DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14516 and Erap1

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_109636.1	Gene:	Erap1 / 80898	MGIID:	1933403	Length:	930	Species:	Mus musculus

Alignment Length:	952	Identity:	329/952 - (34%)
Similarity:	515/952 - (54%)	Gaps:	91/952 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 CTSYHLRRLKAGHDDTPKYDRDVRLPHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLEDCYNI 154
            |.:..:..|||.:.|:..:: ::|||..:.|:.|::.|...|| ..||.|..::.|........|
Mouse    20 CQNSDIESLKASNGDSFPWN-NMRLPEYMTPIHYDLMIHANLS-TLTFWGKTEVEIIASRPTSTI 82

  Fly   155 TMHAEELNISRSDASVHRVQNNGEP-EGDGLRI-----HKQYLVGAKQFFVIELYDKLLKDVEYV 213
            .||:..|.||:  |::.|  ..||. ..:.|::     |:|..:.|.|        .||....|.
Mouse    83 IMHSHHLQISK--ATLRR--GAGEMLSEEPLKVLEYPAHEQVALLAAQ--------PLLAGSLYT 135

  Fly   214 VHLRFDGIIEDYLQGFYRSSYEV-HNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIAR-P 276
            |.:.:...:.:...|||:|:|.. ..|.|.:|:|||:.|.||.||||||||||||:|::.|.| |
Mouse   136 VIIDYAANLSESFHGFYKSTYRTQEGEMRILAATQFEPTAARMAFPCFDEPALKASFSIKIKRDP 200

  Fly   277 RNMTTISNMPIVSSNDHATMPSYVWDHFAESLPMSTYLVAYAISDFTHIS----SG-NFAVWARA 336
            |:: .|||||:|.|.:.|  ...:.|||..::.|||||||:.||||..:|    || ..:|:|..
Mouse   201 RHL-AISNMPLVKSVNVA--EGLIEDHFDITVKMSTYLVAFIISDFKSVSKMTKSGVKVSVYAVP 262

  Fly   337 DAIKSAEYALSVGPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGV 401
            |.|..|:|||.....:|.|.:|:||:.:||||.|:.|:|:||:||||||||.|:||:::|||...
Mouse   263 DKINQADYALDAAVTLLEFYEDYFNIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESSLLYDKEK 327

  Fly   402 ATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVN 466
            ::|::|..:..:|.|||||||||||||..||:|:|||||||.:||:::.....||.|..|.|...
Mouse   328 SSASSKLGITMIVSHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVTVTHPELKVEDYFFGK 392

  Fly   467 ELQAVFQLDALSTSHKISHEVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQE 531
            ...|: ::|||::||.:|..|.||.:|.|:||.:||.||:.|:.|:..:|:...|:||:.:|||:
Mouse   393 CFNAM-EVDALNSSHPVSTPVENPAQIREMFDDVSYEKGACILNMLRDYLSADTFKRGIVQYLQK 456

  Fly   532 MAYNSATQDDLWHFLTVEAKSSG--LLDD--SRS---------------VKEIMDTWTLQTGYPV 577
            .:|.:...:|||:.:.....:.|  .:|.  |||               ||.:|:|||||.|:|:
Mouse   457 YSYKNTKNEDLWNSMMHICPTDGTQTMDGFCSRSQHSSSTSHWRQEVVDVKTMMNTWTLQKGFPL 521

  Fly   578 VKVSRHPNSDVIRLEQVRFVYTNTTREDESLLWYIPITFTT---DSELNFANTRPTTWMPRTKLY 639
            :.::....:  :.::|..::..:....:...||::|:||.|   ||...|        :.:||..
Mouse   522 ITITVSGRN--VHMKQEHYMKGSERFPETGYLWHVPLTFITSKSDSVQRF--------LLKTKTD 576

  Fly   640 ELENRELSLAKWFIFNVQQTGYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLAR 704
            .|...|  ..:|..|||...|||.|:|..:.|.:::..|.:...  .|:..:||.||::...|..
Mouse   577 VLILPE--AVQWIKFNVGMNGYYIVHYADDGWASLSGLLKEAHT--TISSNDRASLINNAFQLVS 637

  Fly   705 GSYLSYETAMNLTRYLGHELGHVPWKAAISNFIFIDSMFVNSGDYDLL------KNYLLKQLKKV 763
            ...||.|.|::||.||.:|...:|...|::..|   .|:......|::      |::|||.||.:
Mouse   638 IEKLSIEKALDLTLYLKNETEIMPIFQALNELI---PMYKLMEKRDMIEVETQFKDFLLKLLKDL 699

  Fly   764 YDQVGFKDSQDESEDILVKLKRADILSMACHLGHQECIAEASRHFQNWMQTPNPDSNNPIVPNLR 828
            .|:..:.|....||.:|    |:.:|.:||...:|.|:..|.|:|:.| ::.|.:.:.||...|
Mouse   700 IDKQTWTDEGSVSERML----RSQLLLLACVRNYQPCVQRAERYFREW-KSSNGNMSIPIDVTL- 758

  Fly   829 GVVYCSAIQYGTEYEWDFAFERFLKTNVPGEKDLLLNALGCSKEPWLLYRFLRRGISGQHIRKQD 893
             .|:....| .|| .|||.:.::..:....||..:..:|..||:|..|...|.:...|:.|:.|:
Mouse   759 -AVFAVGAQ-NTE-GWDFLYSKYQSSLSSTEKSQIEFSLCTSKDPEKLQWLLDQSFKGEIIKTQE 820

  Fly   894 LFRVFAAVSTTVVGQNIAFDFLRNNWQEI--KTYMGSQMSSIHTLFKFATKGFNSKFQLGEFENF 956
            ...:...:....||..:|:.|||.||.::  |..:||  |||..:....|..|:::.:|.|.:.|
Mouse   821 FPHILTLIGRNPVGYPLAWKFLRENWNKLVQKFELGS--SSIAHMVMGTTDQFSTRARLEEVKGF 883

  Fly   957 VKD--AHWDYDRPVQQIVEHIETSVDWMNKNYKSIVRWLENE 996
            ...  .:....|.|||.:|.||.::.||:||:..|..||:.|
Mouse   884 FSSLKENGSQLRCVQQTIETIEENIRWMDKNFDKIRLWLQKE 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	172/404 (43%)
		M1_APN_2	121..576	CDD:189008	197/486 (41%)
		ERAP1_C	652..974	CDD:288671	96/331 (29%)
Erap1	NP_109636.1	M1_APN-Q_like	50..515	CDD:341064	193/481 (40%)
		Substrate binding. /evidence=ECO:0000250	306..310		3/3 (100%)
		ERAP1_C	586..905	CDD:403137	98/334 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.820