DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14516 and Npepps

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_032968.2	Gene:	Npepps / 19155	MGIID:	1101358	Length:	920	Species:	Mus musculus

Alignment Length:	908	Identity:	277/908 - (30%)
Similarity:	467/908 - (51%)	Gaps:	78/908 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 RLPHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLEDCYNITMHAEELNI------SRSDASVH 171
            |||..:.|:.|::.::|.|. :|||.|.::...:|.:....|.|:..:::|      ...|..:|
Mouse    54 RLPAEVSPINYSLCLKPDLL-DFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIH 117

  Fly   172 RVQNNGEPEGDGLRIHKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQGFYRSSYEV 236
            ....|.:.|.:.:.:.               :...|:.....:.:.|.|.:.|.::|||||.|..
Mouse   118 ATGFNYQNEDEKVTLS---------------FPSTLQTGTGTLKIDFVGELNDKMKGFYRSRYTT 167

  Fly   237 -HNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSSNDHATMPSYV 300
             ..|.|:.|.|||:||||||||||:||||:||.|.:.:..|::...:|||.::....:....:.|
Mouse   168 PAGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLV 232

  Fly   301 WDHFAESLPMSTYLVAYAISDFTHISSGN-----FAVWARADAIKSAEYALSVGPRILTFLQDFF 360
            ...||.:..|||||||:.:.::..:.:.:     ..|:......:..::||.|..:.|.|.:|:|
Mouse   233 EVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYF 297

  Fly   361 NVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQWFGN 425
            ||.:||||||:||:.:|.|||||||||:|:||||:|.||..:.::::|.||.|||||||||||||
Mouse   298 NVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGN 362

  Fly   426 LVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDALSTSHKISHEVFNP 490
            |||..||:.:||||||||::|||..|...||:....|||..:.....:||||..||.|...|.:|
Mouse   363 LVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHP 427

  Fly   491 QEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLWHFLTVEAKSSGL 555
            .|:.||||.|||:||:::|||:..::.:..|::|::.||.:....:|..:|||..|   ..:||
Mouse   428 SEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESL---ESASG- 488

  Fly   556 LDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSD--VIRLEQVRFVYTNTTREDESLLWYIPITFTT 618
                :.:..:|:|||.|.|:|::.|......|  |::|.|.:|..:.....::...|.:|||.:|
Mouse   489 ----KPIAAVMNTWTKQMGFPLIYVEAEQVEDDRVLKLSQKKFCASGPYGGEDCPQWMVPITIST 549

  Fly   619 DSELNFANTRPTTWMPRTKLYELENRELSLA-------KWFIFNVQQTGYYRVNYDLENWMAITE 676
            ..:.|.|         :.|:. ::..|:|:.       :|...|:...|:||..|.    .|:.|
Mouse   550 SEDPNQA---------KLKIL-MDKPEMSVVLKNVKPDQWVKLNLGTVGFYRTQYS----SAMLE 600

  Fly   677 HLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAISNFIFIDS 741
            .|:.......:.|.:|..|.:|:.:|||...:|....:.:.....:|..:..|.....|...:.:
Mouse   601 SLLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILST 665

  Fly   742 MFVNSGDYDLLKNYLLKQLKKVYDQVGFKDSQD--ESEDILVKLKRADILSMACHLGHQECIAEA 804
            :..::..|:.::.:    :|.|:..:|.:...|  ..|..|..|.|..:|......||:..:.||
Mouse   666 LLSHTDFYEEIQEF----VKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEA 726

  Fly   805 SRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQYGTEYEWDFAFERFLKTNVPGEKDLLLNALGC 869
            .|.|:.     :.:....:..:||..||.:.:::|.....|...:...:.::..||:.:...||.
Mouse   727 RRRFKE-----HVEGKQILSADLRSPVYLTVLKHGDGATLDIMLKLHKQADMQEEKNRIERVLGA 786

  Fly   870 SKEPWLLYRFLRRGISGQHIRKQDLFRVFAAVS-TTVVGQNIAFDFLRNNWQEI-KTYMGSQMSS 932
            :..|.|:.:.|...:| :.:|.||...|...|: .:..|:..|:.|:::||:|: ..|.|..:
Mouse   787 TLSPELIQKVLTFALS-EEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELHNRYQGGFL-- 848

  Fly   933 IHTLFKFATKGFNSKFQLGEFENFVKDAH--WDYDRPVQQIVEHIETSVDWMNKNYKSIVRWL 993
            |..|.|.:.:||......||.:.|. ::|  ...:|.:||..|:|..:..|:.::..||.::|
Mouse   849 ISRLIKLSVEGFAVDKMAGEVKAFF-ESHPAPSAERTIQQCCENILLNAAWLKRDADSIHQYL 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	157/403 (39%)
		M1_APN_2	121..576	CDD:189008	175/466 (38%)
		ERAP1_C	652..974	CDD:288671	74/327 (23%)
Npepps	NP_032968.2	Peptidase_M1	54..442	CDD:279741	157/403 (39%)
		M1_APN_2	62..505	CDD:189008	175/466 (38%)
		Substrate binding. /evidence=ECO:0000250	317..321		3/3 (100%)
		ERAP1_C	580..891	CDD:288671	74/327 (23%)
		Nuclear localization signal. /evidence=ECO:0000255	727..731		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820