DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and CG3502

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_611781.3	Gene:	CG3502 / 37695	FlyBaseID:	FBgn0046253	Length:	912	Species:	Drosophila melanogaster

Alignment Length:	944	Identity:	278/944 - (29%)
Similarity:	449/944 - (47%)	Gaps:	137/944 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 DVRLPHSIRPLKYNITIEPQL-SGNFTFAGSVQIRIRVLEDCYNITMHAEELNISRSDAS----- 169
            |.|||.|:.||.||:.|...| |.:..|.|||.|.:...|...|||:||..|.|..:..|
  Fly    27 DYRLPRSVEPLHYNLRILTHLNSTDQRFEGSVTIDLLARETTKNITLHAAYLKIDENRTSVVSGQ 91

  Fly   170 ----VHRVQNNGEPEGDGLRIHKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQGFY 230
                |:|::.|        .:|        .|:::.|..:|:||..|.:.:.|...:.|...|:|
  Fly    92 EKFGVNRIEVN--------EVH--------NFYILHLGRELVKDQIYKLEMHFKAGLNDSQSGYY 140

  Fly   231 RSSY------EVHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVS 289
            :|:|      |||:    :|.|||..|.||:||||||||:.||.|.:.:...:....:|.||::.
  Fly   141 KSNYTDIVTKEVHH----LAVTQFSPTFARQAFPCFDEPSWKATFNITLGYHKKYMGLSGMPVLR 201

  Fly   290 SNDHATMPSYVWDHFAESLPMSTYLVAYAISDFTHISSGN--------FAVWARADAIKSAEYAL 346
            ..||.::.:|||......|..||||||:|:.|..:.::..        |..|.:...:.....::
  Fly   202 CQDHDSLTNYVWCDHDTLLRTSTYLVAFAVHDLENAATEESKTSNRVIFRNWMQPKLLGQEMISM 266

  Fly   347 SVGPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVA 411
            .:.|::|:|.::.|.:.|||.|:|.:.:|..:..|||||||:|:.|..:..:.|......|...|
  Fly   267 EIAPKLLSFYENLFQINFPLAKVDQLTVPTHRFTAMENWGLVTYNEERLPQNQGDYPQKQKDSTA 331

  Fly   412 SVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDA 476
            ..|.||.||||||||||.:||:|:||.||.::|..||..|::.|||::.::|:..:|...|..|:
  Fly   332 FTVAHEYAHQWFGNLVTMNWWNDLWLKEGPSTYFGYLALDSLQPEWRRGERFISRDLANFFSKDS 396

  Fly   477 LSTSHKISHEVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDD 541
            .:|...||.:|.||.|:...|....|.|||..|||:...:....|..|:..:|:..::.:..|.|
  Fly   397 NATVPAISKDVKNPAEVLGQFTEYVYEKGSLTIRMLHKLVGEEAFFHGIRSFLERFSFGNVAQAD 461

  Fly   542 LWHFLTVEAKSSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVYTNTTREDE 606
            ||:.|.:.|..:.::....::...||:||||.|||:|.:.|:..:..:.|.|.|| :.....|..
  Fly   462 LWNSLQMAALKNQVISSDFNLSRAMDSWTLQGGYPLVTLIRNYKTGEVTLNQSRF-FQEHGIEKA 525

  Fly   607 SLLWYIPITFTTDSELNFANTRPTTWMP---RTKLYELENRELSLAKWFIFNVQQTGYYRVNYDL 668
            |..|::|:.|...:..:|..|.|..|:.   .||:.:|.: .||..:|.|.|.|....:|||||.
  Fly   526 SSCWWVPLRFVRQNLPDFNQTTPQFWLECPLNTKVLKLPD-HLSTDEWVILNPQVATIFRVNYDE 589

  Fly   669 ENWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAI 733
            .||..|.|.|.:..|...|...|:|||:||:|.||......|:.|.:|..||..|...:||:.||
  Fly   590 HNWRLIIESLRNDPNSGGIHKLNKAQLLDDLMALAAVRLHKYDKAFDLLEYLKKEQDFLPWQRAI 654

  Fly   734 SNFIFIDSMFVNSGDYDLLKNYLLKQLKKVYDQV----GFKDSQDESEDILVKLKRADILSMACH 794
            .....:.:: :|..:.:..|||:.|.|..:|::.    |.::::...:||..   .....|.||.
  Fly   655 GILNRLGAL-LNVAEANKFKNYMQKLLLPLYNRFPKLSGIREAKPAIKDIPF---AHFAYSQACR 715

  Fly   795 LGHQECIAEA-----SRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQYGTEYEWDFAFERFLKT 854
            ....:|..:|     :...:..::.|:         :.:.|.|||.:..|.:.|:...|..|..:
  Fly   716 YHVADCTDQAKILAITHRTEGQLELPS---------DFQKVAYCSLLDEGGDAEFLEVFGLFQNS 771

  Fly   855 NVPGEKDLLLNALGCSK-----EPWLLYRF------------------LRRG----------IS- 885
            ....::.:|.:||||.:     |.:|.|..                  |.|.          ||
  Fly   772 TNGSQRRILASALGCVRNFGNFEQFLNYTLESDEKLLGDCYMLAVKSALNREPLVSPTANYIISH 836

  Fly   886 ----GQHIRKQDLFRVFAAVSTTVVGQNI----AFDFLRNNWQEIKTYMGSQMSSIHTLFKFATK 942
                |:..:|::|..:..:::     ||:    ..|.|:...:::|.:.       ..|.|...:
  Fly   837 AKKLGEKFKKKELTGLLLSLA-----QNLRSTEEIDRLKAQLEDLKEFE-------EPLKKALYQ 889

  Fly   943 G-FNSKFQLGEFENFVKDAHWDYDRPVQQIVEHI 975
            | .|.|:|        ||...|:   ::.|.:|:
  Fly   890 GKMNQKWQ--------KDCSSDF---IEAIEKHL 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	143/415 (34%)
		M1_APN_2	121..576	CDD:189008	160/478 (33%)
		ERAP1_C	652..974	CDD:288671	88/373 (24%)
CG3502	NP_611781.3	Peptidase_M1	29..425	CDD:279741	143/415 (34%)
		M1_APN_2	37..496	CDD:189008	160/478 (33%)
		ERAP1_C	573..890	CDD:288671	80/341 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462073
Domainoid	1	1.000	114	1.000	Domainoid score	I6014
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	8	7.850