DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and Trhde

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_666353.2	Gene:	Trhde / 237553	MGIID:	2384311	Length:	1066	Species:	Mus musculus

Alignment Length:	1029	Identity:	322/1029 - (31%)
Similarity:	517/1029 - (50%)	Gaps:	104/1029 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PTTTTTFSKGGRRYSVSLTTAILLASFFICTLLAVGFIVYNFATCAELE------------PDSD 85
            |.||.......:|  :.|..|:.:.:....|:||| .:...|..|....            |:.|
Mouse    68 PRTTERHIAVHKR--LVLAFAVSIVALLAVTMLAV-LLSLRFDECGASAAMPGTDGGLGGFPERD 129

  Fly    86 EDVVCTSYHLRRLKAGHDDTPKYDRDV-------------------------RLPHSIRPLKYNI 125
            .:........|...||.:.:.:...:|                         ||...::||.||:
Mouse   130 SNSSFPGSARRNHHAGGESSQRESGEVGTPGTPSAQPPSEEEREQWQPWTQLRLSGHLKPLHYNL 194

  Fly   126 TIEPQLSGNFTFAGSVQIRIRVLEDCYNIT----MHAEELNISRSDASVHRVQNNGEPEGDGLRI 186
            .:...:. ||||:|.|.:.|.    |.|.|    :||       |..:|.:||...:.....:.:
Mouse   195 MLTAFME-NFTFSGEVNVEIA----CRNATRYVVLHA-------SRVAVEKVQVAEDRAFGAVPV 247

  Fly   187 HKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQGFYRSSYEVHNETRWVASTQFQAT 251
            ...:|....|..|:.|...|.....|.:.:.::.:||:.|.||:||||.:|.|.|::..|||..|
Mouse   248 AGFFLYPQTQVLVVVLNRTLDAQRHYNLKIIYNALIENELLGFFRSSYVIHGERRFLGVTQFSPT 312

  Fly   252 DARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSS---NDHATMPSYVWDHFAESLPMSTY 313
            .||:||||||||..||.|.:.|.......::||||:.:|   .|     .:|.|||:::..||||
Mouse   313 HARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEED-----GWVTDHFSQTPLMSTY 372

  Fly   314 LVAYAISDFTH----ISSGNFA-VWARADAIK--SAEYALSVGPRILTFLQDFFNVTFPLPKIDM 371
            .:|:||.:||:    ..||... ::||.|||:  |.:|||.:..|::.|.:|:|.|.:.|||:|:
Mouse   373 YLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDL 437

  Fly   372 IALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIW 436
            :|:|:....|||||||..|.|..:|.||.|::.:....|..|:.||:.|||||:||||.||.|:|
Mouse   438 LAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVW 502

  Fly   437 LNEGFASYMEYLTADAVAPEWK-QLDQFVVNELQAVFQLDALSTSHKISHEVFNPQEISEIFDRI 500
            |.||||.|.|::..|.:.|.|. :..:|:.:.|..|..||.|::||.:|.||....:|..:||.|
Mouse   503 LKEGFAHYFEFVGTDYLYPAWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLRATDIDRVFDWI 567

  Fly   501 SYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLWHFLTVEAKSSGLLDDSRSVKEI 565
            :|.||:.:|||:|:|:.:.:|:|||..||....|.:|.::|||:.|:...:.:|   ...:::|:
Mouse   568 AYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALRRNG---KYVNIQEV 629

  Fly   566 MDTWTLQTGYPVVKVSRHPNSD-VIRLEQVRFVYTNTTR------EDESLLWYIPITFTTDSELN 623
            ||.||||.||||:.:..:..:: .|.:.|..|:|....:      ::.|.||.||:|....:. :
Mouse   630 MDQWTLQMGYPVITILGNTTAENRILITQQHFIYDIGAKTKALQLQNSSYLWQIPLTIVVGNR-S 693

  Fly   624 FANTRPTTWMPRTKLYELENRE---LSLAKWFIFNVQQTGYYRVNYDLENWMAITEHLMDVDNFE 685
            ..::....|:..    :.|:..   |....|.:.|:.||||:||||||.||..:.:.|  :.|.|
Mouse   694 HVSSEAIIWVSN----KSEHHRIAYLDRGSWILGNINQTGYFRVNYDLRNWRLLIDQL--IRNHE 752

  Fly   686 DIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAISNFIFIDSMFVNSGDYD 750
            .::.:|||.||||..:|||..||.....:.:.|||..|...:||.||......:|.:.....:|:
Mouse   753 VLSVSNRAALIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYN 817

  Fly   751 LLKNYLLKQLKKVYDQVGFKDSQDESEDILVKLK------RADILSMACHLGHQECIAEASRHFQ 809
            :...|:|||:...|.::|:  .::.....||:..      |.:::.:||..|::.|..:||....
Mouse   818 IFNEYILKQVATTYIKLGW--PRNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLIS 880

  Fly   810 NWMQTPNPDSNNPIVPNLRGVVYCSAIQYGTEYEWDFAFERFLKTNVPGEKDLLLNALGCSKEPW 874
            :|:.:    :.|.|..|:|.:|||:.:....|..|:|.:.:|..|....||.:||.||.||.:..
Mouse   881 DWISS----NRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRN 941

  Fly   875 LLYRFLRRGISGQHIRKQDLFRVFAAVSTTVVGQNIAFDFLRNNWQEIKTYMGSQMSSIHTLFKF 939
            ||.|.|...::.:.:..||...|...|:....|:::|:.|.|:.|:.:.|..|..:.....|...
Mouse   942 LLSRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISG 1006

  Fly   940 ATKGFNSKFQLGEFENFVKDAHWDYDRPVQQIVEHIETSVDWMNKNYKSIVRWL 993
            .|:..|::.:|.|.:||:|...........:.||.:|.:|.|.......:.:||
Mouse  1007 VTEFLNTEGELKELKNFMKSYDGVASASFSRAVETVEANVRWKRFYQDELFQWL 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	155/406 (38%)
		M1_APN_2	121..576	CDD:189008	180/469 (38%)
		ERAP1_C	652..974	CDD:288671	98/327 (30%)
Trhde	NP_666353.2	M1_APN-Q_like	190..635	CDD:341064	176/464 (38%)
Trhde	NP_666353.2	ERAP1_C	720..1044	CDD:378732	100/331 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020