DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rpn2 and psmd1

DIOPT Version :9

Sequence 1:	NP_001263057.1	Gene:	Rpn2 / 43449	FlyBaseID:	FBgn0028692	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	NP_957478.2	Gene:	psmd1 / 554967	ZFINID:	ZDB-GENE-040426-810	Length:	964	Species:	Danio rerio

Alignment Length:	1023	Identity:	633/1023 - (61%)
Similarity:	800/1023 - (78%)	Gaps:	65/1023 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LTSAAGIISLLDEPMPDLKVFALKKLDNIVDEFWPEISESIEKIEMLHEDRSFPENKLAGMVASK 67
            :||||||||||||..|.||.|||.||:::|::||.|||||:.|||:|:||.:|...:.|.:||||
Zfish     2 ITSAAGIISLLDEDEPQLKEFALHKLNSVVNDFWAEISESVGKIEVLYEDETFRSREFAALVASK 66

  Fly    68 VFYHLGSFEDALTYALGAGDLFDVNARNEYTETIIAKCIDFYIAQRVEFIENPKEASV--VDERL 130
            ||||||:|:::|:|||||||||:||..:||.|||||||||.|..||||..|.|:|...  :|.||
Zfish    67 VFYHLGAFDESLSYALGAGDLFNVNDDSEYVETIIAKCIDHYTKQRVENAELPEEEEKKDIDPRL 131

  Fly   131 EGIVNRMIQRCLDDNQFRQALGIALETRRMDTFKDAIMKSDDVRGMLAYAYNVTMSLIQNRGFRN 195
            |||||:|.||||.|::::||:||||||||:|.|:..|::|:|:.|:|||:..:.|||:||:.|||
Zfish   132 EGIVNKMFQRCLGDHKYKQAIGIALETRRLDIFEKTILESNDIGGLLAYSLKICMSLMQNKKFRN 196

  Fly   196 EVLRCLVSLYRDLGVPDYVNMCQCLIFLEDPFAVAEMLDNLTRSSVETNNLMAYQIAFDLYESAT 260
            ||||.||.||.:|..||::|:|||||||:||.||:::|:.|.:   |.|.||||||.|||||||:
Zfish   197 EVLRVLVKLYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVK---EDNLLMAYQICFDLYESAS 258

  Fly   261 QEFLGNVLQHLKNT-APIPTALPSTFKPQGTTSEDGAKSEGDKSKSDEDITEETPADDKVERTID 324
            |:||.:|:|:|:.. .||| |:|      |:|: .|.....||. ||...||:........:|.|
Zfish   259 QQFLSSVIQNLRTVGTPIP-AVP------GSTN-TGTVPTPDKD-SDSMETEDKAGSSPAGKTAD 314

  Fly   325 SLNEVEKLHQKNIEKLISILSGEVSIDLQLQFLIRSNHADLQVLRGTKEAVRVSICHTATVIANA 389
            :.:|.:..:    .|:|.|||||::|:|.||||||:|:.||.:|:.||:|||.|:|||||||||:
Zfish   315 AKDEPKDQN----SKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAVRNSVCHTATVIANS 375

  Fly   390 FMHSGTTSDQFLRDNLDWLARATNWAKLTATASLGVIHRGHEKDSLALMQSYLPKEAGPSSGYSE 454
            |||:|||||||||:||:||||||||||.||||||||||:||||::|.||.:||||:..|.|.|.|
Zfish   376 FMHTGTTSDQFLRENLEWLARATNWAKFTATASLGVIHKGHEKEALQLMATYLPKDTSPGSAYQE 440

  Fly   455 GGALYALGLIHANHGANIIDYLLQQLKDAQNENVRHGGCLGLGLAGMGTHRQDLYEQLKFNLYQD 519
            ||.||||||||||||.:||||||.|||:|.|:.|||||.||||||.:||.|||:|:.||.|||||
Zfish   441 GGGLYALGLIHANHGGDIIDYLLSQLKNASNDIVRHGGALGLGLAALGTARQDVYDLLKSNLYQD 505

  Fly   520 DAVTGEAAGIAMGMVMLGSKNAQAIEDMVSYAQETQHEKILRGLAVGISLTMFSRLEEADPLVTS 584
            |||||||||:|:|:||||||:||||||||.||||||||||||||||||::.|:.|:||||.|:.|
Zfish   506 DAVTGEAAGLALGLVMLGSKSAQAIEDMVGYAQETQHEKILRGLAVGIAMVMYGRMEEADALIES 570

