||:|.|||:|:||||:|.||||:|||||||||.||||||::|||..|||.:|||||||..|.:
Human   759 SVVGVLVFTQFWFWFPLSHFLSLAYTPTCVIGLNKDLKMPKVQYKSNCKPSTFAYPAPLEVPKEK 823

  Fly   840 EREKVATAVLSIAARQKRRE-NADKKEDEKMDVDEDSKEGAAVKKDEEAKADEKMVTDEKPKKKD 903
            |:|||:||||||.|:.|::| ..:|||:|||:|||                         .:||:
Human   824 EKEKVSTAVLSITAKAKKKEKEKEKKEEEKMEVDE-------------------------AEKKE 863

  Fly   904 EKEKKKEEDKEKEAAGTSSEKDKDKEKDKKEKKEPEPTSEILQNPARVLRQQLKVLSVIDGQSYE 968
            ||||                           ||||||..::|.|||||:..|||||::.:...|:
Human   864 EKEK---------------------------KKEPEPNFQLLDNPARVMPAQLKVLTMPETCRYQ 901

  Fly   969 PLKDVTIGGIIVFQHTGKAED-QELVEPVAAFGP-MNDEEKEPEPPEPFEYIED 1020
            |.|.::|||||:.:.|  :|| :||||||||.|| :.:||:|||||||||||:|
Human   902 PFKPLSIGGIIILKDT--SEDIEELVEPVAAHGPKIEEEEQEPEPPEPFEYIDD 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn2	NP_001263057.1	RPN2	1..1003	CDD:227446	622/1010 (62%)
		PC_rep	456..489	CDD:280095	24/32 (75%)
		PC_rep	526..559	CDD:280095	28/32 (88%)
		HEAT repeat	581..602	CDD:293787	15/20 (75%)
		HEAT repeat	616..639	CDD:293787	18/22 (82%)
		HEAT repeat	651..676	CDD:293787	22/24 (92%)
		PC_rep	666..701	CDD:280095	26/34 (76%)
PSMD1	NP_002798.2	RPN2	2..934	CDD:227446	621/1008 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..318		8/42 (19%)
		PC 1	403..436		22/32 (69%)
		PC 2	441..474		24/32 (75%)
		PC 3	476..510		26/33 (79%)
		PC 4	511..545		29/33 (88%)
		PC 5	547..580		21/32 (66%)
		HEAT repeat	565..590	CDD:293787	17/24 (71%)
		PC 6	581..616		29/34 (85%)
		HEAT repeat	601..624	CDD:293787	18/22 (82%)
		PC 7	617..649		26/31 (84%)
		PC 8	651..685		26/34 (76%)
		HEAT repeat	667..697	CDD:293787	23/30 (77%)
		PC 9	686..726		25/39 (64%)
		PC 10	729..761		23/31 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	839..881		24/93 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..953		16/22 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158970
Domainoid	1	1.000	153	1.000	Domainoid score	I4312
eggNOG	1	0.900	-	-		E1_COG5116
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2100
Inparanoid	1	1.050	1199	1.000	Inparanoid score	I190
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53911
OrthoDB	1	1.010	-	-		D235012at2759
OrthoFinder	1	1.000	-	-		FOG0004235
OrthoInspector	1	1.000	-	-		oto88365
orthoMCL	1	0.900	-	-		OOG6_101410
Panther	1	1.100	-	-	LDO	PTHR10943
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1203
SonicParanoid	1	1.000	-	-		X2978
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800