DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and CG10602

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_609916.5	Gene:	CG10602 / 35146	FlyBaseID:	FBgn0032721	Length:	684	Species:	Drosophila melanogaster

Alignment Length:	755	Identity:	174/755 - (23%)
Similarity:	274/755 - (36%)	Gaps:	210/755 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 VCTSYHLRRLKAGHDDTPKYD---RDVRLPHSIRPLKYN----ITIE-PQLSGNFTFA-----GS 140
            :|||:.|         .|.|.   |::.....:.|..|:    ||.| ..|:....||     ||
  Fly    55 LCTSHKL---------LPIYQVQKRNMGRLGVVDPSSYSQPDLITTEHSALNWKIDFAATKIQGS 110

  Fly   141 VQIRIRVL-EDCYNITMHAEELNISRSDASVHRVQNNGEPEGDGLRIHKQYLVGAKQ----FFVI 200
            |..|.:|| .:...|.:...::|::.:                      ..|.|..:    ||:.
  Fly   111 VLHRFKVLTANLDKILLDVRDINVTNA----------------------TLLAGGSELPINFFIS 153

  Fly   201 ELYDKLLKDVEYVVHLRF-DGIIEDYLQGFYRSSYEVHNET---RWVAST------------QFQ 249
            :..|    |:...:.|.. .|..:..|.  .|..||..:..   :|:..|            |.|
  Fly   154 DAVD----DIGQKLTLELPSGTAKGSLN--VRIDYETSSSASGLQWLNPTQTLGKEHPYMFSQCQ 212

  Fly   250 ATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSSNDHATMPSYVWDHFAESLPMSTYL 314
            |..||...||.|.||:|..:...:..|..:|.:.:..|.......|:       |.:.:|:..||
  Fly   213 AIHARSVIPCQDTPAVKFTYDATVEHPSELTALMSALIDKKEPGKTL-------FKQEVPIPAYL 270

  Fly   315 VAYAISDFTHISSG-NFAVWARADAIKSAEYALSVGPRILTFLQDFFNVTFPL--PKIDMIAL-P 375
            ||.||........| |.:|||....:.:.....|   ...|.|:....:..|.  .:.|::.: |
  Fly   271 VAIAIGKLVSRPLGENSSVWAEEAIVDACAEEFS---ETATMLKTATELCGPYVWKQYDLLVMPP 332

  Fly   376 EFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEG 440
            .|..|.||| ..:||....:|       |.:|. :|.||.||:||.|.|||||...:...|||||
  Fly   333 SFPFGGMEN-PCLTFVTPTLL-------AGDKS-LADVVAHEIAHSWTGNLVTNKNFEHFWLNEG 388

  Fly   441 FASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDALSTSHK------ISHEVFNPQEISEI--- 496
            |..::|               ..:|..:|...:||....|:.      |..::....|::::
  Fly   389 FTVFVE---------------SKIVGRMQGAKELDFKMLSNLTDLQECIRTQLNKTPELTKLVVD 438

  Fly   497 ---------FDRISYAKGSTIIRMMAHFLTNP-IFRRGLSKYLQEMAYNSATQDDLW-----HFL 546
                     |..:.|.||||.:|.:......| :|...|..||::.||.|....|..     :|:
  Fly   439 LSNCGPDDAFSSVPYIKGSTFLRYLEDLFGGPTVFEPFLRDYLKKYAYKSIETKDFQSALYDYFI 503

  Fly   547 TVEAKSSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVYTNTTREDESLLW- 610
            ..:.|      |..|..: .|.|....|.|.|    .||.|    |.:    .|.|:|..| ||
  Fly   504 DTDKK------DKLSAVD-WDLWLKSEGMPPV----IPNFD----ESL----ANVTKELAS-LWS 548

  Fly   611 -----------YIPITFTTDSELNFANTRPTTWMPRTKLYE------LENRELSLAKWFIFNVQQ 658
                       .|..|.:....::|..          ||.|      |...:::|.: ..:|::.
  Fly   549 SKSVAELADSAEIKTTISIHQLIDFLG----------KLIESKDIVDLNEGKINLLE-STYNLKS 602

  Fly   659 TGYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLI---DDVMNLARGSYLSYETAMNLTRYL 720
            :....|.:.| |.:.|                 ||:||   |:::..|..::     .|...|.:
  Fly   603 SKNAEVRFRL-NRLII-----------------RARLIKRLDEILEFANSNF-----RMKFCRPI 644

  Fly   721 GHELGHVP--WKAAISNFIFIDSMFVNSGDYDLLKNYLLK 758
            ..:|...|  ..|||.||:.:....:....:.:.|:..||
  Fly   645 YRDLAGWPEAKPAAIRNFVNVKDQMMAVCSHTIEKDLGLK 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	103/444 (23%)
		M1_APN_2	121..576	CDD:189008	123/513 (24%)
		ERAP1_C	652..974	CDD:288671	23/112 (21%)
CG10602	NP_609916.5	Ribosomal_L13	16..>50	CDD:294238
		leuko_A4_hydro	79..681	CDD:274120	165/717 (23%)
		M1_LTA4H	79..520	CDD:189006	122/509 (24%)
		Leuk-A4-hydro_C	541..680	CDD:286244	32/173 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462064
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840