DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rpn2 and psmd1

DIOPT Version :9

Sequence 1:	NP_001263057.1	Gene:	Rpn2 / 43449	FlyBaseID:	FBgn0028692	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	XP_012818312.1	Gene:	psmd1 / 407894	XenbaseID:	XB-GENE-989959	Length:	951	Species:	Xenopus tropicalis

Alignment Length:	1022	Identity:	636/1022 - (62%)
Similarity:	795/1022 - (77%)	Gaps:	76/1022 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LTSAAGIISLLDEPMPDLKVFALKKLDNIVDEFWPEISESIEKIEMLHEDRSFPENKLAGMVASK 67
            :||||||:|||||..|.||.|||.||:.:|::||.|||||::|||:|:||.:|...:.|.:||||
Frog     2 ITSAAGILSLLDEEEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDENFRSRQFAALVASK 66

  Fly    68 VFYHLGSFEDALTYALGAGDLFDVNARNEYTETIIAKCIDFYIAQRVEFIE-NPKEASVVDERLE 131
            ||||||:||::|.|||||||||:||..:||.|||||||||.|..|.||..| ...|...:|.|||
Frog    67 VFYHLGAFEESLNYALGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVENAELTDGEKKPIDGRLE 131

  Fly   132 GIVNRMIQRCLDDNQFRQALGIALETRRMDTFKDAIMKSDDVRGMLAYAYNVTMSLIQNRGFRNE 196
            ||||:|.||||||::::||:||||||||:|.|:..|::|:||.|||||:..|.|||:||:.|||:
Frog   132 GIVNKMFQRCLDDHKYKQAIGIALETRRLDVFQKTILESNDVPGMLAYSLKVCMSLMQNKQFRNQ 196

  Fly   197 VLRCLVSLYRDLGVPDYVNMCQCLIFLEDPFAVAEMLDNLTRSSVETNNLMAYQIAFDLYESATQ 261
            |||.||.:|.:|..||::|:|||||||:||.||:::|:.|.|   |.|.||||||.|||||||:|
Frog   197 VLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVR---EDNLLMAYQICFDLYESASQ 258

  Fly   262 EFLGNVLQHLKNT-APIPTALPSTFKPQGTTSEDGAKSEGDKSKSDEDITEETPADDKVERTIDS 325
            :||.:|:|:|:.. ||||:...||    .|.:..||.::.:..:| ||.:..|...:..|...:.
Frog   259 QFLSSVIQNLRTVGAPIPSVPGST----NTGTVPGASADSETMES-EDQSGSTVGSNTAESNPEP 318

  Fly   326 LNEVEKLHQKNIEKLISILSGEVSIDLQLQFLIRSNHADLQVLRGTKEAVRVSICHTATVIANAF 390
            .::        |.|::.|||||::|:|.||||||:|:.||.:|:.||:|||.|:|||||||||:|
Frog   319 KDQ--------ISKMVKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAVRNSVCHTATVIANSF 375

  Fly   391 MHSGTTSDQFLRDNLDWLARATNWAKLTATASLGVIHRGHEKDSLALMQSYLPKEAGPSSGYSEG 455
            ||.||||||||||||:||||||||||.||||||||||:||||::|.||.:||||:..|.|.|.||
Frog   376 MHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEALQLMATYLPKDTSPGSAYQEG 440

  Fly   456 GALYALGLIHANHGANIIDYLLQQLKDAQNENVRHGGCLGLGLAGMGTHRQDLYEQLKFNLYQDD 520
            |.||||||||||||.:||||||.|||:|.|:.||||||||||||.:||.|||:|:.||.||||||
Frog   441 GGLYALGLIHANHGGDIIDYLLNQLKNASNDIVRHGGCLGLGLAALGTARQDVYDLLKTNLYQDD 505

  Fly   521 AVTGEAAGIAMGMVMLGSKNAQAIEDMVSYAQETQHEKILRGLAVGISLTMFSRLEEADPLVTSL 585
            ||||||||:|:|:|||||||||||||||.||||||||||||||||||:|.|:.|:||||.|:.||
Frog   506 AVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVMYGRMEEADALIESL 570

