Protein Alignment superdeath and ANPEP

DIOPT Version :10

• Sequence 1: NP_651674.3
• Gene: superdeath / 43444
• FlyBaseID: FBgn0039640
• Length: 999
• Species: Drosophila melanogaster
• Sequence 2: NP_001141.2
• Gene: ANPEP / 290
• HGNCID: 500
• Length: 967
• Species: Homo sapiens
• Alignment Length: 982
• Identity: 359/982 - (36%)
• Similarity: 550/982 - (56%)
• Gaps: 72/982 - (7%)

  Fly    54 ILLASFFICTLLAVGFIVY--------NFATCAELEPDSDEDVVCTSYHLRRLKAGHDDTPKYDR 110
            |||....:||::|:. :||        |.:..|...|.:.......|      ....|.:..::|
Human    16 ILLGVAAVCTIIALS-VVYSQEKNKNANSSPVASTTPSASATTNPAS------ATTLDQSKAWNR 73

  Fly   111 DVRLPHSIRPLKYNITIEPQLSGN----FTFAGSVQIRIRVLEDCYNITMHAEELNISRSDASVH 171
             .|||::::|..|.:|:.|.|:.|    :.|.||..:|....|....|.:|:::||.:.|..  |
Human    74 -YRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQG--H 135

  Fly   172 RVQNNGEPEGDGLRIHKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQGFYRSSYEV 236
            ||...|........|.|..||...::.|:.|...|:||.:|.:...|:|.:.|.|.|||||.|..
Human   136 RVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYME 200

  Fly   237 HNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNM-PIVSSNDHATMPSYV 300
            .|..:.||:||.||.|||::||||||||:||.|.:.:..|:::|.:||| |...|......|::.
Human   201 GNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNWN 265

  Fly   301 WDHFAESLPMSTYLVAYAISDFTHI----SSG-NFAVWARADAIKS--AEYALSVGPRILTFLQD 358
            ...|..:..|||||:|:.:|:|.::    |:| ...:|||..||.:  .:|||:|...||.|...
Human   266 VTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFFAG 330

  Fly   359 FFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQWF 423
            .::..:||||.|.|.||:|.|||||||||:|:||.::|:||..::::||:||.:|:.||||||||
Human   331 HYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWF 395

  Fly   424 GNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDALSTSHKIS---H 485
            |||||..||:|:|||||||||:|||.||...|.|...|..|:|::..|..:|||::||.:|   .
Human   396 GNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPAS 460

  Fly   486 EVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLWHFLTVEA 550
            |:..|.:|||:||.|||:||::::||::.||:..:|::||:.||...||.:....:||..|. ||
Human   461 EINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQ-EA 524

  Fly   551 KSSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVY---TNTTREDE-SLLWY 611
            .::..:....:|::||:.||||.|:||:.|.....:    |.|..|:.   :|.||..| :.:|.
Human   525 VNNRSIQLPTTVRDIMNRWTLQMGFPVITVDTSTGT----LSQEHFLLDPDSNVTRPSEFNYVWI 585

  Fly   612 IPITFTTDSELNFANTRPTTWM----PRTKLYELENRELSLAKWFIFNVQQTGYYRVNYDLENWM 672
            :|||...|     ...:...|:    .:..|:.....|     |.:.|:..|||||||||.|||.
Human   586 VPITSIRD-----GRQQQDYWLIDVRAQNDLFSTSGNE-----WVLLNLNVTGYYRVNYDEENWR 640

  Fly   673 AITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAISNFI 737
            .|...|.  .:...|...||||:|:|..|||....:....|:|.|.:|..|..::||:||:|:..
Human   641 KIQTQLQ--RDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLS 703

  Fly   738 FIDSMFVNSGDYDLLKNYLLKQLKKVYDQVGFKDS----QDESEDILVKLKRADILSMACHLGHQ 798
            :...||..|..|..:||||.||:..::  :.|:::    ::..|:::.:....:.:|.||..|..
Human   704 YFKLMFDRSEVYGPMKNYLKKQVTPLF--IHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVP 766

  Fly   799 ECIAEASRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQYGTEYEWDFAFERFLKTNVPGEKDLL 863
            ||....|..|:.||:.||   ||||.||||..|||:||..|.|.|||||:|:|....:..|.|.|
Human   767 ECEEMVSGLFKQWMENPN---NNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKL 828

  Fly   864 LNALGCSKEPWLLYRFLRRGISGQHIRKQDLFRVFAAVSTTVVGQNIAFDFLRNNWQEIKTYMGS 928
            ..||.||||.|:|.|:|...::...|||||......:::..|:||.:.:||:::||:::....|.
Human   829 RAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGG 893

  Fly   929 QMSSIHTLFKFATKGFNSKFQLGEFENFVKD----AHWDYDRPVQQIVEHIETSVDWMNKNYKSI 989
            ...|...|.:..|:.|:::::|.:.|.|.||    ......|.::|.:|..:.::.|:.:|.:.:
Human   894 GSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVV 958

  Fly   990 VRWL-EN 995
            ::|. ||
Human   959 LQWFTEN 965

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
superdeath	NP_651674.3	M1_APN-Q_like	121..571	CDD:341064	194/464 (42%)
		ERAP1_C	651..976	CDD:463368	120/332 (36%)
ANPEP	NP_001141.2	Cytosolic Ser/Thr-rich junction	33..68		6/40 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	40..62		4/27 (15%)
		Metalloprotease	69..967		346/922 (38%)
		M1_APN-Q_like	84..545	CDD:341064	194/463 (42%)
		Necessary and sufficient to mediate interaction with HCoV-229E. /evidence=ECO:0000269|PubMed:1350662, ECO:0000269|PubMed:8887485	288..295		0/6 (0%)
		ERAP1_C	619..946	CDD:463368	120/333 (36%)