DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and LTA4H

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_000886.1	Gene:	LTA4H / 4048	HGNCID:	6710	Length:	611	Species:	Homo sapiens

Alignment Length:	666	Identity:	144/666 - (21%)
Similarity:	242/666 - (36%)	Gaps:	171/666 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 TCAELEPDSDEDVVCTSYHLRRLKAGHDDTPKYDRDVRLPHSIRPLKYNITIEPQLSGNFTFAGS 140
            ||:...|.|    ||.:.|| .|:...|.|.:                            |..|:
Human     7 TCSLASPAS----VCRTKHL-HLRCSVDFTRR----------------------------TLTGT 38

  Fly   141 VQIRIRVLEDCYNITMHAEELNISRSDASVHRVQNNGEPEGDGLRIHKQYLVGAKQFF-----VI 200
            ..:.::..||      :...|.:...|.::.:|..||:        ..:|.:|.:|.:     .|
Human    39 AALTVQSQED------NLRSLVLDTKDLTIEKVVINGQ--------EVKYALGERQSYKGSPMEI 89

  Fly   201 ELYDKLLKDVEYVVHLRFDGIIEDYLQGFYRSSYEVHNETRWVAS------------TQFQATDA 253
            .|...|.|:.|.|:.:.|:             :....:..:|:..            :|.||...
Human    90 SLPIALSKNQEIVIEISFE-------------TSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHC 141

  Fly   254 RRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSSNDHATMPSYVWDHFAESLPMSTYLVAYA 318
            |...||.|.|::|..:|..::.|:.:..:.:............||.....|.:.:|:..||:|..
Human   142 RAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALV 206

  Fly   319 ISDFTHISSG-NFAVWARADAIKSAEYALSVGPRILTFLQDFFNVTFPLPKIDMIAL-PEFQAGA 381
            :........| ...||:..:.::.:.|..|....:|...:| ....:...:.|::.| |.|..|.
Human   207 VGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAED-LGGPYVWGQYDLLVLPPSFPYGG 270

  Fly   382 MENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYME 446
            ||| ..:||....:|       |.:|. :::|:.||::|.|.|||||...|...|||||...|:|
Human   271 MEN-PCLTFVTPTLL-------AGDKS-LSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLE 326

  Fly   447 YLTADAVAPE----------WKQLDQFVVNELQAVFQLDALSTSHKISHEVFNPQEISE--IFDR 499
            ......:..|          |.:|...|          .....:|..:..|.:..:|..  .:..
Human   327 RHICGRLFGEKFRHFNALGGWGELQNSV----------KTFGETHPFTKLVVDLTDIDPDVAYSS 381

  Fly   500 ISYAKGSTIIRMMAHFLTNP-IFRRGLSKYLQEMAYNSATQDDLWHFLTVEAKSSGLLDDSRSVK 563
            :.|.||..::..:...|..| ||...|..|:::.:|.|.|.||...||....|      |...|.
Human   382 VPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFK------DKVDVL 440

  Fly   564 EIMD--TWTLQTGYPVVKVSRHPNSDV------IRLEQVRFVYTNTTREDESLLWYIPITFTTDS 620
            ..:|  .|....|.|.:|    ||.|:      |.|.| |::   |.:||
Human   441 NQVDWNAWLYSPGLPPIK----PNYDMTLTNACIALSQ-RWI---TAKED--------------- 482

  Fly   621 ELNFANTRPTTWMPRTKLYELENRELSLAKWFIFNVQQT----GYYRVNYDLENWMAITE----- 676
            :||..|.        |.|.:|.:.:|:  ::....:|:.    |:.:...::.|:.||..
Human   483 DLNSFNA--------TDLKDLSSHQLN--EFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRF 537

  Fly   677 ---HLMDVDNFEDIAP 689
               .|.....:||..|
Human   538 RWLRLCIQSKWEDAIP 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	84/422 (20%)
		M1_APN_2	121..576	CDD:189008	105/488 (22%)
		ERAP1_C	652..974	CDD:288671	9/50 (18%)
LTA4H	NP_000886.1	leuko_A4_hydro	6..608	CDD:274120	144/666 (22%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18804029	135..137		1/1 (100%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18804029	267..272		1/4 (25%)
		Inhibitor ARM1 binding. /evidence=ECO:0000269\|PubMed:24591641	362..365		0/2 (0%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18804029	564..566
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810