Protein Alignment superdeath and TMA108

DIOPT Version :10

• Sequence 1: NP_651674.3
• Gene: superdeath / 43444
• FlyBaseID: FBgn0039640
• Length: 999
• Species: Drosophila melanogaster
• Sequence 2: NP_012129.1
• Gene: TMA108 / 854669
• SGDID: S000001399
• Length: 946
• Species: Saccharomyces cerevisiae
• Alignment Length: 979
• Identity: 211/979 - (21%)
• Similarity: 387/979 - (39%)
• Gaps: 210/979 - (21%)

  Fly   109 DRDVRLPHSIRPLKYNITIE---PQLSGNFTFAGSVQIRIRV---------LEDCY-NITMHAEE 160
            |..:.|.:.:.|..|.:.:|   .|.|.|  |.||..|.::.         :||.: ...:|:::
Yeast     3 DNLLSLENPVVPSHYELRLEIDPKQSSPN--FKGSAIIHLKFNPNSTTLASIEDSFTQFKLHSKD 65

  Fly   161 LNISRSDASVHRVQNNGEPEGDGLRIHK---QYLVGAKQFFVIELYD--KLLKDVEYVVHLRFDG 220
            |.:..:.|::      |..:.| |:|.:   ::|........|:|.:  .|:..|:||..:|...
Yeast    66 LIVLSAHATI------GSTKFD-LKISQDTGKHLSIFNSESPIQLSNDCPLILSVQYVGKIRDIK 123

  Fly   221 IIEDYLQGFYRSSY---EVHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTI 282
            ...|...|.:::::   :.......|.:|..|...|...|||.|||:.|:.|.|:||.......:
Yeast   124 THHDKTFGIFKTNFMDRKTGTANNHVVATHCQPFSASNIFPCIDEPSNKSTFQLNIATDAQYKAV 188

  Fly   283 SNMPIV------SSNDHATMPSYVWDHFAESLPMSTYLVAYAISDFTHISS-----GN------- 329
            ||.|:.      ||..|..       .||::..|:|.:..::|.|...:.:     |:
Yeast   189 SNTPVEMVEALDSSQKHLV-------KFAKTPLMTTSVFGFSIGDLEFLKTEIKLEGDRTIPVSI 246

  Fly   330 FAVWARADAIKSAEYALSVGPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETA 394
            :|.|    .|.:|.:.|....:.|..|:.:|...:||||:|.:.||.....||||:|:||.:...
Yeast   247 YAPW----DIANAAFTLDTVQKYLPLLESYFKCPYPLPKLDFVLLPYLSDMAMENFGMITIQLNH 307

  Fly   395 MLYDPGVATANN--KQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYM--EYLTADAVAP 455
            :|..|. |.||.  :::...::.|||.|||.||.::...|..:|.||.||:::  ..|..:....
Yeast   308 LLIPPN-ALANETVREQAQQLIVHELVHQWMGNYISFDSWESLWFNESFATWLACHILEQNGDLS 371

  Fly   456 EWKQLDQFVVNELQAVFQLDALSTSHKISHEVFN-----PQEISEIFDRISYAKGSTIIRMMAHF 515
            .:...:.:::.:::.....||...:.:...::..     ..:.|:|||..:|.||..::|.:...
Yeast   372 HYWTSEPYLLQQVEPTMCRDAADVNGRSIFQIAQRNTGIDSQTSDIFDPEAYTKGIIMLRSLQLA 436

  Fly   516 LTNPIFRRGLSKYLQE---MAYNSATQDDLWHFLTVEAKSSGLLDDSRSVKEIMDTWTLQTGYPV 577
            ......::||....::   ....|....|:|:.:       |....|:::...:.:||...|.||
Yeast   437 TGESHLQKGLESVFEDTKTFHARSVKPMDIWNHI-------GKFLKSQNITNFVSSWTRTPGLPV 494

  Fly   578 VK--VSRHPNSDVIRLEQVRFVYTNTTRED---ESLLWYIPI-TFTTDSELNFANTRPTTWMPRT 636
            ||  |.........:|.|.||:...:|.|.   |.:.:.:|: ....|.:::            |
Yeast   495 VKVEVEEKDGKTQTKLTQHRFINQLSTEEKDQLEDVPYQVPLFGVLPDGKMD------------T 547

  Fly   637 KLYELENRELSL-AKWFIFNVQQTGYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLIDDVM 700
            |...|.:|.|.. ....:.|....|||||:|:.|...|:....:..:...:|          |:.
Yeast   548 KNVLLTDRTLKFDYPILVINHLAQGYYRVSYESEECYALINDKITEETLSEI----------DLR 602

  Fly   701 NLARGSYLSYETAMNLTRYLGHELG-----HVPWKAAISNFIFIDSMFVNSGDYDLLKNYLLKQL 760
            .:          .::|::::|.| |     |:.....|.|.|...|..:.|..:|.|...|  ::
Yeast   603 KI----------FLDLSQFIGDE-GFQNSIHLHGLFKILNHIASPSTKIASKYWDPLSKGL--EV 654

  Fly   761 KKVYDQVGFKDSQDES---EDILVKL-KRAD----------------ILSMACHLGHQ--ECIAE 803
            .:..|:.....|:.:|   :.|::.| .:.|                ::|....|...  :|...
Yeast   655 LQTIDRASLTSSKLQSFLKKKIVIPLFNKIDWPHGEFDKSTNPHELKVMSQVLFLNKNSAKCAEL 719

  Fly   804 ASRHFQNWMQTPNPDSNNPIVPNLRGVV--YCSAIQYGTEYEWDFAFERFLKTNVPGEKDLLLNA 866
            ...:|::.:|.|.......:|.::..||  :|:.|:     :|...|:             |:..
Yeast   720 CQIYFKHLLQGPRSSVPLELVNSILVVVSQHCANIK-----QWKKIFD-------------LVKR 766

  Fly   867 LGCSKEPWLLYRFLRRGISGQHIRKQDLFRVFAAVSTTVVGQNIAF---------DFLRNNWQEI 922
            ..|:            ||:...|...|.    .:..|.::.||.|.         |.::.....|
Yeast   767 SSCT------------GITNHVINMYDQ----NSSETAMLIQNGAIESLGFCLDSDIVKKTLNFI 815

  Fly   923 KTYMGSQMSSIHTLFKFATKGFNSKFQLGEFENFVKDAHWDYDRPVQQIVEHIETSVDWMNKNYK 987
            .:.:.|:...: .||     |||..|:....:|         ::|..|:|.  ||..:|...|:.
Yeast   816 TSNIESEGMEL-ALF-----GFNYNFKKRLNKN---------EKPQDQVVR--ETIWEWYMGNFD 863

  Fly   988 SIVR 991
            ...|
Yeast   864 QWAR 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
superdeath	NP_651674.3	M1_APN-Q_like	121..571	CDD:341064	116/500 (23%)
		ERAP1_C	651..976	CDD:463368	66/362 (18%)
TMA108	NP_012129.1	M1_APN-Q_like	15..488	CDD:341064	116/500 (23%)
		ERAP1_C	564..924	CDD:463368	71/378 (19%)