DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and ERAP2

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_001123612.1	Gene:	ERAP2 / 64167	HGNCID:	29499	Length:	960	Species:	Homo sapiens

Alignment Length:	960	Identity:	313/960 - (32%)
Similarity:	490/960 - (51%)	Gaps:	98/960 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 VCTSYHLRRLKAGHDDTPKYDR----DVRLPHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLE 149
            |.:|||..............:|    ::|||..:.||.|::.:.|.|: :..|..|.:|.:.|..
Human    40 VPSSYHFTEDPGAFPVATNGERFPWQELRLPSVVIPLHYDLFVHPNLT-SLDFVASEKIEVLVSN 103

  Fly   150 DCYNITMHAEELNISRSDASVHRVQNNGEPEGDGLRI-----HKQYLVGAKQFFVIELYDKLLKD 209
            ....|.:|:::|.|:.:...........:| |..|::     |:|        ..:.:.:||...
Human   104 ATQFIILHSKDLEITNATLQSEEDSRYMKP-GKELKVLSYPAHEQ--------IALLVPEKLTPH 159

  Fly   210 VEYVVHLRFDGIIEDYLQGFYRSSYE-VHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHI 273
            ::|.|.:.|...:.|..:|||:|:|. :..|||.:|.|.|:.|.||.||||||||..||||::.|
Human   160 LKYYVAMDFQAKLGDGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKI 224

  Fly   274 ARPRNMTTISNMPIVSSNDHATMPSYVWDHFAESLPMSTYLVAYAISDFTHI----SSG-NFAVW 333
            .|......:||||.|.:.:  .....:.|||..::.||||||||.:.||..:    ||| ..:::
Human   225 RRESRHIALSNMPKVKTIE--LEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIY 287

  Fly   334 ARADAIKSAEYALSVGPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYD 398
            |..|......|||....::|.|.:.:|::.:||.|:|:||:|:|..||||||||||:|||::|:|
Human   288 ASPDKRNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFD 352

  Fly   399 PGVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQF 463
            |..::|::|..|..|:.|||||||||||||..||:||||.||||.|||.:..:|..|| .|.|.:
Human   353 PKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPE-LQFDDY 416

  Fly   464 VVNELQAVFQLDALSTSHKISHEVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKY 528
            .:|....|...|:|::|..||.....|.:|.|:||.:||.||:.|:.|:..||....|::|:.:|
Human   417 FLNVCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQY 481

  Fly   529 LQEMAYNSATQDDLWHFLTVEAKSS-------------------GLLDDSRSVKEIMDTWTLQTG 574
            |::.:|.:|..||||..|:.....|                   ..|.::..|||:|.|||||.|
Human   482 LKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKG 546

  Fly   575 YPVVKVSRHPNSDVIRLEQVRFVYTNTTRED-------ESLLWYIPITFTTDSELNFANTRPTTW 632
            .|::.|.:...|  :||:|.||: ....:||       |..||:||:|::|.|. |..:..  ..
Human   547 IPLLVVKQDGCS--LRLQQERFL-QGVFQEDPEWRALQERYLWHIPLTYSTSSS-NVIHRH--IL 605

  Fly   633 MPRTKLYELENRELSLAKWFIFNVQQTGYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLID 697
            ..:|...:|..:    ..|..|||...|||.|:|:...|..:...|.  .|...:.|.:|..||.
Human   606 KSKTDTLDLPEK----TSWVKFNVDSNGYYIVHYEGHGWDQLITQLN--QNHTLLRPKDRVGLIH 664

  Fly   698 DVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAISNFIFIDSMF-----VNSGDY-DLLKNYL 756
            ||..|.....|:.:.|:::|.||.||...   .|.:....:::|.:     .|..|. :.||.||
Human   665 DVFQLVGAGRLTLDKALDMTYYLQHETSS---PALLEGLSYLESFYHMMDRRNISDISENLKRYL 726

  Fly   757 LKQLKKVYDQVGFKDSQDESEDILVKLKRADILSMACHLGHQECIAEASRHFQNWMQTPNPDSNN 821
            |:..|.|.|    :.|..:...:..::.|:.:|.:||.|.|..||.:|:..|..||::    |..
Human   727 LQYFKPVID----RQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMES----SGK 783

  Fly   822 PIVP-NLRGVVYCSAIQYGTEYEWDFAFERFLKTNVPGEKDLLLNALGCSKEPWLLYRFLRRGIS 885
            ..:| ::..:||....|  |...|::..|::..:....|::.:|.||..||....|.:.:..|:.
Human   784 LNIPTDVLKIVYSVGAQ--TTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGME 846

  Fly   886 GQHIRKQDLFRVFAAVSTTVVGQNIAFDFLRNNWQEI--KTYMGSQMSSIHTLFKFATKGFNSKF 948
            |:.|:.|:|..:..|::....||.:|:||:|.||..:  |..:||.  .|..:....|..|:||.
Human   847 GKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSY--DIRMIISGTTAHFSSKD 909

  Fly   949 QLGEFENF-----VKDAHWDYDRPVQQIVEHIETSVDWMNKNYKSIVRWL 993
            :|.|.:.|     .:.:|.|.   .|.::|.|..::.|:.||..::..||
Human   910 KLQEVKLFFESLEAQGSHLDI---FQTVLETITKNIKWLEKNLPTLRTWL 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	157/402 (39%)
		M1_APN_2	121..576	CDD:189008	182/484 (38%)
		ERAP1_C	652..974	CDD:288671	93/335 (28%)
ERAP2	NP_001123612.1	Peptidase_M1	68..458	CDD:279741	157/402 (39%)
		M1_APN_2	76..548	CDD:189008	182/484 (38%)
		Substrate binding	334..338		3/3 (100%)
		ERAP1_C	621..938	CDD:288671	94/336 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820