DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and si:ch211-276a23.5

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	XP_001922987.2	Gene:	si:ch211-276a23.5 / 555317	ZFINID:	ZDB-GENE-141215-4	Length:	956	Species:	Danio rerio

Alignment Length:	988	Identity:	337/988 - (34%)
Similarity:	524/988 - (53%)	Gaps:	75/988 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GRRYSVSLTTAILLASFFICTLLAV-GF-IVYNFATCAELEPDSDEDVV-CTSYHLRRLKAGHDD 104
            |:.:.:|...|.:|.:..:.:||.: |. ::|     |:.:..::|::| .|...|.........
Zfish     2 GKGFYISKPLAFVLLALAVGSLLTILGLSLIY-----AQEKRRNEENMVNNTVTTLAPYSTSIPS 61

  Fly   105 TPKYDRDVRLPHSIRPLKYNITIEPQLS----GNFTFAGSVQIRIRVLEDCYNITMHAEELNISR 165
            ...:|: .|||.::.|..||||:.|:|:    |.:.|.|...:....:::...|.:|:..||.|.
Zfish    62 NEPWDK-YRLPDTLLPEYYNITLWPRLTKDDLGMYIFTGKSGVAFLCVKETDLILIHSSNLNYSL 125

  Fly   166 SDASVHRVQNNGEPEGDGLR---IHKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQ 227
            : |..|..:..|.   .|.|   |.|.:.....:|.||:|.:.|.....|.::..|.|.:.|.|.
Zfish   126 T-AEKHHAELMGL---GGTRAPVILKTWFQDQTEFMVIQLRENLQVGKSYWLYTEFQGELADDLG 186

  Fly   228 GFYRSSYEVHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISN-MPIVSSN 291
            |||||.|..:...:.||:||.|.|.||.||||||||::||.|.|.:..|.....::| |...:.|
Zfish   187 GFYRSEYVENGVEKVVATTQMQPTAARTAFPCFDEPSMKAVFHLTLIHPPGTVALANGMETGTEN 251

  Fly   292 DHATMPSYVWDHFAESLPMSTYLVAYAISDFTHISSGNFA------VWARADAIKSAE--YALSV 348
            ........:...|..:..|||||:|:.||:|..|.|...|      :|.|.:||::.|  |||:|
Zfish   252 ITIENQQVLQTRFEPTEKMSTYLLAFVISEFPSIQSPLGANKILVRIWGRREAIENGEGDYALNV 316

  Fly   349 GPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASV 413
            ...:|.:|:.::|.|:||.|.|.||||:|.|||||||||:|:|||.:.|:|.|::..:|:.|.:|
Zfish   317 TFPVLKYLESYYNTTYPLSKSDQIALPDFSAGAMENWGLVTYRETFLFYEPKVSSHEDKEGVITV 381

  Fly   414 VGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDALS 478
            :.|||||.|||||||..||:|:|||||||||:.||.||...|.|...:..|:.::...|.:|||.
Zfish   382 ISHELAHMWFGNLVTMRWWNDLWLNEGFASYVSYLAADYAEPTWNIKELMVLQQVYRAFTVDALV 446

  Fly   479 TSHKISHE---VFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQD 540
            :||.:|..   |..||:|.|:||.::|:||:.::||::.||:..:|.:||..||||.||::....
Zfish   447 SSHPLSSREDAVNTPQQIEELFDAVTYSKGAAVLRMLSEFLSESVFAKGLHNYLQEHAYSNTVYT 511

  Fly   541 DLWHFLTVEAKSSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVY----TNT 601
            |||..|...|.|.|.:....|::|||:.|.||.|:|||.:..|..|    :.|..|:.    ...
Zfish   512 DLWKKLQEVADSDGNVHLPASIEEIMNRWILQAGFPVVTIDTHTGS----ISQQHFLIDPEAVVN 572

  Fly   602 TREDESLLWYIPITFTTDSELNFANTRPTTWMPRTKLYELENRELSLAKWFIFNVQQTGYYRVNY 666
            ...|.:..|::|||:..    |..|......:.::..|||...|   ..|.:.|:..||||||||
Zfish   573 KPSDYNYEWFVPITWMK----NGRNMGQHWLLNKSTSYELMKTE---TNWILANLNVTGYYRVNY 630

  Fly   667 DLENWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKA 731
            |.:||..:.:.|  ..:.:.|...||.|:|||...|||...|:...|:..|:||.:|..::||::
Zfish   631 DSQNWERLIKQL--TSDHQAIPVLNRGQIIDDAFTLARAKILNITMALRTTQYLSNEKEYIPWES 693

  Fly   732 AISNFIFIDSMFVNSGDYDLLKNYLLKQLKKV--YDQVGFKDSQDESEDILVKLKRADILSMACH 794
            ||.|..:...||..:.....|:.||.::::.:  |.:|...:...:....:.:..:.:.::|||.
Zfish   694 AIRNLEYFFLMFDRTEVRGPLEAYLRRKVEPLFHYFKVITSNWTRKPTRHMDQYNQLNAITMACK 758

  Fly   795 LGHQECIAEASRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQYGTEYEWDFAFERFLKTNVPGE 859
            ...:.|....|..::.||:.||.   ||:..:|:.||||:||..|...||||.:..|..:.|..|
Zfish   759 TRVKACSELTSMWYRQWMKDPNV---NPVPSDLKTVVYCNAIAAGGVEEWDFGWAMFKNSTVAAE 820

  Fly   860 KDLLLNALGCSKEPWLLYRFLRRGISGQHIRKQDLFRVFAAVSTTVVGQNIAFDFLRNNWQEIKT 924
            .:.|:..|.|:||||||.|:|...|....|||||:......:::.|:||.:|:||.|..||.:.|
Zfish   821 AEKLMYGLSCTKEPWLLNRYLHYAIDPNLIRKQDVTYPIVYIASNVIGQPLAWDFFRAKWQLMTT 885

  Fly   925 YMGSQMSSIHTLFKFATKGFNSKFQLGEFENFVKD---------AHWDYDRPVQQIVEHIETSVD 980
                   ....|.....|.|:::|||.:.:.|.::         .|     .::|.:|..:.:|.
Zfish   886 -------EFRVLILGIVKTFSTEFQLQQLQRFQEEVAESGVSLGTH-----AIEQAIEQTKANVK 938

  Fly   981 WMNKNYKSIVRWL 993
            |:::|...::.||
Zfish   939 WVSENKVQVMDWL 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	165/410 (40%)
		M1_APN_2	121..576	CDD:189008	191/473 (40%)
		ERAP1_C	652..974	CDD:288671	103/332 (31%)
si:ch211-276a23.5	XP_001922987.2	M1_APN_2	79..547	CDD:189008	191/471 (41%)
si:ch211-276a23.5	XP_001922987.2	ERAP1_C	615..935	CDD:314669	105/336 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595650
Domainoid	1	1.000	259	1.000	Domainoid score	I1947
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68163
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		mtm6446
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.750