DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14516 and Rnpep

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_663392.2	Gene:	Rnpep / 215615	MGIID:	2384902	Length:	650	Species:	Mus musculus

Alignment Length:	435	Identity:	112/435 - (25%)
Similarity:	173/435 - (39%)	Gaps:	106/435 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 TQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSSNDHATMPSYVWD-------H 303
            ||.||...|..|||||.||:|..::..|..|...|             |.|.:..|:       .
Mouse   168 TQGQAVLNRAFFPCFDTPAVKCTYSALIEVPDGFT-------------AVMSADTWEKRGPNKFF 219

  Fly   304 FAESLPMSTYLVAYAISDFTHISSG-NFAVWARADAIKSA--EYA------LSVGPRIL-TFLQD 358
            |..|.|:.:||:|.||.|......| ...|||....|::|  ||:      |:.|.::. .::..
Mouse   220 FQMSHPIPSYLIALAIGDLASAEVGPRSRVWAEPCLIEAAKEEYSGVIEEFLATGEKLFGPYVWG 284

  Fly   359 FFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQWF 423
            .:::.| :|       |.|..|.||| ..:||....:|       |.::. :|.|:.||::|.||
Mouse   285 RYDLLF-MP-------PSFPFGGMEN-PCLTFVTPCLL-------AGDRS-LADVIIHEISHSWF 332

  Fly   424 GNLVTPSWWSDIWLNEGFASY----------------MEYLTADAVAPEWKQL--DQFVVNELQA 470
            |||||.:.|.:.||||||..|                :|..|..|:..:...:  ::..:|:|:.
Mouse   333 GNLVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALLRQHMNVSGEENPLNKLRV 397

  Fly   471 VFQLDALSTSHKISHEVFNPQEISEIFDRISYAKGSTIIRMMAHFL-TNPIFRRGLSKYLQEMAY 534
                       ||...|    :..:.::...|.||...:..:||.: ....|.:.|..|:.|..:
Mouse   398 -----------KIEPGV----DPDDTYNETPYEKGYCFVSYLAHLVGDQDQFDKFLKAYVDEFKF 447

  Fly   535 NSATQDDLWHFLT---VEAKSSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRF 596
            .|...:|...|..   .|.|..|:  ||....| .|.|....|:|.......|...:::
Mouse   448 QSILAEDFLEFYLEYFPELKKKGV--DSIPGFE-FDRWLNTPGWPPYLPDLSPGDSLMK------ 503

  Fly   597 VYTNTTREDESLLWYIPITFTTDSELNFANTRPTTWMPRTKLYEL 641
                 ..|:.:.||   :|...|.:...| ...:||    |.|:|
Mouse   504 -----PAEELAELW---VTSEPDMQAIEA-VAISTW----KTYQL 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	79/293 (27%)
		M1_APN_2	121..576	CDD:189008	99/368 (27%)
		ERAP1_C	652..974	CDD:288671
Rnpep	NP_663392.2	leuko_A4_hydro	24..634	CDD:274120	112/435 (26%)
		M1_LTA4H	24..484	CDD:189006	98/363 (27%)
		Substrate binding. /evidence=ECO:0000250	298..302		2/3 (67%)
		Leuk-A4-hydro_C	504..644	CDD:286244	11/40 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810