  Fly   586 SSDKDPVLRRSGMYTIAMAYNGTGSNKAIRKLLHVAVSDVNDDVRRAAVTAIGFILFRSPEQCPS 650
            ..||||:||||||||:||||.|:|:|||||:||||||||||||||||||.::||||||:||||||
Frog   571 CRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPS 635

  Fly   651 VVSLLAESYNPHVRYGAAMALGIACAGTGLREAIALLEPMVKFDPVNFVRQGALIASAMILIQHT 715
            |||||:|||||||||||||||||.|:|||.:|||.|||||.. ||||:|||||||:||:|:||.|
Frog   636 VVSLLSESYNPHVRYGAAMALGICCSGTGNKEAINLLEPMTN-DPVNYVRQGALISSALIMIQQT 699

  Fly   716 DQSCPKSTFFRQLYAEVISNKHEDVMAKYGAILAQGIIDAGGRNATLSLQSRTGHTNLQAVVGML 780
            :.:|||.:.|||||::||::||:|||||:||||||||:||||.|.|:|||||||||::.:|||:|
Frog   700 EITCPKVSQFRQLYSKVINDKHDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVL 764

  Fly   781 AFTQYWYWFPLAHTLSLAFTPTCVIGLNSDLKMPKMEYKSAAKPSLYAYPAPLEEKKSEEREKVA 845
            .|||:|:||||:|.||||||||||||||.||||||::|:|..|||.:|||||||..|.:|:|||:
Frog   765 VFTQFWFWFPLSHFLSLAFTPTCVIGLNKDLKMPKVQYRSNCKPSTFAYPAPLEVPKEKEKEKVS 829

  Fly   846 TAVLSIAARQKRRE-NADKKEDEKMDVDEDSKEGAAVKKDEEAKADEKMVTDEKPKKKDEKEKKK 909
            ||||||.|:.|::| ..:|||:|||:|||                         .:||:||
Frog   830 TAVLSITAKAKKKEKEKEKKEEEKMEVDE-------------------------TEKKEEK---- 865

  Fly   910 EEDKEKEAAGTSSEKDKDKEKDKKEKKEPEPTSEILQNPARVLRQQLKVLSVIDGQSYEPLKDVT 974
                                     ||||||..::|:|||||:..||||||:.:|..|:|.|.::
Frog   866 -------------------------KKEPEPNFQLLENPARVMPAQLKVLSMPEGTRYQPFKPLS 905

  Fly   975 IGGIIVFQHTGKAEDQELVEPVAAFGP-MNDEEKEPEPPEPFEYIED 1020
            |||||:.:.|.: |:::|||||||.|| :.:||:|||||||||||:|
Frog   906 IGGIIILRDTSE-EEEQLVEPVAAHGPKIEEEEQEPEPPEPFEYIDD 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn2	NP_001263057.1	RPN2	1..1003	CDD:227446	622/1003 (62%)
		PC_rep	456..489	CDD:280095	24/32 (75%)
		PC_rep	526..559	CDD:280095	28/32 (88%)
		HEAT repeat	581..602	CDD:293787	15/20 (75%)
		HEAT repeat	616..639	CDD:293787	18/22 (82%)
		HEAT repeat	651..676	CDD:293787	22/24 (92%)
		PC_rep	666..701	CDD:280095	25/34 (74%)
psmd1	XP_012818312.1	RPN2	2..932	CDD:227446	621/1001 (62%)
		HEAT repeat	565..590	CDD:293787	17/24 (71%)
		HEAT repeat	601..624	CDD:293787	18/22 (82%)
		HEAT repeat	667..697	CDD:293787	22/30 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	150	1.000	Domainoid score	I4368
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2100
Inparanoid	1	1.050	1223	1.000	Inparanoid score	I189
OMA	1	1.010	-	-		QHG53911
OrthoDB	1	1.010	-	-		D235012at2759
OrthoFinder	1	1.000	-	-		FOG0004235
OrthoInspector	1	1.000	-	-		oto102248
Panther	1	1.100	-	-	LDO	PTHR10943
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1203
SonicParanoid	1	1.000	-	-		X2978
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110