DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14516 and npepps

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_001157499.1	Gene:	npepps / 407726	ZFINID:	ZDB-GENE-060524-3	Length:	872	Species:	Danio rerio

Alignment Length:	904	Identity:	280/904 - (30%)
Similarity:	466/904 - (51%)	Gaps:	69/904 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 VRLPHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLEDCYNITMHAEELNI----------SRS 166
            ||||..:.|:.|.:.::|.|. :|||.|.::..:.|.:....|.|:..:::|          ...
Zfish     8 VRLPTDVYPVNYGLRLKPDLV-DFTFEGKLEAAVEVTQGTNQIVMNCADIDIITASFVPDGGEEI 71

  Fly   167 DASVHRVQNNGEPEGDGLRIHKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQGFYR 231
            :|:....||..|.                   |...:...|:.....:.:.|.|.:.|.::||||
Zfish    72 NATGFNYQNEDEK-------------------VTLCFPSTLQKGSGSLKIDFVGELNDKMKGFYR 117

  Fly   232 SSYEVHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSSNDHATM 296
            |.|....|.|:.|.|||:||||||||||:||||:||.|.:.:..|::...:|||.:|....:|..
Zfish   118 SKYSSSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDITLIVPKDRVALSNMNVVDRKPYAED 182

  Fly   297 PSYVWDHFAESLPMSTYLVAYAISDFTHISSGN-----FAVWARADAIKSAEYALSVGPRILTFL 356
            .|.|...||.:..|||||||:.|.::..:.|.:     ..|:......:..::||.|..:.|.|.
Zfish   183 QSLVEVKFATTPIMSTYLVAFVIGEYDFVESQSSDGVTVRVYTPVGKAEQGKFALEVATKTLPFY 247

  Fly   357 QDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQ 421
            :|:|:|.:||||||:||:.:|.|||||||||:|:||||:|.||..:.|:::|.||.|||||||||
Zfish   248 KDYFSVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCASSRQWVALVVGHELAHQ 312

  Fly   422 WFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDALSTSHKISHE 486
            |||||||..||:.:||||||||::|||..|...||:....|||..:......||||..||.|..:
Zfish   313 WFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRALDLDALDNSHPIEVD 377

  Fly   487 VFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLWHFLTVEAK 551
            |.:|.|:.||||.|||:||:::|||:.:::.:..||:|::.||.:..:.:|:.:|||..|   .:
Zfish   378 VGHPSEVDEIFDAISYSKGASVIRMLHNYIGDEDFRKGMNAYLLKFQHKNASTEDLWECL---EQ 439

  Fly   552 SSGLLDDSRSVKEIMDTWTLQTGYPVVKV--SRHPNSDVIRLEQVRFVYTNTTREDESLLWYIPI 614
            :||     :.:..:|::||.|.|:|::.|  .:|.:..|:::.|.:|..:....:::...|.:||
Zfish   440 ASG-----KPIAAVMNSWTKQMGFPIIVVDQEQHGSDRVLKISQKKFCASGPRNDEDCPNWMVPI 499

  Fly   615 TFTTDSELNFANTRPTTWMPRTKLYELENRELSLAKWFIFNVQQTGYYRVNYDLENWMAITEHLM 679
            :..|..:.:...|:.....|.|.: .:.|  ::...|...|....|:||:.|.    .|:.|.|:
Zfish   500 SICTSEDPSCTKTKILLDQPETTV-NITN--VAPDHWIKINPGTVGFYRIQYS----SAMLESLL 557

  Fly   680 DVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAISNFIFIDSMFV 744
            .......:.|.:|..|.:|:.:|||...:|....:.:.....:|..:..|.....|...:.|:..
Zfish   558 PGIRDLTLLPVDRLGLQNDLFSLARAGMISTVEVLKVMEAFVNEPNYTVWSDLSCNLGVLSSLLS 622

  Fly   745 NSGDYDLLKNYLLKQLKKVYDQVGFKDSQDE--SEDILVKLKRADILSMACHLGHQECIAEASRH 807
            ::..::.::.:    ::.::..:|.|...|.  .|..|..|.|..:|......||:..:.||.|.
Zfish   623 HTDFHEDIQEF----IRDLFTPIGMKLGWDSRTGEGHLDALLRGLVLGKLGKAGHKATLEEARRR 683

  Fly   808 FQNWMQTPNPDSNNPIVPNLRGVVYCSAIQYGTEYEWDFAFERFLKTNVPGEKDLLLNALGCSKE 872
            |:.     :.:....:..:||..||.:.:::|.....|...:...:.::..||:.:...||....
Zfish   684 FRE-----HVEGKQILSADLRSPVYLTVLKHGDSTTLDTMLKLHKQADMQEEKNRIERVLGAIPA 743

  Fly   873 PWLLYRFLRRGISGQHIRKQDLFRVFAAVS-TTVVGQNIAFDFLRNNWQEI-KTYMGSQMSSIHT 935
            |.|:.|.|...:| :.:|.||...|...|: ::..|:..|:.|:::||:|: ..|.|..:  |..
Zfish   744 PDLIQRVLNFALS-EEVRPQDTVSVIGGVAGSSKQGRKAAWKFVKDNWEELHNRYQGGFL--ISR 805

  Fly   936 LFKFATKGFNSKFQLGEFENFVKDAHWD-YDRPVQQIVEHIETSVDWMNKNYKSIVRWL 993
            |.|....||.......|.::|.:..|.. .:|.|||..|:|..:..|:.::...|.::|
Zfish   806 LIKLTVDGFAIDKMAAEVKSFFESHHAPAAERTVQQCCENILLNAAWLKRDADDIHQYL 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	163/406 (40%)
		M1_APN_2	121..576	CDD:189008	181/469 (39%)
		ERAP1_C	652..974	CDD:288671	74/326 (23%)
npepps	NP_001157499.1	Peptidase_M1	9..396	CDD:279741	163/406 (40%)
		M1_APN_2	17..459	CDD:189008	181/469 (39%)
		ERAP1_C	534..845	CDD:288671	74/326 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820