Protein Alignment superdeath and ENPEP

DIOPT Version :10

• Sequence 1: NP_651674.3
• Gene: superdeath / 43444
• FlyBaseID: FBgn0039640
• Length: 999
• Species: Drosophila melanogaster
• Sequence 2: NP_001968.3
• Gene: ENPEP / 2028
• HGNCID: 3355
• Length: 957
• Species: Homo sapiens
• Alignment Length: 1010
• Identity: 318/1010 - (31%)
• Similarity: 523/1010 - (51%)
• Gaps: 119/1010 - (11%)

  Fly    41 KGGRRYSVSLTTAILLASFFICTLLAVGFIVYNFATCAELEPDSDEDVVCTSYHLRRLKAGHDDT 105
            :|.:||.:......:|.:..:...|.||..|....:| :...|..........||....|.....
Human     7 EGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSC-DSSGDGGPGTAPAPSHLPSSTASPSGP 70

  Fly   106 PKYDRDV--------------RLPHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLEDCYNITM 156
            |..|:|:              |||..:.|:.|::.::|.|..: |:.|:|.|.|.:......:.:
Human    71 PAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEED-TYTGTVSISINLSAPTRYLWL 134

  Fly   157 HAEELNISRSDASVHRVQNNGEPEGDGLRIHKQYLVGAKQFFVIELYDKLLK---DVEYVVHLRF 218
            |..|..|:       |:.....|.||.:::.:.:....:::.|:|..::|..   |..|::.:.|
Human   135 HLRETRIT-------RLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEF 192

  Fly   219 DGIIEDYLQGFYRSSYEVHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTIS 283
            .|.:...|.||||::|..:.:.:.:.:|..:.||||::|||||||..||.:|:.|..|:....:|
Human   193 AGWLNGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALS 257

  Fly   284 NMPIV---SSNDHATMPSYVWDHFAESLPMSTYLVAYAISDFTHI----SSGN-FAVWARADAIK 340
            |||:.   |.:|..|..:     |.:|:|||||||.:|:..|..:    :||. ..::.:.:...
Human   258 NMPVAKEESVDDKWTRTT-----FEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKH 317

  Fly   341 SAEYALSVGPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATAN 405
            :||||.::...:..:.:::|.:.:.|||:|.||:|:|..||||||||||:|||.:||||..:.::
Human   318 TAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASS 382

  Fly   406 NKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQA 470
            |:||||:||.|||.||||||:||..||.|:||||||||:.|:|..:....:|:..||.::.::..
Human   383 NQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLP 447

  Fly   471 VFQLDALSTSHKISHEVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYN 535
            |.:.|:|.:||.|...|..|.||:.:||.|||:|||:|:||:..::....|::|...||::..:.
Human   448 VQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFK 512

  Fly   536 SATQDDLWHFLTVEAKSSGLLDDSR-SVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVY- 598
            :|...|.|         :.|.:.|| .|||:|||||.|.||||:.|     :.|..:.|.||:.
Human   513 NAKTSDFW---------AALEEASRLPVKEVMDTWTRQMGYPVLNV-----NGVKNITQKRFLLD 563

  Fly   599 --TNTTR--EDESLLWYIPITFTTDS---------------ELNFANTRPTTWMPRTKLYELENR 644
              .|.::  .|....|.||:.:|.|:               .||.:|.....::.
Human   564 PRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLK---------- 618

  Fly   645 ELSLAKWFIFNVQQTGYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLS 709
                     .|....|:|||||::..|.:|...|.  .|.:..:.|:||.||||...|||...|.
Human   619 ---------INPDHIGFYRVNYEVATWDSIATALS--LNHKTFSSADRASLIDDAFALARAQLLD 672

  Fly   710 YETAMNLTRYLGHELGHVPWKAAISNFIFIDSMFVNSGD-YDLLKNYLLKQLKKVYDQVGFKDSQ 773
            |:.|:|||:||..|...:||:..||...:|.|||.:..: |.:::.|...|:|.:.|.:|:.|:.
Human   673 YKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWNDAG 737

  Fly   774 DESEDILVKLKRADILSMACHLGHQECIAEASRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQ- 837
            |.    :.||.|:.:|..||.:|.:|.:..||..|:.|:   |...:.|:  |||.:||...:|
Human   738 DH----VTKLLRSSVLGFACKMGDREALNNASSLFEQWL---NGTVSLPV--NLRLLVYRYGMQN 793

  Fly   838 YGTEYEWDFAFERFLKTNVPGEKDLLLNALGCSKEPWLLYRFLRRGISGQHIRKQDLFRVFAAVS 902
            .|.|..|::..|::.||::..||:.||..|...|...||.|:|........|:.||:|.|...:|
Human   794 SGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYIS 858

  Fly   903 TTVVGQNIAFDFLRNNWQEI---KTYMGSQMSSIHTLFKFATKGFNSKFQLGEFENFVKDAHWDY 964
            ....|:|:|:::::.||..:   .|.....:..|.|:    .:.||::.||.:.|:|.  |.:..
Human   859 YNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTI----AEPFNTELQLWQMESFF--AKYPQ 917

  Fly   965 ----DRPVQQIVEHIETSVDWMNKNYKSIVRWLEN 995
                ::|.:|::|.::.:::|:.::..:|..|..|
Human   918 AGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFN 952

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
superdeath	NP_651674.3	M1_APN-Q_like	121..571	CDD:341064	167/461 (36%)
		ERAP1_C	651..976	CDD:463368	106/333 (32%)
ENPEP	NP_001968.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	44..83		7/38 (18%)
		M1_APN-Q_like	100..540	CDD:341064	167/461 (36%)
		ERAP1_C	616..934	CDD:463368	106/353 (30%)