DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and Lvrn

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	XP_038953134.1	Gene:	Lvrn / 502160	RGDID:	1562779	Length:	993	Species:	Rattus norvegicus

Alignment Length:	970	Identity:	299/970 - (30%)
Similarity:	471/970 - (48%)	Gaps:	127/970 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 FSKGGRRYSVSLTTAILLASFFICTLLAVGFIVYNFATCAELE----------------PDSDED 87
            ||.|   ..||...|:|||......|||:..:...:.:||.::                |...|.
  Rat     5 FSSG---IYVSRGVALLLAGLTAVLLLALVVLAALYGSCAHVQSSELDSHLVKDTSLSPPGGQEW 66

  Fly    88 VVCTSYHLRRLKAGHDDTP---KYDRDVRLPHSIRPLKYNITIEPQL------SGNFTFAGSVQI 143
            ...|..|...:....|..|   .:|. :|||..:.||.|::.:.|:|      :.:.||.|.|.|
  Rat    67 TQPTPAHESTVGTSQDWRPPSGPWDH-LRLPPWLVPLHYDLELWPRLQPDNLSTPSLTFTGRVNI 130

  Fly   144 RIRVLEDCYNITMHAEELNISR-----------SDASVHRVQNNGEPEGDGLRIHKQYLVGAKQF 197
            .:|.......:.:|:..||..:           .:|:|.||.           :...:.....|:
  Rat   131 TVRCTVATSTLLLHSFFLNYKQVEVWGPLAPDTRNATVGRVP-----------LENVWFALDMQY 184

  Fly   198 FVIELYDKLLKDVEYVVHLRFDG-IIEDYLQGFYRSSYEVHNETRWVASTQFQATDARRAFPCFD 261
            .|::|...|.....|.::..|.| ::::..:|.:.:.|...::.|.:.:||.:.|.||..|||||
  Rat   185 VVLDLGQSLDPGSSYELNFDFSGQVLQEGSEGLFLNLYTDEDQLRALIATQMEPTFARHVFPCFD 249

  Fly   262 EPALKANFTLHIARPRNMTTISNMPIVSSNDHATMPSYVW--DHFAESLPMSTYLVAYAISDFTH 324
            ||||||.|.:.|........:||||.:..:....:....|  ..|..:..|.|||||..|.||.:
  Rat   250 EPALKATFNITIIHHPGYVALSNMPQLGQSHRIDVNGSRWTVTSFHTTPRMPTYLVALVICDFDY 314

  Fly   325 IS----SGNFAVWARADAIKSA--EYALS-VGPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAM 382
            :|    .....||||.|.|...  ::|.: .|| :.:||:|.||:::||||.|:||||.|..|||
  Rat   315 VSRTERGKEIRVWARKDDIADGYLDFAANHTGP-VFSFLEDLFNISYPLPKTDIIALPTFVNGAM 378

  Fly   383 ENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEY 447
            |||||:.| :.::|.:........:..:.|::.||:.|||||||||.|||::||||||||||.|.
  Rat   379 ENWGLMIF-DASLLLELDDDLPEKRAMILSILSHEVGHQWFGNLVTMSWWNNIWLNEGFASYFEV 442

  Fly   448 LTADAVAPEWKQLDQFVVNELQAVFQLDALSTSHKISHEVFN---PQEISEIFDRISYAKGSTII 509
            ...:...|:..:...|.:..|..:.:.|....|..:|..|.|   .:||:.:||..:|.||:.:.
  Rat   443 GLTNYFYPKVPRNMIFFLTVLHDILEDDHSLESRAVSTPVENFTETREINRLFDIYTYKKGACMA 507

  Fly   510 RMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLWHFLTVEAKSSGLLDDSRSVKEIMDTWTLQTG 574
            .|:|.||:..:|...|..||:..:|::|.|||||..:.:......::....:||.|||:||.|:|
  Rat   508 WMLAGFLSQHLFINALKSYLETFSYSNAEQDDLWRHIQMAIDEQSIIHLPATVKRIMDSWTHQSG 572

  Fly   575 YPVVKVSRHPNSDVIR-----LEQVRFVYTNTTREDESLL----WYIPITFTTDSELNFANTRPT 630
            :||:.:  :.::.|::     ||:|         |:::||    |.:||.:     :....|:|.
  Rat   573 FPVITL--NASTGVVKQEPFYLERV---------ENQTLLSHNTWIVPIFW-----MKNGITQPL 621

  Fly   631 TWM-------PRTKLYELENRELSLAKWFIFNVQQTGYYRVNYDLENWMAITEHLMDVDNFEDIA 688
            .|:       |..||.:      |.:.|.|.|...|||||||||...|..:.:.| :.|. :.|.
  Rat   622 VWLDKSSMIFPGMKLSD------SDSDWVILNFNVTGYYRVNYDKLGWKKLNQQL-EKDP-KAIP 678

  Fly   689 PANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAISNFIFIDSMF--VNSGDYDL 751
            ..||.||:.|...|::.:|:..|||::||:|:..|...:.|...:.|.|..:.::  .|...|.|
  Rat   679 VINRLQLVSDAFALSKNNYIEIETALDLTKYIAKEDEILVWFEVLVNLINREVVYDVKNYYLYPL 743

  Fly   752 LKNYLLKQLKK---VYDQVGFKDSQDESEDILVKLKRADILSMACHLGHQECIAEASRHFQNWMQ 813
            ||.|.||:|..   :|..:..::.....::.|..|........||.||.::|:..:...|:.||.
  Rat   744 LKKYFLKRLNSIWTIYSAIIRENMASLQDNFLSLLPLKKFFETACWLGLEDCLQLSRELFRKWMA 808

  Fly   814 TPNPDSNNPIVPNLRGVVYCSAIQYGTEYEWDFAFERFL-KTNVPGEKDL--LLNALGCSKEPWL 875
            .|    ...|.|.:..||.|:||..|:..:|||.|..:: ||.  .::||  |::|:||||:|..
  Rat   809 HP----ETAIPPQIEKVVLCNAIALGSNKDWDFLFNLYINKTE--EQEDLFHLVHAMGCSKDPRT 867

  Fly   876 LYRFLRRGIS--GQHIRKQDLFRVFAAVSTTVVGQNIAFDFLRNNWQEIKTYMGSQMSSI 933
            |.||:...|:  .....:.:|..|   |:.:.||:.:|.|||.|||  :..|....:|.:
  Rat   868 LNRFMEYDITVFPSRFNETNLIEV---VAESEVGRYVAKDFLINNW--VAVYESPSLSPL 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	138/421 (33%)
		M1_APN_2	121..576	CDD:189008	160/484 (33%)
		ERAP1_C	652..974	CDD:288671	94/292 (32%)
Lvrn	XP_038953134.1	M1_APN-Q_like	102..569	CDD:341064	157/479 (33%)
Lvrn	XP_038953134.1	ERAP1_C	643..915	CDD:403137	93/284 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349297
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850