DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and NPEPPS

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	XP_016880861.1	Gene:	NPEPPS / 9520	HGNCID:	7900	Length:	924	Species:	Homo sapiens

Alignment Length:	904	Identity:	272/904 - (30%)
Similarity:	457/904 - (50%)	Gaps:	80/904 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 RLPHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLEDCYNITMHAEELNI------SRSDASVH 171
            |||..:.|:.|::.::|.|. :|||.|.::...:|.:....|.|:..:::|      ...|..:|
Human    53 RLPADVSPINYSLCLKPDLL-DFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIH 116

  Fly   172 RVQNNGEPEGDGLRIHKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQGFYRSSYEV 236
            ....|.:.|.:.:.:.               :...|:.....:.:.|.|.:.|.::|||||.|..
Human   117 ATGFNYQNEDEKVTLS---------------FPSTLQTGTGTLKIDFVGELNDKMKGFYRSKYTT 166

  Fly   237 -HNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSSNDHATMPSYV 300
             ..|.|:.|.|||:||||||||||:||||:||.|.:.:..|::...:|||.::....:....:.|
Human   167 PSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLV 231

  Fly   301 WDHFAESLPMSTYLVAYAISDFTHISSGN-----FAVWARADAIKSAEYALSVGPRILTFLQDFF 360
            ...||.:..|||||||:.:.::..:.:.:     ..|:......:..::||.|..:.|.|.:|:|
Human   232 EVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYF 296

  Fly   361 NVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQWFGN 425
            ||.:||||||:||:.:|.|||||||||:|:||||:|.||..:.::::|.||.|||||||||||||
Human   297 NVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGN 361

  Fly   426 LVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDALSTSHKISHEVFNP 490
            |||..||:.:||||||||::|||..|...||:....|||..:.....:||||..||.|...|.:|
Human   362 LVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHP 426

  Fly   491 QEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLWHFLTVEAKSSGL 555
            .|:.||||.|||:||:::|||:..::.:..|::|::.||.:....:|..:|||..|   ..:||
Human   427 SEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESL---ENASG- 487

  Fly   556 LDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSD--VIRLEQVRFVYTNTTREDESLLWYIPITFTT 618
                :.:..:|:|||.|.|:|::.|......|  ::||.|.:|....:...::...|.:|||.:|
Human   488 ----KPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQWMVPITIST 548

  Fly   619 DSELNFANTRPTTWMPRTKLYELENRELSLAKWFIFNVQQTGYYRVNYDLENWMAITEHLMDVDN 683
            ..:.|.|..:.....|...:. |:|  :...:|...|:...|:||..|.    .|:.|.|:....
Human   549 SEDPNQAKLKILMDKPEMNVV-LKN--VKPDQWVKLNLGTVGFYRTQYS----SAMLESLLPGIR 606

  Fly   684 FEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAISNFIFIDSMFVNSGD 748
            ...:.|.:|..|.:|:.:|||...:|....:.:.....:|..:..|.....|...:.::..::..
Human   607 DLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDF 671

  Fly   749 YDLLKNYLLKQLKKVYDQVGFKDSQD--ESEDILVKLKRADILSMACHLGHQECIAEASRHFQNW 811
            |:.::.:    :|.|:..:|.:...|  ..|..|..|.|..:|......||:..:.||.|.|::
Human   672 YEEIQEF----VKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFKD- 731

  Fly   812 MQTPNPDSNNPIVPNLRGVVYCSAIQYGTEYEWDFAFERFLKTNVPGEKDLLLNALGCSKEPWLL 876
                :.:....:..:||..||.:.:::|.....|...:...:.::..||:.:...||.:..|.|:
Human   732 ----HVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLI 792

  Fly   877 YRFLRRGISGQHIRKQDLFRVFAAVS-TTVVGQNIAFDFLRNNWQEI-KTYMGSQMSSIHTLFKF 939
            .:.|...:| :.:|.||...|...|: .:..|:..|:.|:::||:|: ..|.|..:.|.....::
Human   793 QKVLTFALS-EEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQGGFLISRLIKVQW 856

  Fly   940 ATKGFNSKFQLGEFENFVKDAHWDYDRPVQQIVEHIETSVDWMNKNYK----SIVRWLE 994
            .|.              |..|.||.:  |.:..|...:.:.|.. .|:    .:::|||
Human   857 LTP--------------VIPALWDAE--VGRSPEVGSSRLSWPT-CYQLRDLQLIKWLE 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	157/403 (39%)
		M1_APN_2	121..576	CDD:189008	175/466 (38%)
		ERAP1_C	652..974	CDD:288671	69/325 (21%)
NPEPPS	XP_016880861.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820