DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and ANPEP

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_001141.2	Gene:	ANPEP / 290	HGNCID:	500	Length:	967	Species:	Homo sapiens

Alignment Length:	982	Identity:	359/982 - (36%)
Similarity:	550/982 - (56%)	Gaps:	72/982 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 ILLASFFICTLLAVGFIVY--------NFATCAELEPDSDEDVVCTSYHLRRLKAGHDDTPKYDR 110
            |||....:||::|:. :||        |.:..|...|.:.......|      ....|.:..::|
Human    16 ILLGVAAVCTIIALS-VVYSQEKNKNANSSPVASTTPSASATTNPAS------ATTLDQSKAWNR 73

  Fly   111 DVRLPHSIRPLKYNITIEPQLSGN----FTFAGSVQIRIRVLEDCYNITMHAEELNISRSDASVH 171
             .|||::::|..|.:|:.|.|:.|    :.|.||..:|....|....|.:|:::||.:.|..  |
Human    74 -YRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQG--H 135

  Fly   172 RVQNNGEPEGDGLRIHKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQGFYRSSYEV 236
            ||...|........|.|..||...::.|:.|...|:||.:|.:...|:|.:.|.|.|||||.|..
Human   136 RVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYME 200

  Fly   237 HNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNM-PIVSSNDHATMPSYV 300
            .|..:.||:||.||.|||::||||||||:||.|.:.:..|:::|.:||| |...|......|::.
Human   201 GNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNWN 265

  Fly   301 WDHFAESLPMSTYLVAYAISDFTHI----SSG-NFAVWARADAIKS--AEYALSVGPRILTFLQD 358
            ...|..:..|||||:|:.:|:|.::    |:| ...:|||..||.:  .:|||:|...||.|...
Human   266 VTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFFAG 330

  Fly   359 FFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQWF 423
            .::..:||||.|.|.||:|.|||||||||:|:||.::|:||..::::||:||.:|:.||||||||
Human   331 HYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWF 395

  Fly   424 GNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDALSTSHKIS---H 485
            |||||..||:|:|||||||||:|||.||...|.|...|..|:|::..|..:|||::||.:|   .
Human   396 GNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPAS 460

  Fly   486 EVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLWHFLTVEA 550
            |:..|.:|||:||.|||:||::::||::.||:..:|::||:.||...||.:....:||..|. ||
Human   461 EINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQ-EA 524

  Fly   551 KSSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVY---TNTTREDE-SLLWY 611
            .::..:....:|::||:.||||.|:||:.|.....:    |.|..|:.   :|.||..| :.:|.
Human   525 VNNRSIQLPTTVRDIMNRWTLQMGFPVITVDTSTGT----LSQEHFLLDPDSNVTRPSEFNYVWI 585

  Fly   612 IPITFTTDSELNFANTRPTTWM----PRTKLYELENRELSLAKWFIFNVQQTGYYRVNYDLENWM 672
            :|||...|     ...:...|:    .:..|:.....|     |.:.|:..|||||||||.|||.
Human   586 VPITSIRD-----GRQQQDYWLIDVRAQNDLFSTSGNE-----WVLLNLNVTGYYRVNYDEENWR 640

  Fly   673 AITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAISNFI 737
            .|...|.  .:...|...||||:|:|..|||....:....|:|.|.:|..|..::||:||:|:..
Human   641 KIQTQLQ--RDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLS 703

  Fly   738 FIDSMFVNSGDYDLLKNYLLKQLKKVYDQVGFKDS----QDESEDILVKLKRADILSMACHLGHQ 798
            :...||..|..|..:||||.||:..::  :.|:::    ::..|:::.:....:.:|.||..|..
Human   704 YFKLMFDRSEVYGPMKNYLKKQVTPLF--IHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVP 766

  Fly   799 ECIAEASRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQYGTEYEWDFAFERFLKTNVPGEKDLL 863
            ||....|..|:.||:.||   ||||.||||..|||:||..|.|.|||||:|:|....:..|.|.|
Human   767 ECEEMVSGLFKQWMENPN---NNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKL 828

  Fly   864 LNALGCSKEPWLLYRFLRRGISGQHIRKQDLFRVFAAVSTTVVGQNIAFDFLRNNWQEIKTYMGS 928
            ..||.||||.|:|.|:|...::...|||||......:::..|:||.:.:||:::||:::....|.
Human   829 RAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGG 893

  Fly   929 QMSSIHTLFKFATKGFNSKFQLGEFENFVKD----AHWDYDRPVQQIVEHIETSVDWMNKNYKSI 989
            ...|...|.:..|:.|:::::|.:.|.|.||    ......|.::|.:|..:.::.|:.:|.:.:
Human   894 GSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVV 958

  Fly   990 VRWL-EN 995
            ::|. ||
Human   959 LQWFTEN 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	176/406 (43%)
		M1_APN_2	121..576	CDD:189008	198/469 (42%)
		ERAP1_C	652..974	CDD:288671	118/329 (36%)
ANPEP	NP_001141.2	Cytosolic Ser/Thr-rich junction	33..68		6/40 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..62		4/27 (15%)
		Metalloprotease	69..967		346/922 (38%)
		M1_APN-Q_like	84..545	CDD:341064	194/463 (42%)
		Necessary and sufficient to mediate interaction with HCoV-229E. /evidence=ECO:0000269\|PubMed:1350662, ECO:0000269\|PubMed:8887485	288..295		0/6 (0%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:22932899	352..356		3/3 (100%)
		ERAP1_C	619..946	CDD:403137	120/333 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	237	1.000	Domainoid score	I2322
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68163
Inparanoid	1	1.050	608	1.000	Inparanoid score	I931
Isobase	1	0.950	-	0	Normalized mean entropy	S2057
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm40365
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3793
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.850