Protein Alignment CG14516 and AC3.5

DIOPT Version :9

• Sequence 1: NP_651674.3
• Gene: CG14516 / 43444
• FlyBaseID: FBgn0039640
• Length: 999
• Species: Drosophila melanogaster
• Sequence 2: NP_001256214.1
• Gene: AC3.5 / 179447
• WormBaseID: WBGene00007071
• Length: 1090
• Species: Caenorhabditis elegans
• Alignment Length: 1089
• Identity: 232/1089 - (21%)
• Similarity: 445/1089 - (40%)
• Gaps: 156/1089 - (14%)

  Fly    15 IPLHENL---NMESRPMNAATPTTTTTFS------KGGRRYSVSLTTAILLASFFICTLLAVGFI 70
            |||.|..   .::::|.. |.|.......      |..:|.:.|..:||.|      .||||..|
 Worm    34 IPLSEKAAKEPLQTQPQE-APPAPKPKVQKQKPPVKPKKRIACSPGSAICL------FLLAVAAI 91

  Fly    71 VY-----NFATCAELE----PDSDEDVVCTSYHLRRLKAGHDDTPKYDRD------------VRL 114
            ::     ::.|....|    ..::|.:.......|..|...|...:.|.|            :.|
 Worm    92 IFAAFLGHYLTKQNYEMMQFKSANESMTTCKNFTRSHKKHQDIVNEEDADENASIKQPTKEELAL 156

  Fly   115 PHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLEDCYNITMHAEELNISRSDASVHRVQNNGE- 178
            |.:::|:.|::::.|::.||.|. |...:::.:.|....|.::|:::..:|   ::.::|.:.|
 Worm   157 PKNVQPVWYDVSLSPKVGGNGTM-GLAHVKLNIEEPTNKIVLNAKDIEFTR---NLEKIQLSKEV 217

  Fly   179 ------------------PEGDG----------------LRIHKQYLVGAK----------QFFV 199
                              |||.|                ..:......|.|          :...
 Worm   218 TKRAKKSVDSGTNSTSEMPEGSGEEAMATTATTTTTESTTPVSSFVDTGIKVTNIEFDENLEKVT 282

  Fly   200 IELYDKLLKDVEYVVHLRFDGIIEDY--LQGF-YRSSYEVHNETRWVASTQFQATDARRAFPCFD 261
            :.|..:|.|....|:.:.|...:.:.  |:.: |::|   ..:.:.:.:||...:..|..||.||
 Worm   283 LTLDQELKKGSTVVLKIPFTSKVSNNNGLKEYKYKNS---EGKEQSMFTTQPSYSYLRHVFPSFD 344

  Fly   262 EPALKANFTLHIARPRNMTTISNMPIVSSNDHATMPSYVWDHFAESLPMSTYLVAYAISDFTHIS 326
            :.|.||...:.:...:....::|..:.:.:|.....|.:     ..:....:::...::...:.:
 Worm   345 QEAFKAPAAITLMHSKGSIVVANTGVKTKDDGDAQTSTL-----NKVLDPDFVIGDLVASEVNTT 404

  Fly   327 SG-NFAVWARADAIKSAEYALSVGPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITF 390
            || ...:|.|.:...|.|.:|....:.:..::...........:|::|:|.||.|...:...|..
 Worm   405 SGITIRIWTRPEVKHSTEQSLDYANQAIDAMEHILQSRLESKSLDIVAVPGFQTGNRVSPSFIVL 469

  Fly   391 RETAMLYDPGVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAP 455
            .|..:||:......|.|.|:|.::.:.:|.||||.:..|..:...||||....::|....:.:..
 Worm   470 PEEDILYNEQSNDINQKTRIARMISNRIAAQWFGGITNPEEFGTFWLNEALPRFLEVEALEKILD 534

  Fly   456 EWKQLDQFVVNELQAVFQLDALSTSHKIS-HEVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNP 519
              ...|.....|::.:.:.||.:||..:. ..||:..:|:||.......||:.::||:...:...
 Worm   535 --INSDDLWTYEMEKILERDATATSQPLRVKNVFSSADIAEIDHEFIGKKGAAVLRMIQKSVGVN 597