  Fly   585 LSSDKDPVLRRSGMYTIAMAYNGTGSNKAIRKLLHVAVSDVNDDVRRAAVTAIGFILFRSPEQCP 649
            |..||||:||||||||:||||.|:|:|||||:||||||||||||||||||.:||||:||:|||||
Zfish   571 LCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESIGFIMFRTPEQCP 635

  Fly   650 SVVSLLAESYNPHVRYGAAMALGIACAGTGLREAIALLEPMVKFDPVNFVRQGALIASAMILIQH 714
            ||||||:|||||||||||||||||.|||||.:|||.|||||.. ||||:||||||||||:|:||.
Zfish   636 SVVSLLSESYNPHVRYGAAMALGICCAGTGNKEAINLLEPMTN-DPVNYVRQGALIASALIMIQQ 699

  Fly   715 TDQSCPKSTFFRQLYAEVISNKHEDVMAKYGAILAQGIIDAGGRNATLSLQSRTGHTNLQAVVGM 779
            |:.:|||...|||||::||::||:|||||:|||||||::||||||.|:|||||||||::.:|||:
Zfish   700 TEVTCPKVNQFRQLYSKVINDKHDDVMAKFGAILAQGVLDAGGRNVTISLQSRTGHTHMPSVVGL 764

  Fly   780 LAFTQYWYWFPLAHTLSLAFTPTCVIGLNSDLKMPKMEYKSAAKPSLYAYPAPLEEKKSEEREKV 844
            |.|||:|:||||:|.||||||||.:||||.||||||::|:|..|||.:|||.|||..|.:|:|||
Zfish   765 LVFTQFWFWFPLSHFLSLAFTPTAIIGLNKDLKMPKVQYRSNCKPSTFAYPPPLEVPKEKEKEKV 829

  Fly   845 ATAVLSIAARQKRRENADK-KEDEKMDVDEDSKEGAAVKKDEEAKADEKMVTDEKPKKKDEKEKK 908
            :||||||.|:.|::|...| ||:|||:|                                  |.:
Zfish   830 STAVLSITAKAKKKEKEKKEKEEEKMEV----------------------------------ETQ 860

  Fly   909 KEEDKEKEAAGTSSEKDKDKEKDKKEKKEPEPTSEILQNPARVLRQQLKVLSVIDGQSYEPLKDV 973
            .|.:|||        ||::|||:|::||||||..::::||||.|..|||||::.|...|:|.|.:
Zfish   861 AEAEKEK--------KDEEKEKEKEKKKEPEPNFQMMENPARALPAQLKVLTMPDSCRYQPFKPL 917

  Fly   974 TIGGIIVFQHTGKAEDQELVEPVAAFGP-MNDEEKEPEPPEPFEYIED 1020
            ..||||:.:.|.: |::||||||:|.|| :.:||:|||.|||||||::
Zfish   918 HTGGIIILKDTSE-EEEELVEPVSAHGPKIEEEEQEPEAPEPFEYIDE 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn2	NP_001263057.1	RPN2	1..1003	CDD:227446	621/1004 (62%)
		PC_rep	456..489	CDD:280095	24/32 (75%)
		PC_rep	526..559	CDD:280095	27/32 (84%)
		HEAT repeat	581..602	CDD:293787	15/20 (75%)
		HEAT repeat	616..639	CDD:293787	19/22 (86%)
		HEAT repeat	651..676	CDD:293787	22/24 (92%)
		PC_rep	666..701	CDD:280095	26/34 (76%)
psmd1	NP_957478.2	RPN2	2..945	CDD:227446	620/1002 (62%)
		PC_rep	442..475	CDD:280095	24/32 (75%)
		PC_rep	512..545	CDD:280095	27/32 (84%)
		HEAT repeat	566..591	CDD:293787	17/24 (71%)
		HEAT repeat	602..625	CDD:293787	19/22 (86%)
		PC_rep	652..686	CDD:280095	26/34 (76%)
		HEAT repeat	668..698	CDD:293787	23/30 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594944
Domainoid	1	1.000	508	1.000	Domainoid score	I316
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2100
Inparanoid	1	1.050	1215	1.000	Inparanoid score	I183
OMA	1	1.010	-	-		QHG53911
OrthoDB	1	1.010	-	-		D235012at2759
OrthoFinder	1	1.000	-	-		FOG0004235
OrthoInspector	1	1.000	-	-		oto41124
orthoMCL	1	0.900	-	-		OOG6_101410
Panther	1	1.100	-	-	LDO	PTHR10943
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1203
SonicParanoid	1	1.000	-	-		X2978
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940