DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and LAP2

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_014353.1	Gene:	LAP2 / 855682	SGDID:	S000004990	Length:	671	Species:	Saccharomyces cerevisiae

Alignment Length:	773	Identity:	155/773 - (20%)
Similarity:	263/773 - (34%)	Gaps:	264/773 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 TPKYD-------RDVRLPHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLEDCYNITMHAEELN 162
            :|:||       :|..:.|:  .|..:::.|..     ..:|||..:::.|.:..|   .::||:
Yeast    53 SPEYDQSTLSNYKDFAVLHT--DLNLSVSFEKS-----AISGSVTFQLKKLHEGKN---KSDELH 107

  Fly   163 ISRSDASVHRVQNNG-----------EPEGDGLRIHKQYLVGAKQFFVIELY----DKLLKDVEY 212
            :..|...|..|..:|           ||.|..|.|:.   ......|.:.:.    ||...
Yeast   108 LDTSYLDVQEVHIDGSKADFQIEQRKEPLGSRLVINN---ASCNDNFTLNIQFRTTDKCTA---- 165

  Fly   213 VVHLRFDGIIEDYLQGFYRSSYEVHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPR 277
                         ||  :.:|.:......:|.| |.:|..||..|||||.|::|:.||..|..|
Yeast   166 -------------LQ--WLNSKQTKGGKPYVFS-QLEAIHARSLFPCFDTPSVKSTFTASIESP- 213

  Fly   278 NMTTISNMPIVSSN---DHATMPSYVWDHFAESLPMSTYLVAYAISDFTHISSG-NFAVWARADA 338
                   :|:|.|.   :..:..:.:: .|.:.:|:..||:..|..|.:....| ...|:.....
Yeast   214 -------LPVVFSGIRIEDTSKDTNIY-RFEQKVPIPAYLIGIASGDLSSAPIGPRSTVYTEPFR 270

  Fly   339 IKSAEYALSVGPRILTFLQDFFNVTFP--------LPKIDMIALPEFQAGAMENWGLITFRETAM 395
            :|..::...  ..:..|:|....:.|.        |..:|     .:..|.||:..: ||....:
Yeast   271 LKDCQWEFE--NDVEKFIQTAEKIIFEYEWGTYDILVNVD-----SYPYGGMESPNM-TFATPTL 327

  Fly   396 LYDPGVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPE---- 456
            :       |:::..: .|:.|||||.|.|||||...|:..|||||:..|:|.....|:..|
Yeast   328 I-------AHDRSNI-DVIAHELAHSWSGNLVTNCSWNHFWLNEGWTVYLERRIIGAIHGEPTRH 384

  Fly   457 ------WKQLDQFVVNELQAVFQLDALSTSHKISHEVFNPQEISEIFDRISYAKG-------STI 508
                  |..|.    |.:.::...:..||..:..::..:|   .:.|..:.|.||       .||
Yeast   385 FSALIGWSDLQ----NSIDSMKDPERFSTLVQNLNDNTDP---DDAFSTVPYEKGFNLLFHLETI 442

  Fly   509 IRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLWHFLTVEAKSSGLLDDSRSVKEIMD-----T 568
            :...|.|  :|..|....|:.::........|.|:.|...:             |||:|     |
Yeast   443 LGGKAEF--DPFIRHYFKKFAKKSLDTFQFLDTLYEFYPEK-------------KEILDSVDWET 492

  Fly   569 WTLQTGYPVVKVSRHPNSDVIRLEQVRFVYTNTTREDESLLWYIPITFTTDSELNFANTRPTTWM 633
            |..:.|.|               .:..|                 ||...|:
Yeast   493 WLYKPGMP---------------PRPHF-----------------ITALADN------------- 512

  Fly   634 PRTKLYELENRELSLAKWFIFNVQQTGYYRVNYDLENWMAITEHLMDVDNFE------DIAPANR 692
                :|:|.::                          |:.:.:||...::|.      ||...|.
Yeast   513 ----VYQLADK--------------------------WVEMAQHLKTTEDFRSEFNAIDIKDFNS 547

  Fly   693 AQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAISNFIFIDSMFVNSGDYDLLK-NYL 756
            .||:           |..||   ||     :.||...|..               |:|..| ...
Yeast   548 NQLV-----------LFLET---LT-----QNGHSNKKPK---------------DFDWAKFPVA 578

  Fly   757 LKQLKKVYDQVGFKDSQDESEDILVKLKRADILSMACHLGHQECIAEASRHFQNWMQT 814
            .:.|..:|            :|.:||.:.|:::...........:.|..:|..:|:.|
Yeast   579 SRALLDIY------------QDNIVKSQNAEVVFKMFKFQIFAKLQEEYKHLADWLGT 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	95/428 (22%)
		M1_APN_2	121..576	CDD:189008	113/503 (22%)
		ERAP1_C	652..974	CDD:288671	30/170 (18%)
LAP2	NP_014353.1	leuko_A4_hydro	57..669	CDD:274120	153/769 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810