DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and Lnpep

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_766415.1	Gene:	Lnpep / 240028	MGIID:	2387123	Length:	1025	Species:	Mus musculus

Alignment Length:	1000	Identity:	312/1000 - (31%)
Similarity:	508/1000 - (50%)	Gaps:	111/1000 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SKGGRRYS----VSLTTA--ILLASFFICTLLAVGFIVYNFATC-------------AEL-EPDS 84
            |..|.|.|    .||.:|  :::..|.|...::|..::|....|             ||| :|.:
Mouse    91 SAAGYRQSPDGTCSLPSARTLVICVFVIVVAVSVIMVIYLLPRCTFTKEGCHKTNQSAELIQPVA 155

  Fly    85 DEDVVCTSYHLRRLKAGHDDTPKYDRDVRLPHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLE 149
            ....|...                 ..:|||.:|.||.|.:::.|.|: :.||.|||.|.::.|:
Mouse   156 TNGKVFPW-----------------AQIRLPTAIIPLCYELSLHPNLT-SMTFRGSVTISLQALQ 202

  Fly   150 DCYNITMHAEELNISRSDASVHRVQNNGEPEGDGLR--IHKQYLVGAKQFFVIELYDKLLKDVEY 212
            |..:|.:|:...||||  .:.....::.|.:.:.|.  .|:|..|.|.        :.||....|
Mouse   203 DTRDIILHSTGHNISR--VTFMSAVSSQEKQVEILEYPYHEQIAVVAP--------EPLLTGHNY 257

  Fly   213 VVHLRFDGIIEDYLQGFYRSSY-EVHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARP 276
            .:.:.:...|.:...|||..:| :..||.::.|:|||:...||.|||||||||.||.|.:.|.|.
Mouse   258 TLKIEYSANISNSYYGFYGITYTDKSNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKITRN 322

  Fly   277 RNMTTISNMPIVSSNDHATMPS---YVWDHFAESLPMSTYLVAYAISDFTHIS---SGNF-AVWA 334
            .:.|.:||||..||     :|:   .:.|.|:||:.|||||||:.:.:..::|   :|.. :|:|
Mouse   323 EHHTALSNMPKKSS-----VPAEEGLIQDEFSESVKMSTYLVAFIVGEMRNLSQDVNGTLVSVYA 382

  Fly   335 RADAIKSAEYALSVGPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDP 399
            ..:.|....:||....::|.|.|.:|.:.:||.|:|::|:|:|:|||||||||:||||..:|||.
Mouse   383 VPEKIGQVHHALDTTIKLLEFYQTYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDN 447

  Fly   400 GVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFV 464
            ..::..:::.|..::.|||||||||||||..||:|:|||||||::|||.:.:.:..|....:.|
Mouse   448 ATSSVADRKLVTKIIAHELAHQWFGNLVTMQWWNDLWLNEGFATFMEYFSVEKIFKELNSYEDF- 511

  Fly   465 VNELQAVFQL---DALSTSHKISHEVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLS 526
               |.|.|:.   |:|::||.||..|.:.::|.|:||.:||.||::::.|:..:|:..:||..:.
Mouse   512 ---LDARFKTMRKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGASLLLMLKSYLSEDVFRHAVI 573

  Fly   527 KYLQEMAYNSATQDDLWHFLTVEAKSSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRL 591
            .||...:|.:...||||.      ..:.:.|.:..||::|.|||||.|:|:|.|.|  ....:.|
Mouse   574 LYLHNHSYAAIQSDDLWD------SFNEVTDKTLDVKKMMKTWTLQKGFPLVTVQR--KGTELLL 630

  Fly   592 EQVRF---VYTNTTREDESLLWYIPITFTTDSELNFANTRPTTWMPRTKLYELENRELSL---AK 650
            :|.||   :...:...|.|.||:|||::.||.. |::..|..:      |.:.::..::|   .:
Mouse   631 QQERFFLRMQPESQPSDTSHLWHIPISYVTDGR-NYSEYRSVS------LLDKKSDVINLTEQVQ 688

  Fly   651 WFIFNVQQTGYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMN 715
            |...|...||||.|:|..::|.|:...|.  .|...::..:||.||:::..||....:....|.:
Mouse   689 WVKVNSNMTGYYIVHYAHDDWTALINQLK--RNPYVLSDKDRANLINNIFELAGLGKVPLRMAFD 751

  Fly   716 LTRYLGHELGHVPWKAAISNFIFIDSMFVNSGDYDLLKNYLLKQLKKVYDQVGFKDSQDESEDIL 780
            |..||.:|....|...|:.....|.::....|..||....:.:..|.:.:|:..:...||....:
Mouse   752 LIDYLKNETHTAPITEALFQTNLIYNLLEKLGHMDLSSRLVARVHKLLQNQIQQQTWTDEGTPSM 816

  Fly   781 VKLKRADILSMACHLGHQECIAEASRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQYG--TEYE 843
            .:|:.| :|..||....:.|...|:..|.:||.:....|       |...|..:..:.|  ||..
Mouse   817 RELRSA-LLEFACAHSLENCTTMATNLFDSWMASNGTQS-------LPTDVMVTVFKVGARTEKG 873

  Fly   844 WDFAFERFLKTNVPGEKDLLLNALGCSKEPWLLYRFLRRGISGQHIRKQDLFRVFAAVSTTVVGQ 908
            |.|.|..:.......||:.:|.||..|::...||..::..:.|..||.|.|..:...|.....|.
Mouse   874 WLFLFSMYSSMGSEAEKNKILEALASSEDVHKLYWLMKSSLDGDIIRTQKLSLIIRTVGRHFPGH 938

  Fly   909 NIAFDFLRNNWQEI--KTYMGSQMSSIHTLFKFATKGFNSKFQLGEFENFVK---DAHWDYDRPV 968
            .:|:||::.||.::  |.::||.  :|.::...:|..|::|..|.|.:.|.:   :|.... |.|
Mouse   939 LLAWDFVKENWNKLVHKFHLGSY--TIQSIVAGSTHLFSTKTHLSEVQAFFENQSEATLKL-RCV 1000

  Fly   969 QQIVEHIETSVDWMNKNYKSIVRWL 993
            |:.:|.|:.::.||.:|.|::.:||
Mouse  1001 QEALEVIQLNIQWMVRNLKTLSQWL 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	157/404 (39%)
		M1_APN_2	121..576	CDD:189008	175/467 (37%)
		ERAP1_C	652..974	CDD:288671	85/328 (26%)
Lnpep	NP_766415.1	Dileucine internalization motif. /evidence=ECO:0000255	53..54
		Dileucine internalization motif. /evidence=ECO:0000255	76..77
		Tankyrase binding. /evidence=ECO:0000250	96..101		2/4 (50%)
		Peptidase_M1	167..552	CDD:279741	157/404 (39%)
		M1_APN_2	177..617	CDD:189008	174/465 (37%)
		Substrate binding. /evidence=ECO:0000250	428..432		3/3 (100%)
		ERAP1_C	690..1005	CDD:288671	85/327 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.820