Protein Alignment superdeath and LVRN

DIOPT Version :10

• Sequence 1: NP_651674.3
• Gene: superdeath / 43444
• FlyBaseID: FBgn0039640
• Length: 999
• Species: Drosophila melanogaster
• Sequence 2: NP_776161.3
• Gene: LVRN / 206338
• HGNCID: 26904
• Length: 990
• Species: Homo sapiens
• Alignment Length: 1020
• Identity: 317/1020 - (31%)
• Similarity: 510/1020 - (50%)
• Gaps: 114/1020 - (11%)

  Fly    46 YSVSLTTAILLASFFICTLLAVGFIVYNFATCAELEPDSD----EDVVCTSYHLRRLKAGHDDTP 106
            :.||...|:|||......|||:..:...:..| |..|.|:    .|:...|....|.|......|
Human     9 FYVSRAVALLLAGLVAALLLALAVLAALYGHC-ERVPPSELPGLRDLEAESSPPLRQKPTPTPKP 72

  Fly   107 KYDRD------------------VRLPHSIRPLKYNITIEPQL------SGNFTFAGSVQIRIR- 146
            ...|:                  :|||..:.||.|::.:.|||      :|:..|.|.|.|.:|
Human    73 SSARELAVTTTPSNWRPPGPWDQLRLPPWLVPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRC 137

  Fly   147 -----------VLEDCYNITMHAEELNISRSDASVHRVQNNGEPEGDGLRIHKQYLVGAKQFFVI 200
                       :.:||....:.. .|:....:|:|.||     |..|      .:.....::.|:
Human   138 TVATSRLLLHSLFQDCERAEVRG-PLSPGTGNATVGRV-----PVDD------VWFALDTEYMVL 190

  Fly   201 ELYDKLLKDVEYVVHLRFDGII-EDYLQGFYRSSYEVHNETRWVASTQFQATDARRAFPCFDEPA 264
            ||.:.|.....|.:.|.|.|:: ||..:|.:.:.|....|.|.:.::|.:.|.||..||||||||
Human   191 ELSEPLKPGSSYELQLSFSGLVKEDLREGLFLNVYTDQGERRALLASQLEPTFARYVFPCFDEPA 255

  Fly   265 LKANFTLHIARPRNMTTISNMPIVSSNDHATMPSYVW--DHFAESLPMSTYLVAYAISDFTHIS- 326
            |||.|.:.:....:...:||||.:..::...:....|  ..|:.:..|.|||||:.|.|:.|::
Human   256 LKATFNITMIHHPSYVALSNMPKLGQSEKEDVNGSKWTVTTFSTTPHMPTYLVAFVICDYDHVNR 320

  Fly   327 ---SGNFAVWARADAIK--SAEYALSVGPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWG 386
               .....:|||.|||.  ||::||::...|.:||:|.||:::.|||.|:||||.|...||||||
Human   321 TERGKEIRIWARKDAIANGSADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENWG 385

  Fly   387 LITFRETAMLYDPGVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTAD 451
            |:.|.|:.:|.:|.......|..::.||.||:.|||||||||.:||::||||||||||.|:...:
Human   386 LMIFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFEVIN 450

  Fly   452 AVAPEWKQLDQFVVNELQAVFQLDALSTSHKISHEV--FNPQEISEIFDRISYAKGSTIIRMMAH 514
            ...|:..:.:.|..|.|..:.:.|....:..::.:|  |...||.|:||..:|:||:::.||::.
Human   451 YFNPKLPRNEIFFSNILHNILREDHALVTRAVAMKVENFKTSEIQELFDIFTYSKGASMARMLSC 515

  Fly   515 FLTNPIFRRGLSKYLQEMAYNSATQDDLW-HF-LTVEAKSSGLLDDSRSVKEIMDTWTLQTGYPV 577
            ||...:|...|..||:..:|::|.||||| || :.::.:|:.:|  ..::|.|||:||.|:|:||
Human   516 FLNEHLFVSALKSYLKTFSYSNAEQDDLWRHFQMAIDDQSTVIL--PATIKNIMDSWTHQSGFPV 578

  Fly   578 VKVSRHPNSDVIR-----LEQVRFVYTNTTREDESLLWYIPITFTTDSELNFANTRPTTWMPR-T 636
            :.:  :.::.|::     ||.::    |.|....:..|.:||.:     :....|:|..|:.: :
Human   579 ITL--NVSTGVMKQEPFYLENIK----NRTLLTSNDTWIVPILW-----IKNGTTQPLVWLDQSS 632

  Fly   637 KLYELENRELSLAKWFIFNVQQTGYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLIDDVMN 701
            |::.......|...|.|.|:..|||||||||...|..:.:.| :.|. :.|...:|.|||||..:
Human   633 KVFPEMQVSDSDHDWVILNLNMTGYYRVNYDKLGWKKLNQQL-EKDP-KAIPVIHRLQLIDDAFS 695

  Fly   702 LARGSYLSYETAMNLTRYLGHELGHVPWKAAISNFIFIDSMF-VNSGD-YDLLKNYLLKQLK--- 761
            |::.:|:..|||:.||:||..|...:.|...:.|.:..|.:. ||..| |.|||.||||:|.
Human   696 LSKNNYIEIETALELTKYLAEEDEIIVWHTVLVNLVTRDLVSEVNIYDIYSLLKRYLLKRLNLIW 760

  Fly   762 KVYDQVGFKDSQDESEDILVKLKRADILSMACHLGHQECIAEASRHFQNWMQTPNPDSNNPIVPN 826
            .:|..:..::.....:|.|..:....:...||.||.::|:..:...|..|:..|..:...||
Human   761 NIYSTIIRENVLALQDDYLALISLEKLFVTACWLGLEDCLQLSKELFAKWVDHPENEIPYPI--- 822

  Fly   827 LRGVVYCSAIQYGTEYEWDFAFERFLKTNVPGEKDLLLNALGCSKEPWLLYRFLRRGISGQHIRK 891
             :.||.|..|..|::.|||.....:..|....||..|..|:.|||:||:|.|::...||......
Human   823 -KDVVLCYGIALGSDKEWDILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPFTS 886

  Fly   892 QDLFRVFAAVSTTVVGQNIAFDFLRNNWQEIKTYMGSQ--MSSIHTLFKFATKGFNSKFQLGEFE 954
            .:. .:...|:::.||:.:|.|||.||||.:....|:|  ::.|:|:.:..|    :..|:.|.:
Human   887 NET-NIIEVVASSEVGRYVAKDFLVNNWQAVSKRYGTQSLINLIYTIGRTVT----TDLQIVELQ 946

  Fly   955 NFVKDAHWDYDRPVQQIVEHIETSVDWMNKNYKS------IVRWL 993
            .|..:...::.|  .::..:::|.   .|:|.|:      |..||
Human   947 QFFSNMLEEHQR--IRVHANLQTI---KNENLKNKKLSARIAAWL 986

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
superdeath	NP_651674.3	M1_APN-Q_like	121..571	CDD:341064	167/480 (35%)
		ERAP1_C	651..976	CDD:463368	102/331 (31%)
LVRN	NP_776161.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	48..91		6/42 (14%)
		M1_APN-Q_like	105..572	CDD:341064	167/480 (35%)
		ERAP1_C	647..970	CDD:463368	103/338 (30%)