Protein Alignment Rpn2 and psmd1

DIOPT Version :10

• Sequence 1: NP_001263057.1
• Gene: Rpn2 / 43449
• FlyBaseID: FBgn0028692
• Length: 1029
• Species: Drosophila melanogaster
• Sequence 2: XP_012818312.1
• Gene: psmd1 / 407894
• XenbaseID: XB-GENE-989959
• Length: 951
• Species: Xenopus tropicalis
• Alignment Length: 1022
• Identity: 636/1022 - (62%)
• Similarity: 795/1022 - (77%)
• Gaps: 76/1022 - (7%)

  Fly     3 LTSAAGIISLLDEPMPDLKVFALKKLDNIVDEFWPEISESIEKIEMLHEDRSFPENKLAGMVASK 67
            :||||||:|||||..|.||.|||.||:.:|::||.|||||::|||:|:||.:|...:.|.:||||
 Frog     2 ITSAAGILSLLDEEEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDENFRSRQFAALVASK 66

  Fly    68 VFYHLGSFEDALTYALGAGDLFDVNARNEYTETIIAKCIDFYIAQRVEFIE-NPKEASVVDERLE 131
            ||||||:||::|.|||||||||:||..:||.|||||||||.|..|.||..| ...|...:|.|||
 Frog    67 VFYHLGAFEESLNYALGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVENAELTDGEKKPIDGRLE 131

  Fly   132 GIVNRMIQRCLDDNQFRQALGIALETRRMDTFKDAIMKSDDVRGMLAYAYNVTMSLIQNRGFRNE 196
            ||||:|.||||||::::||:||||||||:|.|:..|::|:||.|||||:..|.|||:||:.|||:
 Frog   132 GIVNKMFQRCLDDHKYKQAIGIALETRRLDVFQKTILESNDVPGMLAYSLKVCMSLMQNKQFRNQ 196

  Fly   197 VLRCLVSLYRDLGVPDYVNMCQCLIFLEDPFAVAEMLDNLTRSSVETNNLMAYQIAFDLYESATQ 261
            |||.||.:|.:|..||::|:|||||||:||.||:::|:.|.|   |.|.||||||.|||||||:|
 Frog   197 VLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVR---EDNLLMAYQICFDLYESASQ 258

  Fly   262 EFLGNVLQHLKNT-APIPTALPSTFKPQGTTSEDGAKSEGDKSKSDEDITEETPADDKVERTIDS 325
            :||.:|:|:|:.. ||||:...||    .|.:..||.::.:..:| ||.:..|...:..|...:.
 Frog   259 QFLSSVIQNLRTVGAPIPSVPGST----NTGTVPGASADSETMES-EDQSGSTVGSNTAESNPEP 318

  Fly   326 LNEVEKLHQKNIEKLISILSGEVSIDLQLQFLIRSNHADLQVLRGTKEAVRVSICHTATVIANAF 390
            .::        |.|::.|||||::|:|.||||||:|:.||.:|:.||:|||.|:|||||||||:|
 Frog   319 KDQ--------ISKMVKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAVRNSVCHTATVIANSF 375

  Fly   391 MHSGTTSDQFLRDNLDWLARATNWAKLTATASLGVIHRGHEKDSLALMQSYLPKEAGPSSGYSEG 455
            ||.||||||||||||:||||||||||.||||||||||:||||::|.||.:||||:..|.|.|.||
 Frog   376 MHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEALQLMATYLPKDTSPGSAYQEG 440

  Fly   456 GALYALGLIHANHGANIIDYLLQQLKDAQNENVRHGGCLGLGLAGMGTHRQDLYEQLKFNLYQDD 520
            |.||||||||||||.:||||||.|||:|.|:.||||||||||||.:||.|||:|:.||.||||||
 Frog   441 GGLYALGLIHANHGGDIIDYLLNQLKNASNDIVRHGGCLGLGLAALGTARQDVYDLLKTNLYQDD 505

