DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and LNPEP

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_005566.2	Gene:	LNPEP / 4012	HGNCID:	6656	Length:	1025	Species:	Homo sapiens

Alignment Length:	1030	Identity:	310/1030 - (30%)
Similarity:	518/1030 - (50%)	Gaps:	143/1030 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LNMESRPMNAATPTTTTTFSKGGRR-----YSVSLTTAILLASFFICTLLAVGFIVY-------- 72
            :|..|...|:||         |.|:     .||.....:::.:|.|...::|..::|
Human    82 MNRSSGLRNSAT---------GYRQSPDGACSVPSARTMVVCAFVIVVAVSVIMVIYLLPRCTFT 137

  Fly    73 ---------------NFATCAELEPDSDEDVVCTSYHLRRLKAGHDDTPKYDRDVRLPHSIRPLK 122
                           .|||..:|.|.:                          .:|||.::.||:
Human   138 KEGCHKKNQSIGLIQPFATNGKLFPWA--------------------------QIRLPTAVVPLR 176

  Fly   123 YNITIEPQLSGNFTFAGSVQIRIRVLEDCYNITMHAEELNISRSDASVHRVQNNGEPEGDGLR-- 185
            |.:::.|.|: :.||.|||.|.::.|:..:||.:|:...||||  .:.....::.|.:.:.|.
Human   177 YELSLHPNLT-SMTFRGSVTISVQALQVTWNIILHSTGHNISR--VTFMSAVSSQEKQAEILEYA 238

  Fly   186 IHKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQGFYRSSY-EVHNETRWVASTQFQ 249
            .|.|..:.|.        :.||....|.:.:.:...|.....|||..|| :..||.::.|:|||:
Human   239 YHGQIAIVAP--------EALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFE 295

  Fly   250 ATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSS---NDHATMPSYVWDHFAESLPMS 311
            ...||.|||||||||.||.|.:.|.|....|.:||||..||   :|     ..|.|.|:||:.||
Human   296 PLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDD-----GLVQDEFSESVKMS 355

  Fly   312 TYLVAYAISDFTHIS---SGNF-AVWARADAIKSAEYALSVGPRILTFLQDFFNVTFPLPKIDMI 372
            |||||:.:.:..::|   :|.. :::|..:.|....|||....::|.|.|::|.:.:||.|:|::
Human   356 TYLVAFIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLV 420

  Fly   373 ALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWL 437
            |:|:|:|||||||||:||||..:|||...::..:::.|..::.|||||||||||||..||:|:||
Human   421 AIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWL 485

  Fly   438 NEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQL---DALSTSHKISHEVFNPQEISEIFDR 499
            |||||::|||.:.:.:..|....:.|    |.|.|:.   |:|::||.||..|.:.::|.|:||.
Human   486 NEGFATFMEYFSLEKIFKELSSYEDF----LDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDS 546

  Fly   500 ISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLWHFLTVEAKSSGLLDDSRSVKE 564
            :||.|||:::.|:..:|:..:|:..:..||...:|.|...||||.      ..:.:.:.:..||.
Human   547 LSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWD------SFNEVTNQTLDVKR 605

  Fly   565 IMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVYTNTTRE----DESLLWYIPITFTTDSELNFA 625
            :|.|||||.|:|:|.|.:  ....:.::|.|| :.|...|    |.|.||:||:::.|:.. |::
Human   606 MMKTWTLQKGFPLVTVQK--KGKELFIQQERF-FLNMKPEIQPSDTSYLWHIPLSYVTEGR-NYS 666

  Fly   626 NTRPTTWMPRTKLYELENRELSLAK---WFIFNVQQTGYYRVNYDLENWMAITEHLMDVDNFEDI 687
            ..:..:      |.:.::..::|.:   |...|:...|||.|:|..::|.|:. |.:.::.:. :
Human   667 KYQSVS------LLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALI-HQLKINPYV-L 723

  Fly   688 APANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAISNFIFIDSMFVNSGDYDLL 752
            :..:||.||:::..||....:..:.|.:|..|||:|....|...|:.....|.::....|..||.
Human   724 SDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLEKLGYMDLA 788

  Fly   753 KNYLLKQLKKVYDQVGFKDSQDESEDILVKLKRADILSMAC--HLGHQECIAEASRHFQNWMQTP 815
            ...:.:..|.:.:|:..:...||....:.:|:.| :|..||  :||:  |...|.:.|.:||.:.
Human   789 SRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSA-LLEFACTHNLGN--CSTTAMKLFDDWMASN 850

  Fly   816 NPDSNNPIVPNLRGVVYCSAIQYG--TEYEWDFAFERFLKTNVPGEKDLLLNALGCSKEPWLLYR 878
            ...|       |...|..:..:.|  |:..|.|...:::......||:.:|.||..|::...||.
Human   851 GTQS-------LPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYW 908

  Fly   879 FLRRGISGQHIRKQDLFRVFAAVSTTVVGQNIAFDFLRNNWQEI--KTYMGSQMSSIHTLFKFAT 941
            .::..::|.:.|.|.|..:...|.....|..:|:||::.||.::  |..:||.  :|..:...:|
Human   909 LMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSY--TIQNIVAGST 971

  Fly   942 KGFNSKFQLGEFENFVK---DAHWDYDRPVQQIVEHIETSVDWMNKNYKSIVRWL 993
            ..|::|..|.|.:.|.:   :|.:.. |.||:.:|.|:.::.||.||.||:..||
Human   972 YLFSTKTHLSEVQAFFENQSEATFRL-RCVQEALEVIQLNIQWMEKNLKSLTWWL 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	157/404 (39%)
		M1_APN_2	121..576	CDD:189008	176/467 (38%)
		ERAP1_C	652..974	CDD:288671	83/330 (25%)
LNPEP	NP_005566.2	Dileucine internalization motif. /evidence=ECO:0000255	53..54
		Dileucine internalization motif. /evidence=ECO:0000255	76..77
		Tankyrase binding	96..101		1/4 (25%)
		M1_APN_2	175..617	CDD:189008	176/467 (38%)
		Substrate binding. /evidence=ECO:0000250	428..432		3/3 (100%)
		ERAP1_C	689..1009	CDD:314669	86/334 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820