DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and CG8774

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster

Alignment Length:	996	Identity:	325/996 - (32%)
Similarity:	497/996 - (49%)	Gaps:	115/996 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 ILLASFFICTLLAVGFIVYNFATC------AELEPDSDE-----DVVCTSYHLRRLKAGHDDTPK 107
            :.|:.:::..:|:...:.:..||.      |:||.|..:     ||........|.:...:||..
  Fly     1 MFLSGYWLQVVLSWAVVAFATATVVVAVQKAQLERDLRDVQDKIDVFEEWSGESRTRMKREDTTD 65

  Fly   108 YDRDVRLPHSIRPLKYNITIEPQL-SGNFTFAGSVQIRIRVLEDCYNITMHAEELNISRSDASVH 171
            |    |||.::.|..|.:...|.| :||||  |..:|.|:|:|....|.:|:..|:|:    ||:
  Fly    66 Y----RLPTNLVPTHYELYWHPDLETGNFT--GQQRISIKVVEATNQIILHSYLLDIT----SVY 120

  Fly   172 RVQNNGEPEGDGLRIHKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQGFYRSSYEV 236
             |.|.        .:.|..|...:||.:|.|.::|..|....:.:.|.|.::|.|.|.|.|:|
  Fly   121 -VLNR--------EVEKFELEEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTY-- 174

  Fly   237 HNE---TRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPR-NMTTISNMPIVSSNDHATMP 297
            .||   ||.:::|:|:.|.||:|||||||||:||.|.:.:..|. :...:|||....||
  Fly   175 LNEAGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESN------ 233

  Fly   298 SYVWDH----FAESLPMSTYLVAYAISDFTHISSG----------NFAVWARADAIKSAEYALSV 348
             |:.|:    |..|:.||||||...:|||...|:.          :...:|.:..|...|:||..
  Fly   234 -YLGDYTEAIFETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEF 297

  Fly   349 GPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASV 413
            |..:..:...::.|.:||.|:||.|:|:|.:||||:|||:|:||||:||||..::..|||.:|..
  Fly   298 GQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGT 362

  Fly   414 VGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDALS 478
            :.||:||||||||||..||:|:|||||||.||:|...:||.|:|..|:||.:..||.|...||..
  Fly   363 LAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKL 427

  Fly   479 TSHKISHEVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLW 543
            :||.|..:|.:|.||:.|||.|||.||.::|||:...:....|...::.||.:..:|:...||
  Fly   428 SSHPIVQKVESPDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDD-- 490

  Fly   544 HFLT-VEAKSSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVYTNTTREDE- 606
             ||| |||..:.|     .:|::|.|||.|.||||:.||:..:.. .::.|.||:....:.|:.
  Fly   491 -FLTEVEAVVTDL-----DIKKLMLTWTEQMGYPVLNVSKVADGS-FKVTQQRFLSNPASYEEAP 548

  Fly   607 -----SLLWYIPITFTTD--SELNFANTRPTTWMPRTKLYELENRELSLA-----KWFIFNVQQT 659
                 ...|.:|||:..|  ||.:|             :|:.:...:.:|     :|...||.||
  Fly   549 SDSAYGYKWSVPITWFADDGSENSF-------------IYDYDVDSVGIAVPSEVQWIKLNVNQT 600

  Fly   660 GYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHEL 724
            |||||||:...|..:.:.|.......:|  |:|..|::|...||..:.|||:..:::|.||..|.
  Fly   601 GYYRVNYEESLWALLIQQLTTSPARFEI--ADRGHLLNDAFALADANQLSYKIPLDMTAYLAQER 663

  Fly   725 GHVPWKAAISNFIFIDSMFVNSGDYDLLKNYLLKQLKKVYDQVGFKDSQDESEDILVKLKRADIL 789
            ..|||..|.:....:....:.|..|.....|....:..||::||:....|..   |....|..||
  Fly   664 DFVPWYVASNKLRSLHRSLMFSEGYVSYLTYARSLIAGVYEEVGWTVDADNH---LKNRLRVSIL 725

  Fly   790 SMACHLGHQECIAEASRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQYGT-EYEWDFAFERFLK 853
            :.||.||..:|:.:||..|..:::.|....:    |:||.:||...:|..| :..||..|:.|:.
  Fly   726 TAACALGVPDCLQQASERFSTFLENPTTRPS----PDLREIVYYYGMQQSTSQSSWDQLFQLFVA 786

  Fly   854 TNVPGEKDLLLNALGCSKEPWLLYRFLRRGISGQHI-RKQDLFRVFAAVSTTVVGQNIAFDFLRN 917
            .....||..|:..|...:....|:.||.:..|.:.| |.||.|.....::...||:.:.::|.|.
  Fly   787 ETDASEKLKLMYGLSGVRNSQYLFDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVWEFYRE 851

  Fly   918 NWQEIKTYMGSQMSSIHTLFKFATKGFNSKFQLGEFENFVKDAHWDYDRPVQ------QIVEHIE 976
            .|.::.|..|....:...|....|..|.|..:|.|.::|..    .|.....      :.||.|:
  Fly   852 QWPQLTTRFGLNNRNFGRLIAQITANFASSVKLEEVQHFFS----KYPESGAGANSRLEAVETIK 912

  Fly   977 TSVDWMNKNYKSIVRWLENEA 997
            .:::|:::|...|..||...|
  Fly   913 YNIEWLSRNEADITDWLSGTA 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	166/410 (40%)
		M1_APN_2	121..576	CDD:189008	187/474 (39%)
		ERAP1_C	652..974	CDD:288671	92/329 (28%)
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	166/410 (40%)
		M1_APN_2	75..518	CDD:189008	187/474 (39%)
		ERAP1_C	593..910	CDD:288671	92/329 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462041
Domainoid	1	1.000	133	1.000	Domainoid score	I3134
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3793
SonicParanoid	1	1.000	-	-		X67
	10	9.780