  Fly   520 IFRRGLSKYLQEMAYNSA--TQDDLWHFL--TVEAKSSGLLDDSRSVKEIMDTWTLQTGYPVVKV 580
            :|.:.:..::.  :|.||  ..|.||...  .:..|..|..::...|.:.::||..|.|:|:|.|
 Worm   598 VFNKAIRSFVS--SYRSAYPYDDGLWKSFEKALGGKLKGWNNEPLDVAKFVNTWVDQIGFPLVSV 660

  Fly   581 SRHPNSDVIRLEQVRFVYTNTTREDESLL-------WYIPITFTTDSELNFANTRPTTWMPRTKL 638
            .: .:.:.:.|.|.||...:.|:|.....       |.:|:...:...:.     ..:|     |
 Worm   661 EK-LDDETVELSQERFKNDHKTKEQFKFRNAKYWFNWEVPLFLKSSGPVG-----NVSW-----L 714

  Fly   639 YELENRELSLAKWFIFNVQQTGYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLA 703
            :|.....|:.:.....|....|.|||||:.:.|..|.:.|  ..:...::...||:||.||..||
 Worm   715 HEAFRLPLNTSDSIYLNTDSNGVYRVNYEEKRWNDIAKQL--EKSHGKLSERTRARLISDVFALA 777

  Fly   704 RGSYLSYETAMNLTRYLGHELGHVPWKAAISNFIFIDSMFVNSGDYDLLKNYLLKQLKKVYDQVG 768
            ....|.:|||:|:|.||..|...|||..|...|..:......:...|.|.:::.:::.|.::::.
 Worm   778 NSGALPFETALNVTSYLPMETATVPWLIATRIFKKLTERLEGAPIQDKLNSFIYQKIHKKFEEIS 842

  Fly   769 FKDSQDESEDILVKLKRADILSMACHLGHQECIAEASRHFQNWMQTP-----NPDSNNPIVP-NL 827
            ....:..|..:..:| .|::|.:...:..::...:.:..|......|     |..|:...|| :|
 Worm   843 SSPGEASSNYLKNRL-YANLLDLMAIVKPEKSNEKLNELFVEGFLAPCQFSGNFSSDCSEVPGDL 906

  Fly   828 RGVVYCSAIQYGTEYEWDFAFE---RFLKTNVPG-EKDLLLNALGCSKEPWLLYRFLRRGISGQH 888
            |..|||:.:::|.    |..||   ...:..|.| |||||.|:|.|.::|    |.|||.|....
 Worm   907 REKVYCNGVEFGN----DTVFETVRELAEKEVDGAEKDLLQNSLACFRDP----RALRRLILDNL 963

  Fly   889 IRKQDLFRVFAAVSTTVVGQNIAFDFLRNNWQEI--KTYMGSQMSSIHTLFKFATKG--FNSKFQ 949
            .....:..:...:::..||:.||.:::.:||..:  |.:....    .||...|..|  .:::.:
 Worm   964 NSTSTVTLLLRKMNSRPVGKEIATNWIIDNWSTVLKKKFKNDP----ETLNAIADAGIILDNERE 1024

  Fly   950 LGEFENFVKDAHWDYD--RPVQQIVEHIETSVDWMNKNYKSIVRWLENE 996
            ....|.|::..|....  ..:.:.:|...|.:.|..:....:..:|:.:
 Worm  1025 KSMIETFMEHHHKSTHGIESLDKKIEEATTDIYWRKQKINELNDYLDGK 1073

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	85/441 (19%)
		M1_APN_2	121..576	CDD:189008	100/508 (20%)
		ERAP1_C	652..974	CDD:288671	84/337 (25%)
AC3.5	NP_001256214.1	Peptidase_M1	156..574	CDD:279741	83/431 (19%)
		GluZincin	165..656	CDD:301352	100/506 (20%)
		ERAP1_C	728..1052	CDD:288671	85/338 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020