DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14516 and erap1a

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	XP_009303348.1	Gene:	erap1a / 564068	ZFINID:	ZDB-GENE-091113-7	Length:	933	Species:	Danio rerio

Alignment Length:	1006	Identity:	320/1006 - (31%)
Similarity:	499/1006 - (49%)	Gaps:	141/1006 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 ILLASFFICTLLAVGFIVYNFATCAELEPDSDEDVVCTSYHLRRLKAGHDDTP-KYDRDVRLPHS 117
            :.||.:|..||:|:        .||          :....|...:.......| .:|: :|||..
Zfish     2 LFLAKYFHFTLVAL--------FCA----------LFAGNHAMTVNKNKTVLPFPWDK-MRLPEI 47

  Fly   118 IRPLKYNITIEPQLSGNFTFAGSVQIRIRVLEDCYNITMHAEELNISRSDASVHRVQNNGEPEGD 182
            ::|..|::.|.|.|: :.||.|.|||:|.|.:|...|.:|::.|.:|
Zfish    48 VKPQHYDLLIHPNLT-SLTFTGEVQIQIEVKQDTRAIILHSKNLQVS------------------ 93

  Fly   183 GLRIHKQYLVGAKQFF--------------VIELYDK--LLKDVEYVVHLRFDGIIEDYLQGFYR 231
                 |..|:|::|..              .|.|:.:  ..:...:||||.|...:.|...|||:
Zfish    94 -----KALLLGSRQHHHHQDLQISEFEANEQIALFSEGFTFEKGSHVVHLEFYANLSDSFHGFYK 153

  Fly   232 SSYEVHN-ETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSSNDHAT 295
            ..|..:: |.|.:|||||:.|.||.|||||||||.|||||:.:.|.....:|||||.:.:.:.|
Zfish   154 GQYTTNSGEVRMLASTQFEPTHARAAFPCFDEPAFKANFTIRVRRESRHISISNMPKLRTVELA- 217

  Fly   296 MPSYVWDHFAESLPMSTYLVAYAISDFTHISSGN-----FAVWARADAIKSAEYALSVGPRILTF 355
             ...:.|.|...:.|||||||:.|.||..||..:     .:|:...:.|..|||||.....:|.|
Zfish   218 -DGILEDQFDTMVKMSTYLVAFIICDFHSISKKSQHGVEISVYTVPEKISQAEYALDTAVTMLDF 281

  Fly   356 LQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAH 420
            ..::|::.:||||.|:.|:|:||:||||||||.|:||:.:|:||..:::::|..:..|:.|||||
Zfish   282 YDEYFDIPYPLPKHDLAAIPDFQSGAMENWGLSTYRESGLLFDPEKSSSSDKLGITKVIAHELAH 346

  Fly   421 QWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDALSTSHKISH 485
            ||||||||..||:|:|||||||.:|||::.:...|| .|::.:.:.:......:|:||:||.:|.
Zfish   347 QWFGNLVTMQWWNDLWLNEGFAKFMEYVSVNITHPE-LQVNDYFLEKCFTALSVDSLSSSHPVST 410

  Fly   486 EVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLWHFLTVEA 550
            .|.||.||||:||.:||.||:.|:.|:..|||..:|:.|:..||::.:|.:.....||..||...
Zfish   411 PVENPAEISEMFDDVSYRKGACILNMLRDFLTPEVFKYGIINYLKKHSYQNTVNSHLWESLTNIC 475

  Fly   551 KSSGL------LD------------------DSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRL 591
            .|.||      ||                  ||..|..||||||||.|:|::.|  ......:.|
Zfish   476 TSDGLDSGRLKLDGFCSKHTAETPASKWFKEDSVDVGAIMDTWTLQEGFPLITV--EVKGQEVTL 538

  Fly   592 EQVRFVYTNTTREDESLLWYIPITFTTD-----SELNFANTRPTTWMPRTKLYELENRELSLAKW 651
            :|.||:....:....|.||.:|:|:.|.     ........|...::|..            .:|
Zfish   539 KQERFLKGAESSNSSSFLWQVPLTYITSGSNAVQRFLLKTERDVFYLPEK------------VEW 591

  Fly   652 FIFNVQQTGYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNL 716
            ..|||...|||.|:|:...|..:.:.|.  .|....:..:||.||.|:..|.....:..:.|:||
Zfish   592 IKFNVDLRGYYIVHYESGGWDCLIKQLR--MNHTVFSSNDRASLIHDIFQLVSIEKVPLDKALNL 654

  Fly   717 TRYLGHELGHVPWKAAISNFIFIDSMFVNSGDYDL---LKNYLLKQLKKVYDQVGFKDSQDESED 778
            :.||..|...:|.....|..:.:..:.......:|   ||::|:|..:.:.|:..:.|:...||.
Zfish   655 SLYLSKESEIMPVTQGFSELVPLYKLMEKRDMQELENQLKSHLVKLFQPLIDRQSWSDNGSVSER 719

  Fly   779 ILVKLKRADILSMACHLGHQECIAEASRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQYGTEYE 843
            :|    |..:|..||...:..|::.|::.|..|.::   |....:..::..|||....:  |:..
Zfish   720 ML----RNYLLLFACVRRYPSCVSTATQLFHKWKES---DGKMWLPTDVSLVVYTEGAR--TDDG 775

  Fly   844 WDFAFERFLKTNVPGEKDLLLNALGCS----KEPWLLYRFLRRGISGQHIRKQDLFRVFAAVSTT 904
            |||..|::.::..|.||.::..||..|    |..||    |.|...|:.::.|||..:..:||..
Zfish   776 WDFLLEKYKRSVSPSEKWMIKAALSYSPLAHKLQWL----LERSSEGEIMKTQDLPSMLISVSKN 836

  Fly   905 VVGQNIAFDFLRNNWQEI--KTYMGSQMSSIHTLFKFATKGFNSKFQLGEFENFVKDAHWDYD-- 965
            ..|..:|:|||::||.::  |..:||  |:|..:....|..:::|..|.|.|.|......|..
Zfish   837 PKGFKLAWDFLKSNWGKLVKKFDLGS--SAISRVVVGVTDQYSTKEMLDEVELFFGSLAQDQGSG 899

  Fly   966 -RPVQQIVEHIETSVDWMNKNYKSIVRWLEN 995
             |.:||.:|.|:.::.||::|...:..||::
Zfish   900 LRSIQQALEKIQQNILWMDRNVPLLKAWLDH 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	163/413 (39%)
		M1_APN_2	121..576	CDD:189008	192/500 (38%)
		ERAP1_C	652..974	CDD:288671	91/333 (27%)
erap1a	XP_009303348.1	Peptidase_M1	43..430	CDD:279741	163/413 (39%)
		M1_APN_2	52..525	CDD:189008	192/499 (38%)
		ERAP1_C	592..909	CDD:288671	91/333 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820