DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slbp and SLBP

DIOPT Version :9

Sequence 1:	NP_477480.1	Gene:	Slbp / 43448	FlyBaseID:	FBgn0041186	Length:	276	Species:	Drosophila melanogaster
Sequence 2:	NP_006518.1	Gene:	SLBP / 7884	HGNCID:	10904	Length:	270	Species:	Homo sapiens

Alignment Length:	228	Identity:	69/228 - (30%)
Similarity:	102/228 - (44%)	Gaps:	51/228 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 HSDEASSSLNSSAASCGSLAKKETADG------NLESKDGEGREMAFEFLDGVNEVKFERLVKEE 107
            |........:..:.:..||.:|..|||      :.|..:..|.|
Human    11 HQSRCDGDASPPSPARWSLGRKRRADGRRWRPEDAEEAEHRGAE--------------------- 54

  Fly   108 KLKTPYKRRHSFTPPSNENSRSNSPNSSNSSANGDAAAPKGGNNPHSRNSKKSGNFRAH---KEE 169
                  :|..|||.|.....||..         .|.|:....:...:|.:|:...::..   .:.
Human    55 ------RRPESFTTPEGPKPRSRC---------SDWASAVEEDEMRTRVNKEMARYKRKLLINDF 104

  Fly   170 KRVRHNSYTSSTSSSSSYT-----EADPAILSRRQKQIDYGKNTAAYERYVEMVPKDERTRD-HP 228
            .|.|.:|..||.|..|..|     |.|.::|.||||||:|||||.||:||::.||:..|... ||
Human   105 GRERKSSSGSSDSKESMSTVPADFETDESVLMRRQKQINYGKNTIAYDRYIKEVPRHLRQPGIHP 169

  Fly   229 RTPNKYGKYSRRAFDGLVKIWRKSLHIYDPPTQ 261
            :||||:.|||||::|..:|:|:.:||.:|||.:
Human   170 KTPNKFKKYSRRSWDQQIKLWKVALHFWDPPAE 202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slbp	NP_477480.1	SLBP_RNA_bind	191..256	CDD:291900	36/65 (55%)
SLBP	NP_006518.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..132		30/156 (19%)
		Nuclear localization signal NLS1	31..34		1/2 (50%)
		Nuclear localization signal NLS2	96..99		0/2 (0%)
		RNA-binding	129..198		37/68 (54%)
		SLBP_RNA_bind	130..198	CDD:405844	36/67 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..241
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157024
Domainoid	1	1.000	87	1.000	Domainoid score	I8019
eggNOG	1	0.900	-	-		E1_KOG3934
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I5013
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003353
OrthoInspector	1	1.000	-	-		oto90698
orthoMCL	1	0.900	-	-		OOG6_103940
Panther	1	1.100	-	-	O	PTHR17408
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2795
SonicParanoid	1	1.000	-	-		X2243
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.870