DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and CG42335

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster

Alignment Length:	993	Identity:	258/993 - (25%)
Similarity:	448/993 - (45%)	Gaps:	147/993 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LTTAILLASFFICTLLAVGFIVYNFATCAELEPDSDEDVVCTSYHLRRLKAGHDDTPKYDRDVRL 114
            ::::|..|.:.:|:||   ..|.|.|                                   |.||
  Fly     1 MSSSIFRAFWLLCSLL---ICVTNAA-----------------------------------DYRL 27

  Fly   115 PHSIRPLKYNITI-------EPQLSGNFTFAGSVQIRIRVLE--DCYNITMHAEELNISRS---D 167
            ..|:.|..||:||       ||.:     |.|.|.|.:||:.  :...|.:||:.|:|:..   |
  Fly    28 EGSVVPSHYNLTIGVLRNSVEPTI-----FDGEVSITLRVVGTLEVQQIILHADTLDITECWLLD 87

  Fly   168 ASVHRVQNNGEPEGDGLRIHKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQGFYRS 232
            |:..:|        :.:.|.:.....|.|...:.|.:.......|.:..::.|.|...:.||:.:
  Fly    88 AAGAQV--------EAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSA 144

  Fly   233 SYEVH--NETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSSNDHAT 295
            ||...  |.|||:|.||.|..:||...||||||||||.|.|.|.||....:|:|..:..:.  |.
  Fly   145 SYVERDTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETK--AL 207

  Fly   296 MPSYVWDHFAESLPMSTYLVAYAISDFTHISSGN---FAVWARADAIKSAEYALSVGPRILTFLQ 357
            ......|||.|:..|||||:|:.:::::  :.||   |||..|.:...:.|::..||.::::...
  Fly   208 SQDRFVDHFKETPVMSTYLLAFMVANYS--ARGNESEFAVLTRPEFYDNTEFSYHVGQQVVSAYG 270

  Fly   358 DFFNVTFPLPKIDMI---ALPEFQAGAMENWGLITFRETAMLYDPGVATA-NNKQRVASVVGHEL 418
            :.|...:.....|::   :.|.|....|||||||.:.:..::.:||.:.. ::|:....::.||.
  Fly   271 ELFQSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHET 335

  Fly   419 AHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDALSTSHKI 483
            :|.|||:.||.||||..||||.||.|.||..|..:.|::...:||||.::|.:|..||.:.:..:
  Fly   336 SHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQPM 400

  Fly   484 S---HEVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLWHF 545
            :   .|:..|.:|:..|..|:||||:.|:||..:.:....|...:..|||:....:....:|::.
  Fly   401 TSPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYH 465

  Fly   546 LTVEAKSSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVYTNTTREDESLLW 610
            |......:..:|    :.:.:..:|.|.|||::.|.....:.|:.:||.||:.......:.:|.:
  Fly   466 LFEHWPKNQDVD----LVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLNKDDGSNATLKY 526

  Fly   611 YIPITFTTDSELNFANTRPTTWMPRTKLYELENRELSLAKWFIFNVQQTGYYRVNYD--LENWMA 673
            .:||||||:.|.:|.|..|..::.:| :..|.....|...|.:||::|:.|.||.||  |...:.
  Fly   527 TVPITFTTNLERDFYNLTPYKYLHKT-VNVLWLDFTSPIDWILFNLRQSNYQRVFYDDTLREGLL 590

  Fly   674 ITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAISNFIF 738
            :.   :...|...|...||||:|||:.|.|:..|:.|........||..|:.:|||.|...|...
  Fly   591 LA---ISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWYAVYENLNT 652

  Fly   739 IDSMFVNSGDYDLLKNYLLKQLKKVYDQVGFK-DSQDESEDILVKLKRADILSMACHLGHQECIA 802
            :..........| .:.||......|::::|.. ::||...|:   ..|..::...|......|..
  Fly   653 VAKRLTPEQLPD-FRIYLSSITAAVFEKLGVGWNAQDTPLDV---ANRNKLIKWLCRYQASNCRP 713

  Fly   803 EASRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQYGTEY-EWDFAFERFLKTNVPGEKDLLLNA 866
            :.:..|....:.|:||        .|...||:|  .|.:| .:...:.::...|...||::|..|
  Fly   714 KVNVQFVTGHEVPSPD--------YRETFYCAA--SGADYNSYTMLWGQYYLENRTSEKNMLWAA 768

  Fly   867 LGCSKEPWLLYRFL-----------RRGISGQHIRKQDLFR-VFAAVSTTVVGQNIAFDFLRNNW 919
            :.|:::....|..:           :.||:..:....||.: :|..::..::  .:|::|  .:|
  Fly   769 ISCTRDYETHYHKMIISGTESVEQKKIGIARMYEENPDLVQAIFEMITENIM--ELAYNF--QSW 829

  Fly   920 QEIKTYMGSQMSSIHTL---------FKFATKGFNSKFQLGEFENFVKDAHWDYDRPVQQIVEHI 975
            .:....: :.|:...|.         |.::...|     .||.|..:..:           :..:
  Fly   830 SDTAEVI-NDMAEYFTTREQQQLLKEFYYSNHQF-----FGESEELLSKS-----------LVTV 877

  Fly   976 ETSVDWMNKNYKSIVRWL 993
            |.:::|...:.:.:|::|
  Fly   878 EKNLNWAETHLEGLVKYL 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	134/415 (32%)
		M1_APN_2	121..576	CDD:189008	145/478 (30%)
		ERAP1_C	652..974	CDD:288671	73/346 (21%)
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	134/415 (32%)
		M1_APN_2	34..492	CDD:189008	145/478 (30%)
		ERAP1_C	567..874	CDD:288671	73/344 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	6	6.020