DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and APE2

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_012765.3	Gene:	APE2 / 853699	SGDID:	S000001640	Length:	952	Species:	Saccharomyces cerevisiae

Alignment Length:	919	Identity:	274/919 - (29%)
Similarity:	454/919 - (49%)	Gaps:	96/919 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 TPKYDRDVRLPHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLEDCYNITMHAEELNISRSDAS 169
            ||  :|:: ||.::.||.|::|:||... .|.|.|||:|.:::....      .:.:.::..|..
Yeast    96 TP--NREI-LPDNVVPLHYDLTVEPDFK-TFKFEGSVKIELKINNPA------IDTVTLNTVDTD 150

  Fly   170 VHRVQNNGEPEGDGLRIHKQYLV------GAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQG 228
            :|..:.......:.:...:|.:.      |....|....:          :.::|.||:.|.:.|
Yeast   151 IHSAKIGDVTSSEIISEEEQQVTTFAFPKGTMSSFKGNAF----------LDIKFTGILNDNMAG 205

  Fly   229 FYRSSYE--VHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSSN 291
            |||:.||  :..||:::|:||.:.|||||||||||||.|||:|.:.:....::|.:|||.:.:
Yeast   206 FYRAKYEDKLTGETKYMATTQMEPTDARRAFPCFDEPNLKASFAITLVSDPSLTHLSNMDVKN-- 268

  Fly   292 DHATMPSYVWDH-----FAESLPMSTYLVAYAISDFTHISSGNFAVWARADAI----KSAEYALS 347
                  .||.|.     |..:..|||||||:.:::..::.|.||.:..|..|.    |..::|..
Yeast   269 ------EYVKDGKKVTLFNTTPKMSTYLVAFIVAELKYVESKNFRIPVRVYATPGNEKHGQFAAD 327

  Fly   348 VGPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVAS 412
            :..:.|.|.:..|.:.:||||:|.:|:.||.|||||||||:|:|...:|.|...:|.:..||||.
Yeast   328 LTAKTLAFFEKTFGIQYPLPKMDNVAVHEFSAGAMENWGLVTYRVVDLLLDKDNSTLDRIQRVAE 392

  Fly   413 VVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDAL 477
            ||.|||||||||||||..||..:|||||||::|.:.:.:...||||..:|:|.:.||....||:|
Yeast   393 VVQHELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNEFQPEWKVWEQYVTDTLQHALSLDSL 457

  Fly   478 STSHKISHEVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDL 542
            .:||.|...|....||::|||.|||:||::::||::.:|....|.:|:|:||.:..|.:|..:||
Yeast   458 RSSHPIEVPVKKADEINQIFDAISYSKGASLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTEDL 522

  Fly   543 WHFLTVEAKSSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVYTNTTREDES 607
            |..|   |.:||     :.|:.:|:.||.:.|:||:.||...|.. |...|.|::.|...:.||.
Yeast   523 WDAL---ADASG-----KDVRSVMNIWTKKVGFPVISVSEDGNGK-ITFRQNRYLSTADVKPDED 578

  Fly   608 LLWYIPITFT------TDSELNFANTRPTTWMPRTKLYELENRELSLAKWFIFNVQQTGYYRVNY 666
            ...| |:...      .||.:..:.        |:|..|||:     ..:|..|.:|:|.|..:|
Yeast   579 KTIY-PVFLALKTKNGVDSSVVLSE--------RSKTIELED-----PTFFKVNSEQSGIYITSY 629

  Fly   667 DLENWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKA 731
            ..|.|..:.:. .|:.:.||     |..|:.||..|:...|.|....:||.....:|...|.|..
Yeast   630 TDERWAKLGQQ-ADLLSVED-----RVGLVADVKTLSASGYTSTTNFLNLVSKWNNEKSFVVWDQ 688

  Fly   732 AISNFIFIDS--MFVNSGDYDLLKNYLLKQLKKVYDQVG--FKDSQDESEDILVKLKRADILSMA 792
            .|::...:.|  :|......|.|.|:..:.:..:...:|  ||.|...|...|    :..:...|
Yeast   689 IINSISSMKSTWLFEPKETQDALDNFTKQLISGMTHHLGWEFKSSDSFSTQRL----KVTMFGAA 749

  Fly   793 CHLGHQECIAEASRHFQNWMQTPNPDSNNPIVPNL-RGVVYCSAIQYGTEYEWDFAFERFLKTNV 856
            |.....:....|.:.|.::.     ..|...:|.| :.:|:.:..:.|....::..::.:|....
Yeast   750 CAARDADVEKAALKMFTDYC-----SGNKEAIPALIKPIVFNTVARVGGAENYEKVYKIYLDPIS 809

  Fly   857 PGEKDLLLNALGCSKEPWLLYRFLRRGISGQHIRKQDLFRVFAAVSTTVVGQNIAFDFLRNNWQE 921
            ..||...|.:||..|||.||.|.|.....|. :..||::.....:.....|....:::::.||.|
Yeast   810 NDEKLAALRSLGRFKEPKLLERTLGYLFDGT-VLNQDIYIPMQGMRAHQEGVEALWNWVKKNWDE 873

  Fly   922 IKTYMGSQMSSIHTLFKFATKGFNSKFQLGEFEN-FVKDAHWDYDRPVQQIVEHIETSVDWMNKN 985
            :...:...:|.:.::....|.||.|..::.|.:. |...:...:|:.:.|.::.|.:...|:|::
Yeast   874 LVKRLPPGLSMLGSVVTLGTSGFTSMQKIDEIKKFFATKSTKGFDQSLAQSLDTITSKAQWVNRD 938

  Fly   986 YKSIVRWLE 994
            ...:.::|:
Yeast   939 RDVVNKYLK 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	150/408 (37%)
		M1_APN_2	121..576	CDD:189008	171/471 (36%)
		ERAP1_C	652..974	CDD:288671	73/327 (22%)
APE2	NP_012765.3	PepN	90..941	CDD:223385	273/911 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I1338
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
TreeFam	0	0.000	Not matched by this tool.
	6	5.910