DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14516 and ltah-1.1

DIOPT Version :9

Sequence 1:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_001023056.1	Gene:	ltah-1.1 / 178176	WormBaseID:	WBGene00016589	Length:	609	Species:	Caenorhabditis elegans

Alignment Length:	680	Identity:	150/680 - (22%)
Similarity:	249/680 - (36%)	Gaps:	181/680 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 PKYDRD---------VRLPHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLEDCYNITMHAEEL 161
            |.:.||         |.:.|  ..||:.:..|.:     ..||.|.|.:.|.:|...|.:...:|
Worm     3 PPHPRDPSTAANYEQVTVSH--YALKWKVDFEKK-----HIAGDVSITLDVKQDTERIVLDTRDL 60

  Fly   162 NISRSDASVHRVQNNGEPEGDGLRIHKQYLVGAKQFFVIELY---DKLLKDVEY-----VVHLRF 218
            ::.....::     ||||:..|..:.....:|.|.....|..   |:.:.:::|     ...|:|
Worm    61 SVQSVALNL-----NGEPKKAGFTLEDNQALGQKLVITTESLKSGDRPVLEIKYESSNNAAALQF 120

  Fly   219 DGIIEDYLQGFYRSSYEVHNETRWVAS---TQFQATDARRAFPCFDEPALKANFTLHIARPRNMT 280
                           ......|..||.   :|.||.:||...||.|.|::|:.:...:..|..:|
Worm   121 ---------------LTAEQTTDRVAPYLFSQCQAINARSIVPCMDTPSVKSTYEAEVCVPIGLT 170

  Fly   281 TISNMPIVSSNDHATMPSYVWDH----FAESLPMSTYLVAYAISDFTHIS----SGNFAVWARAD 337
            .     ::|:....:.||.....    |.:.:.:.:||:|..:.   |:.    |...||||...
Worm   171 C-----LMSAIGQGSTPSECGKRTIFSFKQPVSIPSYLLAIVVG---HLERKEISERCAVWAEPS 227

  Fly   338 AIKSAEYALSVGPRILTFLQDFFNVTFPL--PKIDMIALP-EFQAGAMENWGLITFRETAMLYDP 399
            ..:::.|..:...:||...:|   |..|.  .:.|::.|| .|..|.|||..|.....|.:..|
Worm   228 QAEASFYEFAETEKILKVAED---VAGPYVWGRYDLVVLPATFPFGGMENPCLTFITPTLLAGD- 288

  Fly   400 GVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFV 464
                    :.:.:|:.||::|.|.|||||...|...||||||..::|           :::...:
Worm   289 --------RSLVNVIAHEISHSWTGNLVTNFSWEHFWLNEGFTVFLE-----------RKIHGKM 334

  Fly   465 VNELQAVFQL-----DALSTSHKISHEVFNPQ-------------EISEIFDRISYAKGSTIIRM 511
            ..||:..|:.     :||.   :..::||.|.             :..:.|..:.|.|||.::..
Worm   335 YGELERQFESESGYEEALV---RTVNDVFGPDHEYTKLVQNLGNADPDDAFSSVPYEKGSALLFT 396

  Fly   512 MAHFL-TNPIFRRGLSKYLQEMAYNSATQDDLWHFLTVEAKSSGLLDDSRSVKEIMDT-----WT 570
            :...| .|..|.:.|..|:|:.||.:.:.:: |        ...|.|.....|.|:|.     |.
Worm   397 IEQALGDNSRFEQFLRDYIQKYAYKTVSTEE-W--------KEYLYDSFTDKKVILDNIDWNLWL 452

  Fly   571 LQTGYPVVKVSRHPNSDVIRLEQVRFVYTNTTREDESLLWYIPITFTTDSE-------------L 622
            .:.|.|     ..|..|...::..:.:....|.|....        .||.|             |
Worm   453 HKAGLP-----PKPKYDSTPMQACKDLAAKWTTEGSEA--------PTDGEVFAKMSNSQKLAVL 504

  Fly   623 NFANTRPTTW---MPR-TKLYELE---NRELSLA--------KW---------FIFNVQQTGYYR 663
            :......|.:   ||. |..|:|:   |.||..:        ||         |...|.:..|.:
Worm   505 DAVRVNKTMFGDRMPALTATYKLDQAKNAELKFSWLMLGLETKWSPIVDASLAFALAVGRMKYCK 569

  Fly   664 VNY-DLENW-----MAITEHLMDVDNFEDI 687
            ..| .|..|     .||::...::.|...|
Worm   570 PIYRSLFGWSATRDRAISQFKANIPNMHPI 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	97/431 (23%)
		M1_APN_2	121..576	CDD:189008	115/500 (23%)
		ERAP1_C	652..974	CDD:288671	10/42 (24%)
ltah-1.1	NP_001023056.1	M1_LTA4H	8..453	CDD:189006	117/514 (23%)
ltah-1.1	NP_001023056.1	Leuk-A4-hydro_C	468..608	CDD:312599	27/140 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910