Protein Alignment CG14516 and TRHDE

DIOPT Version :9

• Sequence 1: NP_651674.3
• Gene: CG14516 / 43444
• FlyBaseID: FBgn0039640
• Length: 999
• Species: Drosophila melanogaster
• Sequence 2: NP_037513.2
• Gene: TRHDE / 29953
• HGNCID: 30748
• Length: 1069
• Species: Homo sapiens
• Alignment Length: 915
• Identity: 305/915 - (33%)
• Similarity: 489/915 - (53%)
• Gaps: 68/915 - (7%)

  Fly   112 VRLPHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLEDCYNIT----MHAEELNISRSDASVHR 172
            :||...::||.||:.:...:. ||||:|.|.:.|.    |.|.|    :||       |..:|.:
Human   184 LRLSGHLKPLHYNLMLTAFME-NFTFSGEVNVEIA----CRNATRYVVLHA-------SRVAVEK 236

  Fly   173 VQNNGEPEGDGLRIHKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQGFYRSSYEVH 237
            ||...:.....:.:...:|....|..|:.|...|.....|.:.:.::.:||:.|.||:||||.:|
Human   237 VQLAEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGFFRSSYVLH 301

  Fly   238 NETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSS---NDHATMPSY 299
            .|.|::..|||..|.||:||||||||..||.|.:.|.......::||||:.:|   .|     .:
Human   302 GERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEED-----GW 361

  Fly   300 VWDHFAESLPMSTYLVAYAISDFTH----ISSGNFA-VWARADAIK--SAEYALSVGPRILTFLQ 357
            |.|||:::..||||.:|:||.:||:    ..||... ::||.|||:  |.:|||.:..|::.|.:
Human   362 VTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYE 426

  Fly   358 DFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQW 422
            |:|.|.:.|||:|::|:|:....|||||||..|.|..:|.||.|::.:....|..|:.||:.|||
Human   427 DYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQW 491

  Fly   423 FGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWK-QLDQFVVNELQAVFQLDALSTSHKISHE 486
            ||:||||.||.|:||.||||.|.|::..|.:.|.|. :..:|:.:.|..|..||.|::||.:|.|
Human   492 FGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQE 556

  Fly   487 VFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLWHFLTVEAK 551
            |....:|..:||.|:|.||:.:|||:|:|:.:.:|:|||..||....|.:|.::|||:.|:...|
Human   557 VLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALK 621

  Fly   552 SSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSD-VIRLEQVRFVYTNTTR------EDESLL 609
            .:|   ...:::|:||.||||.||||:.:..:..:: .|.:.|..|:|..:.:      ::.|.|
Human   622 RNG---KYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYL 683

  Fly   610 WYIPITFTTDSELNFANTRPTTWMPRTKLYELENRE---LSLAKWFIFNVQQTGYYRVNYDLENW 671
            |.||:|....:. :..::....|:..    :.|:..   |....|.:.|:.||||:||||||.||
Human   684 WQIPLTIVVGNR-SHVSSEAIIWVSN----KSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNW 743

  Fly   672 MAITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAISNF 736
            ..:.:.|  :.|.|.::.:|||.||||..:|||..||.....:.:.|||..|...:||.||....
Human   744 RLLIDQL--IRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRAL 806

  Fly   737 IFIDSMFVNSGDYDLLKNYLLKQLKKVYDQVGFKDSQDESEDILVKLK----RADILSMACHLGH 797
            ..:|.:.....:|::...|:|||:...|.::|:..:......:....:    |.:::.:||..|:
Human   807 YPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGN 871

  Fly   798 QECIAEASRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQYGTEYEWDFAFERFLKTNVPGEKDL 862
            :.|..:||....:|:.:    :.|.|..|:|.:|||:.:....|..|:|.:.:|..|....||.:
Human   872 KHCHQQASTLISDWISS----NRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKI 932

  Fly   863 LLNALGCSKEPWLLYRFLRRGISGQHIRKQDLFRVFAAVSTTVVGQNIAFDFLRNNWQEIKTYMG 927
            ||.||.||.:..||.|.|...::.:.:..||...|...|:....|:::|:.|.|:.|:.:.|..|
Human   933 LLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYG 997

  Fly   928 SQMSSIHTLFKFATKGFNSKFQLGEFENFVKDAHWDYD----RPVQQIVEHIETSVDWMNKNYKS 988
            ..:.....|....|:..|::.:|.|.:||:|    :||    ....:.||.:|.:|.|.......
Human   998 EALFMNSKLISGVTEFLNTEGELKELKNFMK----NYDGVAAASFSRAVETVEANVRWKMLYQDE 1058

  Fly   989 IVRWL 993
            :.:||
Human  1059 LFQWL 1063

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	155/406 (38%)
		M1_APN_2	121..576	CDD:189008	181/469 (39%)
		ERAP1_C	652..974	CDD:288671	98/329 (30%)
TRHDE	NP_037513.2	M1_APN-Q_like	193..638	CDD:341064	177/464 (38%)
		ERAP1_C	723..1047	CDD:403137	100/333 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920