DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and CG31343

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster

Alignment Length:	984	Identity:	287/984 - (29%)
Similarity:	470/984 - (47%)	Gaps:	100/984 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 LLASFFICTLLAVGFIVYNFATCAELEPDSDEDVVCTSYHLRRLKAGHDDTPKYDRDVRLPHSIR 119
            ||.||.:..||||..:.........|:....|......:...|:    ||...  .:.|||::..
  Fly     5 LLNSFSLILLLAVCSLQARLILPLSLDDGQLETKGAALFATSRV----DDNSA--GNYRLPNTTE 63

  Fly   120 PLKYNITIEPQL-SGNFTFAGSVQIRIRVLEDCYNITMHAEELN------ISRSDASVHRVQNNG 177
            |..||:.:...: :|:..|.|:|.|.||||.:..|||:|..:.:      |||..|:...:....
  Fly    64 PESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISRDVATPTAIPLTV 128

  Fly   178 EPEGDGLRIHKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQGFYRSSY-EVHNETR 241
            .||     :.:::|| ..|....|.:.   .:..:.:.:.:.||....:.|||.||| :...|..
  Fly   129 TPE-----LQREFLV-LTQTTAGEAFG---ANTNWTITINYTGIHRSDMGGFYISSYTDDDGEQH 184

  Fly   242 WVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSSNDHATMPSYVWDHFAE 306
            ::|:|||::|:||.||||:||||.:||||:.|....:.|.|||||:   |..||.....  .|..
  Fly   185 FLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPV---NTAATSSGVT--AFQT 244

  Fly   307 SLPMSTYLVAYAISDFTHISSGNF-----AVWARADAIKSAEYALSVGPRILTFLQDFFNVTFPL 366
            :..|||||||:.:||| ..::|..     .|::|.......|:||..|..:.:.|..:|.|.|.|
  Fly   245 TPKMSTYLVAFIVSDF-ESTTGELNGIRQRVFSRKGKQDQQEWALWSGLLVESSLASYFGVPFAL 308

  Fly   367 PKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQWFGNLVTPSW 431
            ||:|...:|:|.|||||||||.|:||..|.::...:|.|.|..:|:::|||.||.|||:||:..|
  Fly   309 PKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSIKW 373

  Fly   432 WSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDALSTSHKISHEVFNPQEISEI 496
            |:.:||.||||:...|.:.|...|.|.....|.||:..:....|||:::..::|.|..|.|||..
  Fly   374 WTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMTHYVQTPSEISNR 438

  Fly   497 FDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLWHFLTVEAKSSGLLDDSRS 561
            ::..||||.::::.|..:..|:.:||.||:|||.:..|.|..:.||:......|...|....: |
  Fly   439 YNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQESADELGFTLPA-S 502

  Fly   562 VKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVYTNTTREDESLLWYIPITFTTDSELNFAN 626
            |.:|..:|:.|.|||::.|:|:.|:..|.:.|.|:|...|  :..|..||:|:.|.|.::.::.:
  Fly   503 VDDIFSSWSHQAGYPLLTVTRNYNAGTITITQKRYVANKT--DTNSATWYVPLNFATANKYDYRD 565

  Fly   627 TRPTTWMPRTKLYELENRELSLAKWFIFNVQQTGYYRVNYDLENWMAITEHLMDVD-NFEDIAPA 690
            |..|.::.......:.:.|.|...|.|.|:|.:||||..||.:|:..||..|.... .|.   |.
  Fly   566 TSATHYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRFH---PR 627

  Fly   691 NRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAISNFIFIDSMFVNSGDYDLLKNY 755
            |||||:.|.........||:...:.|..||.:|..:.||..|.:.....|........|...:::
  Fly   628 NRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANTILTVYDRYLRGDDSYYNFQDF 692

  Fly   756 LLKQLKKVYDQVGFKDSQDESEDILVKLKRADILSMACHLGHQECIAEASRHFQNWMQTPNPDSN 820
            :.:.:..::|::|.  ::...|..|....|..::|:||.:|..:|..:::.....::.     :.
  Fly   693 VKRLIDPIFDKIGV--NEIPGEHYLNNYLRIVLVSLACQVGSDDCYNQSANKLSEYLY-----NG 750

  Fly   821 NPIVPNLRGVVYCSAIQYGTEYEWDFAFERFLKTNVPGEKDLLLNALGCSKEPWLLYRFLRRGI- 884
            ..|...|:...||:.::..|...:.......|.::...::.|.:::||||.....|..|||..:
  Fly   751 TAIEATLKTQAYCAGLRSTTNEIYSRVQSDLLSSSDSTDRSLFISSLGCSGSTSQLLDFLRLSLD 815

  Fly   885 ---SGQHIRKQDLFRVFAAVSTTVVGQNIAFDFLRNNWQE-----------------IKTYMGSQ 929
               |..:..:..|..  :|.|.:.:|...:.:||.:||:.                 |.||:.|:
  Fly   816 TNNSLSYSERTSLLN--SAYSRSEIGLTASLEFLESNWEAYANLSDSAKPLDAALRGIATYVVSE 878

  Fly   930 MSSIHTLFKFATKGFNSKFQLGEFENFVKDAHWDYDRPVQQIVEHIETSVD--------WMNKNY 986
                           ..|.:|....:.|     :.|.| ..|.:.:.|::|        |:..|.
  Fly   879 ---------------KQKTRLNALVDVV-----EADGP-SYINDDLSTTIDSRITSNFAWLEVNR 922

  Fly   987 KSIVRWLEN 995
            ..::.|:|:
  Fly   923 DPVLNWIED 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	149/404 (37%)
		M1_APN_2	121..576	CDD:189008	167/467 (36%)
		ERAP1_C	652..974	CDD:288671	76/343 (22%)
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	148/403 (37%)
		M1_APN_2	65..517	CDD:189008	167/467 (36%)
		ERAP1_C	591..886	CDD:288671	72/321 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462113
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	8	7.850