Protein Alignment superdeath and AAP1

DIOPT Version :10

• Sequence 1: NP_651674.3
• Gene: superdeath / 43444
• FlyBaseID: FBgn0039640
• Length: 999
• Species: Drosophila melanogaster
• Sequence 2: NP_011913.1
• Gene: AAP1 / 856443
• SGDID: S000001089
• Length: 856
• Species: Saccharomyces cerevisiae
• Alignment Length: 926
• Identity: 284/926 - (30%)
• Similarity: 461/926 - (49%)
• Gaps: 114/926 - (12%)

  Fly   110 RDVRLPHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLEDCYN--------ITMH--------A 158
            |:| ||:::.||.|:||:||.... |||.||::|.:::.:...|        |..|        |
Yeast     3 REV-LPNNVTPLHYDITLEPNFRA-FTFEGSLKIDLQINDHSINSVQINYLEIDFHSARIEGVNA 65

  Fly   159 EELNISRSDASVHRVQNNGEPEGDGLRIHKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDGIIE 223
            .|:|.:.:......|..||..|..|        ..||                  :.:.|.||:.
Yeast    66 IEVNKNENQQKATLVFPNGTFENLG--------PSAK------------------LEIIFSGILN 104

  Fly   224 DYLQGFYRSSY--EVHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMP 286
            |.:.||||:.|  :|..||:::|:||.:||||||||||||||.|||.|.:.:.....:|.:|||.
Yeast   105 DQMAGFYRAKYTDKVTGETKYMATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTHLSNMD 169

  Fly   287 IVSSNDHATMPSYVWDHFAESLPMSTYLVAYAISDFTHISSGNFAVWARADAI----KSAEYALS 347
            :   .:........:..|..:..|||||||:.::|..::.|.||.:..|..:.    |..::|.:
Yeast   170 V---RNETIKEGKKYTTFNTTPKMSTYLVAFIVADLRYVESNNFRIPVRVYSTPGDEKFGQFAAN 231

  Fly   348 VGPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVAS 412
            :..|.|.|.:|.||:.:||||:||:|:.||.|||||||||:|:|...:|.|...::.:..||||.
Yeast   232 LAARTLRFFEDTFNIEYPLPKMDMVAVHEFSAGAMENWGLVTYRVIDLLLDIENSSLDRIQRVAE 296

  Fly   413 VVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDAL 477
            |:.|||||||||||||..||..:|||||||::|.:.:.:...||||..:|:|.:.||....||:|
Yeast   297 VIQHELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNKFQPEWKVWEQYVTDNLQRALNLDSL 361

  Fly   478 STSHKISHEVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDL 542
            .:||.|...|.|..||::|||.|||:|||:::||::.:|....|.:|:|:||.:..|.:|...||
Yeast   362 RSSHPIEVPVNNADEINQIFDAISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGDL 426

  Fly   543 WHFLTVEAKSSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVYTNTTREDES 607
            |..|   |.:||     :.|..:|:.||.:.|:||:.|..|.|.  |.|.|.|::.|...:|:|.
Yeast   427 WDAL---ADASG-----KDVCSVMNIWTKRVGFPVLSVKEHKNK--ITLTQHRYLSTGDVKEEED 481

  Fly   608 LLWYIPITFTTDSELNFANTRPTTWMPRTKLYELENRELSLAKWFIFNVQQTGYYRVNYDLENWM 672
            ...| ||...........||  .....::..:||:|.|     :|..|..|:|.:..:|..|.|.
Yeast   482 TTIY-PILLALKDSTGIDNT--LVLNEKSATFELKNEE-----FFKINGDQSGIFITSYSDERWA 538

  Fly   673 AITE--HLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAI-- 733
            .:::  :|:.|:        :|..|:.|...|:...|.|....:||.....:|...|.|:..|
Yeast   539 KLSKQANLLSVE--------DRVGLVADAKALSASGYTSTTNFLNLISNWKNEDSFVVWEQIINS 595

  Fly   734 -----SNFIFIDSMFVNSGD---YDLLKNYLLKQLKKVYDQVGFKDSQDESEDILVKLKRADILS 790
                 |.::|.....:|:.|   .||:.|.|        .::|:...:|:|  ..::..:..:.|
Yeast   596 LSALKSTWVFEPEDILNALDKFTLDLVLNKL--------SELGWNIGEDDS--FAIQRLKVTLFS 650

  Fly   791 MACHLGHQECIAEASRHFQNWMQTPNPDSNNPIVPNL-RGVVYCSAIQYGTEYEWDFAFERFLKT 854
            .||..|:::..:.|...|:.:     .:.|...:|.| :.||:.:..:.|.|..::..|..:...
Yeast   651 AACTSGNEKMQSIAVEMFEEY-----ANGNKQAIPALFKAVVFNTVARLGGENNYEKIFNIYQNP 710

  Fly   855 NVPGEKDLLLNALGCSKEPWLLYRFLRRGISGQHIRKQDLFRVFAAVSTTVVGQNIAFDFLRNNW 919
            ....||.:.|.|||..::..||.|.|...:.|. :..||.:.....:.....|....:.:::.:|
Yeast   711 VSSEEKIIALRALGRFEDKELLERTLSYLLDGT-VLNQDFYIPMQGIRVHKKGIERLWAWMQEHW 774

  Fly   920 QEI--KTYMGSQ-MSSIHTLFKFATKGFNSKFQLGEFENFVKDAHWDYDRPVQQIVEHIETSVDW 981
            .||  :...||. :..:.||.......|.:..::..|  :.:.....:|:.:.|.::.|.:...|
Yeast   775 DEIAKRLQPGSPVLGGVLTLGLTNFTSFEALEKISAF--YSRKVTKGFDQTLAQALDTIRSKAQW 837

  Fly   982 MNKNYKSIVRWL-ENE 996
            ::::.:.:..:| |:|
Yeast   838 VSRDREIVATYLREHE 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
superdeath	NP_651674.3	M1_APN-Q_like	121..571	CDD:341064	180/471 (38%)
		ERAP1_C	651..976	CDD:463368	71/340 (21%)
AAP1	NP_011913.1	M1_APN-Q_like	13..447	CDD:341064	180/471 (38%)
		ERAP1_C	517..833	CDD:463368	72/341 (21%)