DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14516 and ENPEP

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_001968.3	Gene:	ENPEP / 2028	HGNCID:	3355	Length:	957	Species:	Homo sapiens

Alignment Length:	1010	Identity:	318/1010 - (31%)
Similarity:	523/1010 - (51%)	Gaps:	119/1010 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 KGGRRYSVSLTTAILLASFFICTLLAVGFIVYNFATCAELEPDSDEDVVCTSYHLRRLKAGHDDT 105
            :|.:||.:......:|.:..:...|.||..|....:| :...|..........||....|.....
Human     7 EGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSC-DSSGDGGPGTAPAPSHLPSSTASPSGP 70

  Fly   106 PKYDRDV--------------RLPHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLEDCYNITM 156
            |..|:|:              |||..:.|:.|::.::|.|..: |:.|:|.|.|.:......:.:
Human    71 PAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEED-TYTGTVSISINLSAPTRYLWL 134

  Fly   157 HAEELNISRSDASVHRVQNNGEPEGDGLRIHKQYLVGAKQFFVIELYDKLLK---DVEYVVHLRF 218
            |..|..|:       |:.....|.||.:::.:.:....:::.|:|..::|..   |..|::.:.|
Human   135 HLRETRIT-------RLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEF 192

  Fly   219 DGIIEDYLQGFYRSSYEVHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTIS 283
            .|.:...|.||||::|..:.:.:.:.:|..:.||||::|||||||..||.:|:.|..|:....:|
Human   193 AGWLNGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALS 257

  Fly   284 NMPIV---SSNDHATMPSYVWDHFAESLPMSTYLVAYAISDFTHI----SSGN-FAVWARADAIK 340
            |||:.   |.:|..|..:     |.:|:|||||||.:|:..|..:    :||. ..::.:.:...
Human   258 NMPVAKEESVDDKWTRTT-----FEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKH 317

  Fly   341 SAEYALSVGPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATAN 405
            :||||.::...:..:.:::|.:.:.|||:|.||:|:|..||||||||||:|||.:||||..:.::
Human   318 TAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASS 382

  Fly   406 NKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQA 470
            |:||||:||.|||.||||||:||..||.|:||||||||:.|:|..:....:|:..||.::.::..
Human   383 NQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLP 447

  Fly   471 VFQLDALSTSHKISHEVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYN 535
            |.:.|:|.:||.|...|..|.||:.:||.|||:|||:|:||:..::....|::|...||::..:.
Human   448 VQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFK 512

  Fly   536 SATQDDLWHFLTVEAKSSGLLDDSR-SVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVY- 598
            :|...|.|         :.|.:.|| .|||:|||||.|.||||:.|     :.|..:.|.||:.
Human   513 NAKTSDFW---------AALEEASRLPVKEVMDTWTRQMGYPVLNV-----NGVKNITQKRFLLD 563

  Fly   599 --TNTTR--EDESLLWYIPITFTTDS---------------ELNFANTRPTTWMPRTKLYELENR 644
              .|.::  .|....|.||:.:|.|:               .||.:|.....::.
Human   564 PRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLK---------- 618

  Fly   645 ELSLAKWFIFNVQQTGYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLS 709
                     .|....|:|||||::..|.:|...|.  .|.:..:.|:||.||||...|||...|.
Human   619 ---------INPDHIGFYRVNYEVATWDSIATALS--LNHKTFSSADRASLIDDAFALARAQLLD 672

  Fly   710 YETAMNLTRYLGHELGHVPWKAAISNFIFIDSMFVNSGD-YDLLKNYLLKQLKKVYDQVGFKDSQ 773
            |:.|:|||:||..|...:||:..||...:|.|||.:..: |.:::.|...|:|.:.|.:|:.|:.
Human   673 YKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWNDAG 737

  Fly   774 DESEDILVKLKRADILSMACHLGHQECIAEASRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQ- 837
            |.    :.||.|:.:|..||.:|.:|.:..||..|:.|:   |...:.|:  |||.:||...:|
Human   738 DH----VTKLLRSSVLGFACKMGDREALNNASSLFEQWL---NGTVSLPV--NLRLLVYRYGMQN 793

  Fly   838 YGTEYEWDFAFERFLKTNVPGEKDLLLNALGCSKEPWLLYRFLRRGISGQHIRKQDLFRVFAAVS 902
            .|.|..|::..|::.||::..||:.||..|...|...||.|:|........|:.||:|.|...:|
Human   794 SGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYIS 858

  Fly   903 TTVVGQNIAFDFLRNNWQEI---KTYMGSQMSSIHTLFKFATKGFNSKFQLGEFENFVKDAHWDY 964
            ....|:|:|:::::.||..:   .|.....:..|.|:    .:.||::.||.:.|:|.  |.:..
Human   859 YNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTI----AEPFNTELQLWQMESFF--AKYPQ 917

  Fly   965 ----DRPVQQIVEHIETSVDWMNKNYKSIVRWLEN 995
                ::|.:|::|.::.:::|:.::..:|..|..|
Human   918 AGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFN 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	148/402 (37%)
		M1_APN_2	121..576	CDD:189008	170/466 (36%)
		ERAP1_C	652..974	CDD:288671	105/330 (32%)
ENPEP	NP_001968.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..83		7/38 (18%)
		Peptidase_M1	92..482	CDD:279741	148/402 (37%)
		M1_APN_2	100..545	CDD:189008	170/466 (36%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:23888046, ECO:0007744\|PDB:4KXA, ECO:0007744\|PDB:4KXB, ECO:0007744\|PDB:4KXC, ECO:0007744\|PDB:4KXD	357..361		3/3 (100%)
		ERAP1_C	617..931	CDD:288671	105/349 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3793
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.850