DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and CG31445

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster

Alignment Length:	921	Identity:	336/921 - (36%)
Similarity:	522/921 - (56%)	Gaps:	61/921 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 RLPHSIRPLKYNITIEPQLSG--NFTFAGSVQIRIRVLEDCYNITMHAEELNISRSDASVHRVQN 175
            |||.::||.:|.:.|...|..  :..|||:|||.|:.|::..|||:|::.|.|..|..::.::..
  Fly    28 RLPTALRPQRYYLRILTLLESPDDLRFAGNVQIVIKALQNTRNITLHSKNLTIDESRITLRQISG 92

  Fly   176 NGEPEGDGLRIHKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQGFYRSSYE--VHN 238
            .|..:.   .:....:.....:::.....:||....|.:.|.|...:...|.|:|||||:  |.|
  Fly    93 AGNMDN---CVSSTSVNPTHDYYIFHTCKELLAGNVYKLFLPFSADLTPQLFGYYRSSYKDPVTN 154

  Fly   239 ETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSSNDHATMPSYVWDH 303
            :|||:::|||:.:.||:||||||||..||:|.:.:...:....:||||:.....|.::.:|:|..
  Fly   155 KTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPHESLANYIWCE 219

  Fly   304 FAESLPMSTYLVAYAISDF-----THISSGNFAVWARADAIKSAEYALSVGPRILTFLQDFFNVT 363
            |.||:|||||||||:::||     |..:...|..|||.:||...:||...||::|.:.::||.:.
  Fly   220 FQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARPNAIDQCDYAAEFGPKVLQYYEEFFGIR 284

  Fly   364 FPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQWFGNLVT 428
            :||||||.:|:|:|.|||||||||:.:||:.:||.|..::..:||.:|:|:.|||||||||||||
  Fly   285 YPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAHQWFGNLVT 349

  Fly   429 PSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDALSTSHKISHEVFNPQEI 493
            ..||:|:|||||||:|:..|....:.|||...|:..:..|...|:||:|.:||.||..:....||
  Fly   350 MKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTALMTAFRLDSLVSSHPISRPIQMVTEI 414

  Fly   494 SEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLWHFLTVEAKSSGLLDD 558
            .|.||.|||.|||.::|||..|:....||.||.:||:..||.:|.|::||..||..|..:|.|..
  Fly   415 EESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLTTAAHQNGALPG 479

  Fly   559 SRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFV-YTNTTREDESLLWYIPITFTTDSEL 622
            ...:..|||:||||||:||:.::|..::....:.|.|:: .:...:.|....|::|:::||..|.
  Fly   480 HYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYLRNSQIPQADRVGCWWVPLSYTTQDEN 544

  Fly   623 NFANTRPTTWM---------PRTKLYELENRELSLAKWFIFNVQQTGYYRVNYDLENWMAITEHL 678
            :|.||.|..||         |.|..:.....|     |.|.|:|.:..|:.|||..||..:.:.|
  Fly   545 DFNNTSPKAWMECSSTDEGVPTTIDHSAGPEE-----WLILNIQLSTPYKANYDARNWKLLIDTL 604

  Fly   679 MDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAISNFIFIDSMF 743
            ...| |:.|...|||||||||:..|......||||:.:|.||..|...:|||:|:.|...::.:.
  Fly   605 NSKD-FQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSALDNLKLLNRIL 668

  Fly   744 VNSGDYDLLKNYLLKQLKKVYDQV-GFKDS---QDESEDILVKLKRADILSMACHLGHQECIAEA 804
            ..:.::...|.|:.|.|..:|:.: |..|:   ..:.:::|:|   ..::::||.....:|:.:|
  Fly   669 RQTPNFGSFKRYMQKLLTPIYEHLHGMNDTFSLMTQQDEVLLK---TTVVNVACQYDVSDCVTQA 730

  Fly   805 SRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQYGTEYEWDFAFERFLKTNVPGEKDLLLNALGC 869
            ..:|:.|....|||.|:|:..|||..|||:||..|||.:|:|.:.|:.|:||..|:..:|:.|||
  Fly   731 QAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYRKSNVASERQTILSTLGC 795

  Fly   870 SKEPWLLYRFLRRGISGQH-IRKQDLFRVFAAVSTTVVGQNIAFDFLRNNWQEIKTY-------- 925
            |||.|:|.|::.:....:. |||||....|.||::..||..:|..:...|.:.|..|
  Fly   796 SKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQYFIENVELIHKYYYPQTRVM 860

  Fly   926 ------MGSQMSSIHTLFKFATKGFNSKFQLGEFENFVKDAHWDYDRPVQQIVEHIETSVDWMNK 984
                  :..|:|:|:.|.||.:...:|:       :|:|...    :.:||.:|.:.|:|.||:.
  Fly   861 SRLLTPLSEQVSTINDLNKFRSFANDSR-------HFLKGIR----QAMQQSLETMLTNVQWMDW 914

  Fly   985 NYKSIVRWLEN 995
            ||....|.:.:
  Fly   915 NYHKFSRTIRH 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	165/400 (41%)
		M1_APN_2	121..576	CDD:189008	193/463 (42%)
		ERAP1_C	652..974	CDD:288671	109/340 (32%)
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	165/400 (41%)
		M1_APN_2	43..497	CDD:189008	191/456 (42%)
		ERAP1_C	578..904	CDD:288671	109/340 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462074
Domainoid	1	1.000	114	1.000	Domainoid score	I6014
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2057
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		mtm6446
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	11	10.700