DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14516 and ERAP1

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	XP_005272072.1	Gene:	ERAP1 / 51752	HGNCID:	18173	Length:	951	Species:	Homo sapiens

Alignment Length:	994	Identity:	326/994 - (32%)
Similarity:	514/994 - (51%)	Gaps:	110/994 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LTTAILLASFFICTLLAVGFIVYNFATCAELEPDSDEDVVCTSYHLRRLKAGHDDTPKYDRDVRL 114
            |..::...||.:.:|||: ..|...:.|...|......               |.||.....:||
Human     6 LKWSLATMSFLLSSLLAL-LTVSTPSWCQSTEASPKRS---------------DGTPFPWNKIRL 54

  Fly   115 PHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLEDCYNITMHAEELNISRSDASVHRVQNNGEP 179
            |..:.|:.|::.|...|: ..||.|:.::.|...:....|.:|:..|.|||:...
Human    55 PEYVIPVHYDLLIHANLT-TLTFWGTTKVEITASQPTSTIILHSHHLQISRATLR---------- 108

  Fly   180 EGDGLRIHK---QYLVGAKQFFVIELY-DKLLKDVEYVVHLRFDGIIEDYLQGFYRSSYEV-HNE 239
            :|.|.|:.:   |.|...:|..:..|. :.||..:.|.|.:.:.|.:.:...|||:|:|.. ..|
Human   109 KGAGERLSEEPLQVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGE 173

  Fly   240 TRWVASTQFQATDARRAFPCFDEPALKANFTLHIAR-PRNMTTISNMPIVSSNDHATMPSYVWDH 303
            .|.:|||||:.|.||.|||||||||.||:|::.|.| ||:: .|||||:|.|...|  ...:.||
Human   174 LRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREPRHL-AISNMPLVKSVTVA--EGLIEDH 235

  Fly   304 FAESLPMSTYLVAYAISDFTHIS----SG-NFAVWARADAIKSAEYALSVGPRILTFLQDFFNVT 363
            |..::.|||||||:.||||..:|    || ..:|:|..|.|..|:|||.....:|.|.:|:|::.
Human   236 FDVTVKMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIP 300

  Fly   364 FPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQWFGNLVT 428
            :||||.|:.|:|:||:||||||||.|:||:|:|:|...::|::|..:...|.|||||||||||||
Human   301 YPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAHQWFGNLVT 365

  Fly   429 PSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDALSTSHKISHEVFNPQEI 493
            ..||:|:|||||||.:||:::.....||.|..|.|......|: ::|||::||.:|..|.||.:|
Human   366 MEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYFFGKCFDAM-EVDALNSSHPVSTPVENPAQI 429

  Fly   494 SEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLWHFLTVEAKSSGL--L 556
            .|:||.:||.||:.|:.|:..:|:...|:.|:.:|||:.:|.:...:|||..:.....:.|:  :
Human   430 REMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASICPTDGVKGM 494

  Fly   557 DD--SRS---------------VKEIMDTWTLQTGYPVVKVS-RHPNSDVIRLEQVRFVYTNTTR 603
            |.  |||               ||.:|:|||||.|:|::.:: |..|   :.::|..::..:...
Human   495 DGFCSRSQHSSSSSHWHQEGVDVKTMMNTWTLQKGFPLITITVRGRN---VHMKQEHYMKGSDGA 556

  Fly   604 EDESLLWYIPITFTTDSELNFANTRPTTWMPRTKLYELENRELSL---AKWFIFNVQQTGYYRVN 665
            .|...||::|:||.|..          :.|....|.:.:...|.|   .:|..|||...|||.|:
Human   557 PDTGYLWHVPLTFITSK----------SDMVHRFLLKTKTDVLILPEEVEWIKFNVGMNGYYIVH 611

  Fly   666 YDLENWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWK 730
            |:.:.|.::|..|.....  .::..:||.||::...|.....||.|.|::|:.||.||...:|..
Human   612 YEDDGWDSLTGLLKGTHT--AVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPVF 674

  Fly   731 AAISNFI----FIDSMFVNSGDYDLLKNYLLKQLKKVYDQVGFKDSQDESEDILVKLKRADILSM 791
            ..::..|    .::...:|..:.. .|.:|::.|:.:.|:..:.|....||.:|    |:.:|.:
Human   675 QGLNELIPMYKLMEKRDMNEVETQ-FKAFLIRLLRDLIDKQTWTDEGSVSERML----RSQLLLL 734

  Fly   792 ACHLGHQECIAEASRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQYGTEYEWDFAFERFLKTNV 856
            ||...:|.|:..|..:|:.|.:: |.:.:.|:...|  .|:....| .|| .|||.:.::..:..
Human   735 ACVHNYQPCVQRAEGYFRKWKES-NGNLSLPVDVTL--AVFAVGAQ-STE-GWDFLYSKYQFSLS 794

  Fly   857 PGEKDLLLNALGC-----SKEPWLLYRFLRRGISGQHIRKQDLFRVFAAVSTTVVGQNIAFDFLR 916
            ..||..:..|| |     .|..||    |.....|..|:.|:..::...:....||..:|:.|||
Human   795 STEKSQIEFAL-CRTQNKEKLQWL----LDESFKGDKIKTQEFPQILTLIGRNPVGYPLAWQFLR 854

  Fly   917 NNWQEI--KTYMGSQMSSIHTLFKFATKGFNSKFQLGEFENFVKD--AHWDYDRPVQQIVEHIET 977
            .||.::  |..:||  |||..:....|..|:::.:|.|.:.|...  .:....|.|||.:|.||.
Human   855 KNWNKLVQKFELGS--SSIAHMVMGTTNQFSTRTRLEEVKGFFSSLKENGSQLRCVQQTIETIEE 917

  Fly   978 SVDWMNKNYKSIVRWLENE 996
            ::.||:||:..|..||::|
Human   918 NIGWMDKNFDKIRVWLQSE 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	169/402 (42%)
		M1_APN_2	121..576	CDD:189008	193/484 (40%)
		ERAP1_C	652..974	CDD:288671	90/334 (27%)
ERAP1	XP_005272072.1	M1_APN_2	61..531	CDD:189008	193/484 (40%)
ERAP1	XP_005272072.1	ERAP1_C	597..916	CDD:314669	92/337 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820