DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and Lvrn

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_083284.1	Gene:	Lvrn / 74574	MGIID:	1921824	Length:	991	Species:	Mus musculus

Alignment Length:	1053	Identity:	320/1053 - (30%)
Similarity:	498/1053 - (47%)	Gaps:	156/1053 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SRPMNAATPTTTTTFSKGGRRYSVSLTTAILLASFFICTLLAVGFIVYNFATCAELEPD------ 83
            |||           ||.|   ..||...|:|||:.....||.:..:...:.:||.::|.
Mouse     2 SRP-----------FSSG---VYVSRGVALLLAALTAVLLLVLVALASLYGSCAHVQPSEQGNSR 52

  Fly    84 -------------------SDEDVVCTSYHLRRLKAGHDDTPKYDRDVRLPHSIRPLKYNITIEP 129
                               :.|..|.||..|     |....| :|. :|||..:.||.|::.:.|
Mouse    53 VKNTSLWPPGGQEWALPTPAQEPTVGTSQDL-----GPPSGP-WDH-LRLPPWLVPLHYDLELWP 110

  Fly   130 QLS------GNFTFAGSVQIRIRVLEDCYNITMHAEELNISR-----------SDASVHRVQNNG 177
            .|.      .|.||.|.|.|.:|.......:.:|:..||..:           .:|:|.|||
Mouse   111 WLQPDKLSPPNLTFTGRVNITVRCTVASSRLLLHSFLLNYKQVEVWGPLAQDTRNATVGRVQ--- 172

  Fly   178 EPEGDGLRIHKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDG-IIEDYLQGFYRSSYEVHNETR 241
                    :.|.:.....||.|::|...|.....|.:...|.| :::..|:|.:.:.|...:|.|
Mouse   173 --------VEKVWFAPDMQFVVLDLGQSLEPGSRYELSFHFSGQVLQVGLEGLFLNLYHDEDELR 229

  Fly   242 WVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSSNDHATMPSYVWD---- 302
            .:.:||.:.|.||..|||||||||||.|.:.:........:||||.:..::...:....|.
Mouse   230 ALVATQMEPTFARHVFPCFDEPALKATFNITVIHHPGYAALSNMPQLGQSERIDVNGSRWTVTTF 294

  Fly   303 HFAESLPMSTYLVAYAISDFTHIS----SGNFAVWARADAIKSA--EYALSVGPRILTFLQDFFN 361
            |....:|  |||||..:.|..|||    .....||||.|.|.|.  ::|.::...|.:||:|.||
Mouse   295 HTTPRMP--TYLVALVVCDLDHISRTERGKEIRVWARKDDIASGYLDFAANITGPIFSFLEDLFN 357

  Fly   362 VTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQWFGNL 426
            :::.|||.|::|||.|.:||||||||:.|.|:::|.:|.......:..:.|::.||:.|||||||
Mouse   358 ISYRLPKTDIVALPIFASGAMENWGLLIFDESSLLLEPEDELTEKRAMILSIIAHEVGHQWFGNL 422

  Fly   427 VTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDALSTSHKISHEVFNPQ 491
            ||.|||::||||||||||.|....:...|:......|....|..:...|....|..:|..|.|..
Mouse   423 VTMSWWNNIWLNEGFASYFELELTNYFYPKVPMNMIFFFTVLHGILGEDHALESRAVSTAVENFT 487

  Fly   492 EISEI---FDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLWHFLTVEAKSS 553
            |.|||   ||..:|.||:.:..|:|.||:..:|...|..||:..:|::|.|||||..:.:.....
Mouse   488 ETSEINRLFDLYTYKKGACMAWMLASFLSPHLFINALKSYLETFSYSNAEQDDLWRHIQMAIGEQ 552

  Fly   554 GLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVYTNTTREDESLL-----WYIP 613
            .:.....:||.|||:||.:.|:|::.|  :.::.|::.|.   .|.:.. |:::||     |.:|
Mouse   553 NVTHLPATVKGIMDSWTHRGGFPIITV--NVSTGVVKQEP---FYLDKV-ENQTLLSHNSTWIVP 611

  Fly   614 ITFTTDSELNFANTRPTTWM-------PRTKLYELENRELSLAKWFIFNVQQTGYYRVNYDLENW 671
            |.:     :.....:|..|:       |..||.:      |.:.|.|.|...|||||||||...|
Mouse   612 IFW-----MKNGIPQPLVWLDKSNMMFPGMKLSD------SDSDWVILNFNVTGYYRVNYDELGW 665

  Fly   672 MAITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAISNF 736
            ..::|.| :.|. :.|...||.||:.|...|.:.:|:..|||::||:|:..|...:.|...:.|.
Mouse   666 KKLSEQL-EKDP-KAIPVINRLQLVSDAFALTKNNYIEIETALDLTKYIAEEDEILVWFEVLLNL 728

  Fly   737 IFIDSMF-VNS-GDYDLLKNYLLKQLKKVYDQVG--FKDSQDESED---ILVKLKRADILSMACH 794
            |..:.:: ||: ..|.|||.||||:...:::...  .:::....:|   .|..|:|  |...||.
Mouse   729 INREVIYDVNNYALYPLLKKYLLKRFNSIWNTYSAIIRENVASLQDNYLSLFSLER--IFETACW 791

  Fly   795 LGHQECIAEASRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQYGTEYEWDFAFERFLKTNVPGE 859
            ||.::|:..:...|:.|  |.:|::..|  |.:...|.|||:..|::.:|||.|..::  |...|
Mouse   792 LGLEDCLQLSRELFKKW--TAHPETAIP--PQIENAVLCSAVALGSDKDWDFLFNLYI--NTTEE 850

  Fly   860 KD-----LLLNALGCSKEPWLLYRFLRRGISGQHIRKQDLFRVFAAVSTTVVGQNIAFDFLRNNW 919
            :|     .|::|:.|||:||:|.||:...|:.......:. .:...|:|:.||:.||.|||.:||
Mouse   851 EDESRRRRLVHAMSCSKDPWILNRFMEYAITAVSSNFSET-NIIVVVATSEVGRYIAKDFLMDNW 914

  Fly   920 QEIKTYMGSQMSSIHTLFKFATKGFNSKFQLGEFENFVKDAHWDYDRPVQQI------------V 972
            ..:....|  |..:..|.....:..::..|:.|.::|......::.|.|.|.            .
Mouse   915 VAVTERYG--MDWLDALVPVLGRTVSTDQQVTELQHFFSTVLEEHQRVVVQAKLQAMKTKNLQNK 977

  Fly   973 EHIETSVDWMNKN 985
            :.|...|:|:.||
Mouse   978 KRIARVVEWLRKN 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	145/422 (34%)
		M1_APN_2	121..576	CDD:189008	166/485 (34%)
		ERAP1_C	652..974	CDD:288671	102/345 (30%)
Lvrn	NP_083284.1	Peptidase_M1	94..504	CDD:279741	145/422 (34%)
		M1_APN_2	102..575	CDD:189008	166/485 (34%)
		Substrate binding. /evidence=ECO:0000250	376..380		3/3 (100%)
		ERAP1_C	646..964	CDD:288671	101/330 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845867
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.650