  Fly   521 AVTGEAAGIAMGMVMLGSKNAQAIEDMVSYAQETQHEKILRGLAVGISLTMFSRLEEADPLVTSL 585
            ||||||||:|:|:|||||||||||||||.||||||||||||||||||:|.|:.|:||||.|:.||
 Frog   506 AVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVMYGRMEEADALIESL 570

  Fly   586 SSDKDPVLRRSGMYTIAMAYNGTGSNKAIRKLLHVAVSDVNDDVRRAAVTAIGFILFRSPEQCPS 650
            ..||||:||||||||:||||.|:|:|||||:||||||||||||||||||.::||||||:||||||
 Frog   571 CRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPS 635

  Fly   651 VVSLLAESYNPHVRYGAAMALGIACAGTGLREAIALLEPMVKFDPVNFVRQGALIASAMILIQHT 715
            |||||:|||||||||||||||||.|:|||.:|||.|||||.. ||||:|||||||:||:|:||.|
 Frog   636 VVSLLSESYNPHVRYGAAMALGICCSGTGNKEAINLLEPMTN-DPVNYVRQGALISSALIMIQQT 699

  Fly   716 DQSCPKSTFFRQLYAEVISNKHEDVMAKYGAILAQGIIDAGGRNATLSLQSRTGHTNLQAVVGML 780
            :.:|||.:.|||||::||::||:|||||:||||||||:||||.|.|:|||||||||::.:|||:|
 Frog   700 EITCPKVSQFRQLYSKVINDKHDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVL 764

  Fly   781 AFTQYWYWFPLAHTLSLAFTPTCVIGLNSDLKMPKMEYKSAAKPSLYAYPAPLEEKKSEEREKVA 845
            .|||:|:||||:|.||||||||||||||.||||||::|:|..|||.:|||||||..|.:|:|||:
 Frog   765 VFTQFWFWFPLSHFLSLAFTPTCVIGLNKDLKMPKVQYRSNCKPSTFAYPAPLEVPKEKEKEKVS 829

  Fly   846 TAVLSIAARQKRRE-NADKKEDEKMDVDEDSKEGAAVKKDEEAKADEKMVTDEKPKKKDEKEKKK 909
            ||||||.|:.|::| ..:|||:|||:|||                         .:||:||
 Frog   830 TAVLSITAKAKKKEKEKEKKEEEKMEVDE-------------------------TEKKEEK---- 865

  Fly   910 EEDKEKEAAGTSSEKDKDKEKDKKEKKEPEPTSEILQNPARVLRQQLKVLSVIDGQSYEPLKDVT 974
                                     ||||||..::|:|||||:..||||||:.:|..|:|.|.::
 Frog   866 -------------------------KKEPEPNFQLLENPARVMPAQLKVLSMPEGTRYQPFKPLS 905

  Fly   975 IGGIIVFQHTGKAEDQELVEPVAAFGP-MNDEEKEPEPPEPFEYIED 1020
            |||||:.:.|.: |:::|||||||.|| :.:||:|||||||||||:|
 Frog   906 IGGIIILRDTSE-EEEQLVEPVAAHGPKIEEEEQEPEPPEPFEYIDD 951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rpn2	NP_001263057.1	RPN2	1..1003	CDD:227446	622/1003 (62%)
		HEAT repeat	581..602	CDD:293787	15/20 (75%)
		HEAT repeat	616..639	CDD:293787	18/22 (82%)
		HEAT repeat	651..676	CDD:293787	22/24 (92%)
psmd1	XP_012818312.1	RPN2	2..932	CDD:227446	621/1001 (62%)
		HEAT repeat	565..590	CDD:293787	17/24 (71%)
		HEAT repeat	601..624	CDD:293787	18/22 (82%)
		HEAT repeat	667..697	CDD:293787	22/30 (73%)