DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14516 and si:ch211-106j24.1

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	XP_021327531.1	Gene:	si:ch211-106j24.1 / 555478	ZFINID:	ZDB-GENE-130530-595	Length:	960	Species:	Danio rerio

Alignment Length:	1008	Identity:	353/1008 - (35%)
Similarity:	537/1008 - (53%)	Gaps:	103/1008 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GRRYSVS---LTTAILLASFFICTLLAVGFIVYN-----------FATCAELEPDSDEDVVCTSY 93
            |:.|.:|   .|.|::||:..:.|::|:. :|||           .||.:.:.|..
Zfish     2 GKGYYISKHLATAAMILAAIALVTIIALS-VVYNREKSKNTAKLTNATTSAVPPTP--------- 56

  Fly    94 HLRRLKAGHDDTPKYDRDVRLPHSIRPLKYNITIEPQL----SGNFTFAGSVQIRIRVLEDCYNI 154
                 |..::...||    |||.::.|..||||:.||:    :|.:.|.|...:....::....|
Zfish    57 -----KPSNEPWDKY----RLPDTLSPQYYNITLWPQMVMDANGMYIFTGISDVMFTCVKKTDLI 112

  Fly   155 TMHAEELNISRSDASVHRVQNNGEPEGDGL------RIHKQYLVGAKQFFVIELYDKLLKDVEYV 213
            .:|:.:||::        :.|....:..|:      .|...:|....|:.||:|..||.....|.
Zfish   113 LIHSNKLNLT--------LFNGRHAKLTGMSGVTAPAIKSTWLQTQTQYLVIQLKGKLNPGKSYW 169

  Fly   214 VHLRFDGIIEDYLQGFYRSSYEVHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRN 278
            :|..|.|.:.|.|:|||||.|....|.:.:|.||.|||.||:||||||||.:||.|.:.:...|.
Zfish   170 LHTEFTGELADDLEGFYRSEYMEDGEKKIIAITQMQATYARKAFPCFDEPGMKAVFNIILIHDRG 234

  Fly   279 MTTISNMPIVSSNDHA--TMPSYVWDHFAESLPMSTYLVAYAISDFTHISSGNFA-----VWARA 336
            ||.:||...:.:.|..  .|| .....|..:..|||||||:.:|||::|::.:.|     :|||.
Zfish   235 MTALSNSQEIRTEDVIIDEMP-VTRTTFEPTARMSTYLVAFVVSDFSYINNEDKAGVLVRIWARK 298

  Fly   337 DAIK--SAEYALSVGPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDP 399
            .||.  ..:||||:...||.|.:.::|.::||.|.|.:|||:|.:||||||||:|:||||:||||
Zfish   299 KAIDDGQGDYALSITQPILEFFESYYNTSYPLSKSDQVALPDFNSGAMENWGLVTYRETALLYDP 363

  Fly   400 GVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFV 464
            ..:...||||:|:||.|||||.|||||||..||:|:|||||||||:|||.||...|.|...||.:
Zfish   364 QTSANGNKQRIATVVSHELAHMWFGNLVTLKWWNDLWLNEGFASYVEYLGADHAEPTWNIKDQII 428

  Fly   465 VNELQAVFQLDALSTSHKIS---HEVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLS 526
            :.::|..|.:|:|::||.:|   .||..|.||||:|..|||:||:.:::|::.|||.|:|.:|||
Zfish   429 LYDMQRAFAVDSLTSSHPLSRKEEEVNTPAEISEMFSTISYSKGAAVLKMLSEFLTEPVFAKGLS 493

  Fly   527 KYLQEMAYNSATQDDLWHFLTVEAKSSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRL 591
            .||::.|:.|:...|||..|......:..:...||:.|||..|.||.|:||:.:.....:    :
Zfish   494 NYLKQFAFGSSVHSDLWDHLQKSLDQAPGMKLPRSIHEIMSRWILQMGFPVITIDTRTGN----V 554

  Fly   592 EQVRFVYTN---TTREDE-SLLWYIPITFTTDSELNFANTRPTTWMPRTKLYELENRELSLAKWF 652
            .|..|:...   ..|:.| :..|::||.:....::     :...|:.:..... :..::|..:|.
Zfish   555 SQKHFLVEKDAVVERKSEFNYEWFVPIKWMKKGQV-----QDQMWLLQKSAIH-KPMKVSKGEWV 613

  Fly   653 IFNVQQTGYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLT 717
            :.|.:.:||:|||||..||..:...|  ..|.:.|...||||::||..||||.|.::...|:..|
Zfish   614 LANHKVSGYFRVNYDHGNWERLLSQL--ETNHQTIPVVNRAQILDDAFNLARASIINITLALRTT 676

  Fly   718 RYLGHELGHVPWKAAISNFIFIDSMFVNSGDYDLLKNYLLKQLKKVYDQVGFKDSQ--------- 773
            :||..|..::||:||:.:..:...:|..:..|..|:.||.||:|.:::..|...|.
Zfish   677 KYLVREREYIPWEAALRSLNYFFQLFDRNEVYGALQAYLKKQVKPLFEHFGTISSNWTKVPNGHT 741

  Fly   774 DESEDILVKLKRADILSMACHLGHQECIAEASRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQY 838
            |:...|:.       ||:||..|.:.|.......|:.|||.|..   |||.||||..|||:||..
Zfish   742 DQFTQIIA-------LSLACGTGVEGCREITKSWFKKWMQNPRV---NPIHPNLRSTVYCNAIAA 796

  Fly   839 GTEYEWDFAFERFLKTNVPGEKDLLLNALGCSKEPWLLYRFLRRGISGQHIRKQDLFRVFAAVST 903
            |...||:|.::.|.|..|..|...|..||.|:|.||||.|:|...|:.:.|||||.......:::
Zfish   797 GGADEWNFGWQMFQKATVAAEAVKLRAALACTKVPWLLNRYLEYSINPEKIRKQDATSTIGYIAS 861

  Fly   904 TVVGQNIAFDFLRNNWQEIKTYMGSQMSSIHTLFKFATKGFNSKFQLGEFENFVKD-AHWDY--- 964
            .|:||.:|:||:|.||.......|:...:...|....|..|.:.|:|.:.:.|.|| |...:
Zfish   862 NVIGQPLAWDFVRANWDYFFKVYGTGSFTFSRLISDITSKFCTPFELSQLKRFQKDNAETGFGSG 926

  Fly   965 DRPVQQIVEHIETSVDWMNKNYKSIVRWLENEA 997
            .:.:||.:|.....:.|:.:|.:.:::|..:|:
Zfish   927 TQALQQAIERTTAKIKWLAENKEPVLQWFISES 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	176/413 (43%)
		M1_APN_2	121..576	CDD:189008	200/476 (42%)
		ERAP1_C	652..974	CDD:288671	114/334 (34%)
si:ch211-106j24.1	XP_021327531.1	M1_APN_2	77..543	CDD:189008	200/474 (42%)
si:ch211-106j24.1	XP_021327531.1	PepN	170..943	CDD:223385	303/795 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	259	1.000	Domainoid score	I1947
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68163
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		mtm6446
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3793
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.950