DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and Psa

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster

Alignment Length:	1073	Identity:	309/1073 - (28%)
Similarity:	524/1073 - (48%)	Gaps:	152/1073 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NFKPIMVV---KEIPLHENLNMESRPMNAATPTTTT------------------TFSKGGRRY-- 46
            |..|.:|.   :..|::.......:|..||..||:.                  .|.|..:::
  Fly    73 NSSPRIVANYYRTAPVNPPKQQNPKPSGAADKTTSVKHLFRAESGHLNALISSKQFVKVQKQFYR 137

  Fly    47 ---SVSL------TTAILLASFFICT----LLAVGFIVYNFATCAELEPDSDEDVVCTSYHLRRL 98
               ||||      :.|.||..  :|:    :||        .|.|::.|..|......:|  :::
  Fly   138 DFSSVSLGAPLKSSDAPLLGD--LCSQYRAILA--------HTSADVIPGQDRHHPGCNY--QQI 190

  Fly    99 KAGHDDTPKYDRDV-------------RLPHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLED 150
            :..|......::.:             |||.::.|..|.:.::|.|. .|||.|...:::.|.|.
  Fly   191 RRAHTQLLSKEQQLEQERKMAQKAKFERLPTNVVPRHYELLLQPNLK-EFTFTGKTVVQVNVKEP 254

  Fly   151 CYNITMHAEELNISRSDASVHRVQNNGEPEGDGLRIHKQYLVGAKQFFVIELYDKLLKDVEYVVH 215
            ...||::|  |:|......:|...:..:||       |.......:...:|...::..:.:.|:|
  Fly   255 TTQITLNA--LDIVLDSVELHFECSKLKPE-------KIVYSAENETATLEFAQEIPAETQGVLH 310

  Fly   216 LRFDGIIEDYLQGFYRSSYEVHN-ETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNM 279
            :.|.|.:.|.::|||||.|...| |.|:...|||:||||||.|||:||||:||.|.:.:..|::.
  Fly   311 MSFTGELNDKMKGFYRSKYFGPNGEERFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDR 375

  Fly   280 TTISNMPIVSSNDHATMPSYVWDHFAESLP-------------MSTYLVAYAISDFTHISSGN-- 329
            ..:||||::..               :|||             |||||||..:.::.::...:
  Fly   376 VALSNMPVIKE---------------DSLPDGLRRVRFDRTPIMSTYLVAVVVGEYDYVEGKSDD 425

  Fly   330 ---FAVWARADAIKSAEYALSVGPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFR 391
               ..|:......:...:||.|..::|.:.:|:||:.:||||:|:||:.:|.|||||||||:|:|
  Fly   426 GVLVRVFTPVGKREQGTFALEVATKVLPYYKDYFNIAYPLPKMDLIAISDFSAGAMENWGLVTYR 490

  Fly   392 ETAMLYDPGVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPE 456
            ||.:|.||...:...||.:|..||||:||||||||||..||:.:|||||:||::|:|....:.||
  Fly   491 ETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGNLVTMEWWTHLWLNEGYASFVEFLCVHHLFPE 555

  Fly   457 WKQLDQFVVNELQAVFQLDALSTSHKISHEVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIF 521
            :....|||.:......:||:|..||.|...|.:|.||.||||.|||.||:::|||:..::....|
  Fly   556 YDIWTQFVTDMYTRALELDSLKNSHPIEVPVGHPSEIDEIFDEISYNKGASVIRMLHDYIGEDTF 620

  Fly   522 RRGLSKYLQEMAYNSATQDDLWHFLTVEAKSSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRH--- 583
            |:|::.||....|.:...:|||..|. ||       .|::|.::|.:||...|:|||.|...
  Fly   621 RKGMNLYLTRHQYGNTCTEDLWAALQ-EA-------SSKNVSDVMTSWTQHKGFPVVSVESEQTS 677

  Fly   584 PNSDVIRLEQVRFVYTNTTREDESLLWYIPITFTTDSELNFANTRPTTWMPRTKLYELENRELSL 648
            .|..::||:|.:|. .:.::.||:.||.:||:.:|        ::..|.:.:|.|.:..:.|::|
  Fly   678 KNQRLLRLKQCKFT-ADGSQADENCLWVVPISVST--------SKNPTGIAKTFLLDKSSMEVTL 733

  Fly   649 AK-----WFIFNVQQTGYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYL 708
            ..     |...|....||||..|..|    :.|.||......::.|.:|..||||:..:.:..:.
  Fly   734 DNVDEDDWIKINPGTVGYYRTRYSQE----MLEQLMPAVEKMELPPLDRLGLIDDMFAMVQAGHA 794

  Fly   709 SYETAMNLTRYLGHELGHVPWKAAISNFIFIDSMFVNSGDYDLLKNYLLKQLKKVYDQVGFKDSQ 773
            |....:.|.....:|..:..| .||:|  .:.::.:.....||:::: .:..:.:|:.|.::...
  Fly   795 STADVLALVDSYRNETNYTVW-TAITN--SLTNLHILISHTDLMEDF-HRFGRNLYEPVAYRLGW 855

  Fly   774 D--ESEDILVKLKRADILSMACHLGHQECIAEASRHFQNWMQTPNPDSNNPIVP-NLRGVVYCSA 835
            :  :.|:.|..|.|:.:|:........:.|.||...|:..:      :...::| :||...|.:.
  Fly   856 EPRDGENHLDTLLRSLVLTRLVSFRSSDTIEEAKIRFRRHV------NGTELLPADLRTTCYKAV 914

  Fly   836 IQYGTEYEWDFAFERFLKTNVPGEKDLLLNALGCSKEPWLLYRFLRRGISGQHIRKQDLFRVFAA 900
            :|.|.|..::...:.:..|::..|:|.:..||||..:..||.|.:...:|.: :|.||...|..|
  Fly   915 LQDGDEKIFNEMLDLYRATDLHEEQDRISRALGCCGDLKLLRRVIDFAMSSE-VRAQDSVFVIVA 978

  Fly   901 VSTTVVGQNIAFDFLR-NNWQEIKTYMGSQMSSIHTLFKFATKGFNSKFQLGEFENFVK-DAHWD 963
            |:....|:::|::|.: ||.|.::.|.|..:.|  .|.|:..:.|.|:.:..|.|.|:: :....
  Fly   979 VAINPKGRDMAWEFFKENNKQLLERYQGGFLLS--RLIKYLIENFASEERAKEVEEFLQVNQIPG 1041

  Fly   964 YDRPVQQIVEHIETSVDWMNKNYKSIVRWLENE 996
            .:|.|.|.||.|..:..|:.::.:.:..:|.::
  Fly  1042 CERTVSQAVETIRLNAAWLQRDREQLAIFLRDD 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	153/410 (37%)
		M1_APN_2	121..576	CDD:189008	172/473 (36%)
		ERAP1_C	652..974	CDD:288671	80/326 (25%)
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	153/410 (37%)
		M1_APN_2	227..667	CDD:189008	172/472 (36%)
		ERAP1_C	742..1052	CDD:288671	80/326 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462116
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	8	7.850