DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14516 and rnpep

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_001002741.1	Gene:	rnpep / 437014	ZFINID:	ZDB-GENE-040718-241	Length:	626	Species:	Danio rerio

Alignment Length:	750	Identity:	157/750 - (20%)
Similarity:	261/750 - (34%)	Gaps:	206/750 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 LEPDSDEDVVCTSYHLRRLKAGHDDTPKYDRDVRLPHSIRPLKYNITIEPQLSGNFTFAGSVQIR 144
            |..|..|| |.||...|:.|..|     :..|:::....:.:....|||.|...:  ....:|:.
Zfish     9 LYSDKAED-VATSSSFRQFKIEH-----FHLDLKVDFLQKSISGTETIELQCIQD--SQSELQLD 65

  Fly   145 IRVLEDCYNITMHAEELNISRSDASVHRVQNNGEPEGDGLRIHKQYLVGAKQFFVIELYDKLLKD 209
            |......:.||:.....:.:|::.......:.|          ...||.....|..:  |||...
Zfish    66 IHPSLSVHEITLSQNARDWTRTEFLTQDFTSYG----------TTLLVKFPTAFSSD--DKLQLA 118

  Fly   210 VEYVVHLRFDGIIEDYLQGFYRSSYEVHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIA 274
            :.|..   .||....:|:     ..:...:.:....||.||...|..|||||.||:|:.::..:.
Zfish   119 IRYTA---TDGPGVCWLE-----PEQTAGKLKPYVFTQGQAVLNRSCFPCFDTPAVKSTYSAAVQ 175

  Fly   275 RPRNMTTISNMPIVSSNDHATMPSYVWDH--------FAESLPMSTYLVAYAISDFTHISSG-NF 330
            .|...|             |.|.:..|:.        |....|:..||||.|:.|......| ..
Zfish   176 VPDGFT-------------AVMSANKWEQRKADGAFLFTMEHPIPAYLVALAVGDLQSAEVGPRT 227

  Fly   331 AVWARADAIKSA--EY------ALSVGPRIL-TFLQDFFNVTFPLPKIDMIALPEFQAGAMENWG 386
            .||.....:::|  ||      .||||.::. .::...::|.| :|       |.|..|.||| .
Zfish   228 RVWTEPCLLQAAKQEYDNVIEDFLSVGEKLFGPYVWGRYDVLF-MP-------PSFPFGGMEN-P 283

  Fly   387 LITFRETAMLYDPGVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASY------- 444
            .:||....:|       |.::. :|.|:.||:.|.|||||||.:.|.|.||||||..|
Zfish   284 CLTFVTPCLL-------AGDRS-LADVIVHEICHSWFGNLVTNATWGDFWLNEGFTMYAQRRVCR 340

  Fly   445 ---------MEYLTADAVAPEWKQLDQFVVNELQAVFQLDALSTSH---KISHEVFNPQEISEIF 497
                     :|..|..|:..:                .:|.....|   |:..::....:..:.:
Zfish   341 ELYGEAYTCLEAATGKALLRQ----------------HMDNTGEDHPLNKLRVKIEPGVDPDDTY 389

  Fly   498 DRISYAKGSTIIRMMAHFLTNPI-FRRGLSKYLQEMAYNSATQDDLWHFLT---VEAKSSGLLDD 558
            :...|.||...:..:||...:.. |...|..|:::..:.|...:|...|..   .|.|
Zfish   390 NETPYEKGFCFVSYLAHLTGDQSRFDTFLKAYVEKFKFRSVLAEDALEFYLEYFPELK------- 447

  Fly   559 SRSVKEI----MDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVYTNTTREDESLLWYIPITFTTD 619
            .|:|.:|    .|:|....|:|.                                 |:|
Zfish   448 ERNVHKIEGLDFDSWLNVPGWPP---------------------------------YVP------ 473

  Fly   620 SELNFANTRPTTWMPRTKLYELENRELSLAKWFIFNVQQTGYYRVNYDLENWMAI-TEHLMD--- 680
             :|:...|.            ::..||...||...|:......:.  ||::|... |.:.:|
Zfish   474 -DLSAGQTL------------MKPAELLAEKWLSHNLDLESICKT--DLKSWKTYQTVYFLDRIL 523

  Fly   681 -------------VDNFEDIAPANRAQL-IDDVMNLARGSYL-SYETAMNLTRYLGHELGHVPWK 730
                         .:.:..|..:|.|:| :.....:|:..|. .::...:.....|.:...:|..
Zfish   524 EKSPLPDGNLKKLEECYSQIIKSNNAELKVRWAQIVAKNQYSPGFQHIRDFLSSQGKQKYTLPVY 588

  Fly   731 AAISN------FIFIDSMFVNSGDYDL-LKNYLLK 758
            .|:.|      .:.|:.....||...: ::||:.|
Zfish   589 RALWNGSEETKALAIEMFSATSGQLHVNVRNYVKK 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	97/428 (23%)
		M1_APN_2	121..576	CDD:189008	115/499 (23%)
		ERAP1_C	652..974	CDD:288671	21/132 (16%)
rnpep	NP_001002741.1	leuko_A4_hydro	16..623	CDD:274120	153/741 (21%)
		M1_LTA4H	16..464	CDD:189006	122/528 (23%)
		Leuk-A4-hydro_C	484..624	CDD:286244	25/141 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810