DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and LVRN

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_776161.3	Gene:	LVRN / 206338	HGNCID:	26904	Length:	990	Species:	Homo sapiens

Alignment Length:	1020	Identity:	317/1020 - (31%)
Similarity:	510/1020 - (50%)	Gaps:	114/1020 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 YSVSLTTAILLASFFICTLLAVGFIVYNFATCAELEPDSD----EDVVCTSYHLRRLKAGHDDTP 106
            :.||...|:|||......|||:..:...:..| |..|.|:    .|:...|....|.|......|
Human     9 FYVSRAVALLLAGLVAALLLALAVLAALYGHC-ERVPPSELPGLRDLEAESSPPLRQKPTPTPKP 72

  Fly   107 KYDRD------------------VRLPHSIRPLKYNITIEPQL------SGNFTFAGSVQIRIR- 146
            ...|:                  :|||..:.||.|::.:.|||      :|:..|.|.|.|.:|
Human    73 SSARELAVTTTPSNWRPPGPWDQLRLPPWLVPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRC 137

  Fly   147 -----------VLEDCYNITMHAEELNISRSDASVHRVQNNGEPEGDGLRIHKQYLVGAKQFFVI 200
                       :.:||....:.. .|:....:|:|.||     |..|      .:.....::.|:
Human   138 TVATSRLLLHSLFQDCERAEVRG-PLSPGTGNATVGRV-----PVDD------VWFALDTEYMVL 190

  Fly   201 ELYDKLLKDVEYVVHLRFDGII-EDYLQGFYRSSYEVHNETRWVASTQFQATDARRAFPCFDEPA 264
            ||.:.|.....|.:.|.|.|:: ||..:|.:.:.|....|.|.:.::|.:.|.||..||||||||
Human   191 ELSEPLKPGSSYELQLSFSGLVKEDLREGLFLNVYTDQGERRALLASQLEPTFARYVFPCFDEPA 255

  Fly   265 LKANFTLHIARPRNMTTISNMPIVSSNDHATMPSYVW--DHFAESLPMSTYLVAYAISDFTHIS- 326
            |||.|.:.:....:...:||||.:..::...:....|  ..|:.:..|.|||||:.|.|:.|::
Human   256 LKATFNITMIHHPSYVALSNMPKLGQSEKEDVNGSKWTVTTFSTTPHMPTYLVAFVICDYDHVNR 320

  Fly   327 ---SGNFAVWARADAIK--SAEYALSVGPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWG 386
               .....:|||.|||.  ||::||::...|.:||:|.||:::.|||.|:||||.|...||||||
Human   321 TERGKEIRIWARKDAIANGSADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENWG 385

  Fly   387 LITFRETAMLYDPGVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTAD 451
            |:.|.|:.:|.:|.......|..::.||.||:.|||||||||.:||::||||||||||.|:...:
Human   386 LMIFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFEVIN 450

  Fly   452 AVAPEWKQLDQFVVNELQAVFQLDALSTSHKISHEV--FNPQEISEIFDRISYAKGSTIIRMMAH 514
            ...|:..:.:.|..|.|..:.:.|....:..::.:|  |...||.|:||..:|:||:::.||::.
Human   451 YFNPKLPRNEIFFSNILHNILREDHALVTRAVAMKVENFKTSEIQELFDIFTYSKGASMARMLSC 515

  Fly   515 FLTNPIFRRGLSKYLQEMAYNSATQDDLW-HF-LTVEAKSSGLLDDSRSVKEIMDTWTLQTGYPV 577
            ||...:|...|..||:..:|::|.||||| || :.::.:|:.:|  ..::|.|||:||.|:|:||
Human   516 FLNEHLFVSALKSYLKTFSYSNAEQDDLWRHFQMAIDDQSTVIL--PATIKNIMDSWTHQSGFPV 578

  Fly   578 VKVSRHPNSDVIR-----LEQVRFVYTNTTREDESLLWYIPITFTTDSELNFANTRPTTWMPR-T 636
            :.:  :.::.|::     ||.::    |.|....:..|.:||.:     :....|:|..|:.: :
Human   579 ITL--NVSTGVMKQEPFYLENIK----NRTLLTSNDTWIVPILW-----IKNGTTQPLVWLDQSS 632

  Fly   637 KLYELENRELSLAKWFIFNVQQTGYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLIDDVMN 701
            |::.......|...|.|.|:..|||||||||...|..:.:.| :.|. :.|...:|.|||||..:
Human   633 KVFPEMQVSDSDHDWVILNLNMTGYYRVNYDKLGWKKLNQQL-EKDP-KAIPVIHRLQLIDDAFS 695

  Fly   702 LARGSYLSYETAMNLTRYLGHELGHVPWKAAISNFIFIDSMF-VNSGD-YDLLKNYLLKQLK--- 761
            |::.:|:..|||:.||:||..|...:.|...:.|.:..|.:. ||..| |.|||.||||:|.
Human   696 LSKNNYIEIETALELTKYLAEEDEIIVWHTVLVNLVTRDLVSEVNIYDIYSLLKRYLLKRLNLIW 760

  Fly   762 KVYDQVGFKDSQDESEDILVKLKRADILSMACHLGHQECIAEASRHFQNWMQTPNPDSNNPIVPN 826
            .:|..:..::.....:|.|..:....:...||.||.::|:..:...|..|:..|..:...||
Human   761 NIYSTIIRENVLALQDDYLALISLEKLFVTACWLGLEDCLQLSKELFAKWVDHPENEIPYPI--- 822

  Fly   827 LRGVVYCSAIQYGTEYEWDFAFERFLKTNVPGEKDLLLNALGCSKEPWLLYRFLRRGISGQHIRK 891
             :.||.|..|..|::.|||.....:..|....||..|..|:.|||:||:|.|::...||......
Human   823 -KDVVLCYGIALGSDKEWDILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPFTS 886

  Fly   892 QDLFRVFAAVSTTVVGQNIAFDFLRNNWQEIKTYMGSQ--MSSIHTLFKFATKGFNSKFQLGEFE 954
            .:. .:...|:::.||:.:|.|||.||||.:....|:|  ::.|:|:.:..|    :..|:.|.:
Human   887 NET-NIIEVVASSEVGRYVAKDFLVNNWQAVSKRYGTQSLINLIYTIGRTVT----TDLQIVELQ 946

  Fly   955 NFVKDAHWDYDRPVQQIVEHIETSVDWMNKNYKS------IVRWL 993
            .|..:...::.|  .::..:::|.   .|:|.|:      |..||
Human   947 QFFSNMLEEHQR--IRVHANLQTI---KNENLKNKKLSARIAAWL 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	145/420 (35%)
		M1_APN_2	121..576	CDD:189008	170/485 (35%)
		ERAP1_C	652..974	CDD:288671	101/328 (31%)
LVRN	NP_776161.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..91		6/42 (14%)
		Peptidase_M1	97..506	CDD:279741	145/420 (35%)
		M1_APN_2	105..577	CDD:189008	170/485 (35%)
		Substrate binding. /evidence=ECO:0000250	379..383		2/3 (67%)
		ERAP1_C	648..951	CDD:288671	100/313 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155414
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750