Protein Alignment superdeath and Lnpep

DIOPT Version :10

• Sequence 1: NP_651674.3
• Gene: superdeath / 43444
• FlyBaseID: FBgn0039640
• Length: 999
• Species: Drosophila melanogaster
• Sequence 2: NP_001106874.1
• Gene: Lnpep / 171105
• RGDID: 621752
• Length: 1025
• Species: Rattus norvegicus
• Alignment Length: 1016
• Identity: 317/1016 - (31%)
• Similarity: 506/1016 - (49%)
• Gaps: 115/1016 - (11%)

  Fly    21 LNMESRPMNAAT-----PTTTTTFSKGGRRYSVSLTTAILLASFFICTLLAVGFIVYNFATC--- 77
            :|..|...|:||     |..|.         ||.....:::..|.|...::|..::|....|
  Rat    82 MNRSSGLRNSATGYRQSPDGTC---------SVPSARTLVICVFVIVVAVSVIMVIYLLPRCTFT 137

  Fly    78 ----------AEL-EPDSDEDVVCTSYHLRRLKAGHDDTPKYDRDVRLPHSIRPLKYNITIEPQL 131
                      ||| :|.:....|...                 ..:|||.:|.|.:|.:::.|.|
  Rat   138 KEGCHKTNQSAELIQPIATNGKVFPW-----------------AQIRLPTAIIPQRYELSLHPNL 185

  Fly   132 SGNFTFAGSVQIRIRVLEDCYNITMHAEELNISRSDASVHRVQNNGEPEGDGLR--IHKQYLVGA 194
            : :.||.|||.|.::.|:|..:|.:|:...||  |..:.....::.|.:.:.|.  .|:|..|.|
  Rat   186 T-SMTFRGSVTISLQALQDTRDIILHSTGHNI--SSVTFMSAVSSQEKQVEILEYPYHEQIAVVA 247

  Fly   195 KQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQGFYRSSY-EVHNETRWVASTQFQATDARRAFP 258
            .        :.||....|.:.:.:...|.:...|||..:| :..||.:..|:|||:...||.|||
  Rat   248 P--------ESLLTGHNYTLKIEYSANISNSYYGFYGITYTDKSNEKKNFAATQFEPLAARSAFP 304

  Fly   259 CFDEPALKANFTLHIARPRNMTTISNMPIVSSNDHATMPSYVWDHFAESLPMSTYLVAYAISDFT 323
            ||||||.||.|.:.|.|..:.|.:||||..||  ..|....:.|.|:||:.|||||||:.:.:..
  Rat   305 CFDEPAFKATFIIKITRDEHHTALSNMPKKSS--VPTEEGLIQDEFSESVKMSTYLVAFIVGEMR 367

  Fly   324 HIS---SGNF-AVWARADAIKSAEYALSVGPRILTFLQDFFNVTFPLPKIDMIALPEFQAGAMEN 384
            ::|   :|.. :|:|..:.|....:||....::|.|.|::|.:.:||.|:|::|:|:|:||||||
  Rat   368 NLSQDVNGTLVSVYAVPEKIDQVYHALDTTVKLLEFYQNYFEIQYPLKKLDLVAIPDFEAGAMEN 432

  Fly   385 WGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLT 449
            |||:||||..:|||...::..:::.|..::.|||||||||||||..||:|:|||||||::|||.:
  Rat   433 WGLLTFREETLLYDNATSSVADRKLVTKIIAHELAHQWFGNLVTMQWWNDLWLNEGFATFMEYFS 497

  Fly   450 ADAVAPEWKQLDQFVVNELQAVFQL---DALSTSHKISHEVFNPQEISEIFDRISYAKGSTIIRM 511
            .:.:..|....:.|    |.|.|:.   |:|::||.||..|.:.::|.|:||.:||.||::::.|
  Rat   498 VEKIFKELNSYEDF----LDARFKTMRKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGASLLLM 558

  Fly   512 MAHFLTNPIFRRGLSKYLQEMAYNSATQDDLW-HFLTVEAKSSGLLDDSRSVKEIMDTWTLQTGY 575
            :..:|:..:|:..:..||...:|.:...|||| .|..|..|:   ||    ||::|.|||||.|:
  Rat   559 LKSYLSEDVFQHAIILYLHNHSYAAIQSDDLWDSFNEVTGKT---LD----VKKMMKTWTLQKGF 616

  Fly   576 PVVKVSRHPNSDVIRLEQVRF---VYTNTTREDESLLWYIPITFTTDSELNFANTRPTTWMPRTK 637
            |:|.|.|  ....:.|:|.||   :.......|.|.||:|||::.||.. |::..|..:
  Rat   617 PLVTVQR--KGTELLLQQERFFPSMQPEIQDSDTSHLWHIPISYVTDGR-NYSEYRSVS------ 672

  Fly   638 LYELENRELSL---AKWFIFNVQQTGYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLIDDV 699
            |.:.::..::|   .:|...|...||||.|:|..:.|.|:...|.  .|...::..:||.||:::
  Rat   673 LLDKKSDVINLTEQVQWVKVNTNMTGYYIVHYAHDGWAALINQLK--RNPYVLSDKDRANLINNI 735

  Fly   700 MNLARGSYLSYETAMNLTRYLGHELGHVPWKAAISNFIFIDSMFVNSGDYDLLKNYLLKQLKKVY 764
            ..||....:..:.|.:|..||.:|....|...|:.....|.::....|..||....:.:..|.:.
  Rat   736 FELAGLGKVPLQMAFDLIDYLRNETHTAPITEALFQTDLIYNLLEKLGHMDLSSRLVTRVHKLLQ 800

  Fly   765 DQVGFKDSQDESEDILVKLKRADILSMACHLGHQECIAEASRHFQNWMQTPNPDSNNPIVPNLRG 829
            :|:..:...||....:.:|:.| :|..||....:.|...|::.|..||.:....|       |..
  Rat   801 NQIQQQTWTDEGTPSMRELRSA-LLEFACAHSLENCTTMATKLFDGWMASNGTQS-------LPT 857

  Fly   830 VVYCSAIQYG--TEYEWDFAFERFLKTNVPGEKDLLLNALGCSKEPWLLYRFLRRGISGQHIRKQ 892
            .|..:..:.|  ||..|.|.|..:.......|||.:|.||..|.:...||..::..:.|..||.|
  Rat   858 DVMTTVFKVGARTEKGWLFLFSMYSSMGSEAEKDKILEALASSADAHKLYWLMKSSLDGDIIRTQ 922

  Fly   893 DLFRVFAAVSTTVVGQNIAFDFLRNNWQEI--KTYMGSQMSSIHTLFKFATKGFNSKFQLGEFEN 955
            .|..:...|.....|..:|:||::.||.::  |.::||.  :|.::...:|..|::|..|.|.:.
  Rat   923 KLSLIIRTVGRQFPGHLLAWDFVKENWNKLVHKFHLGSY--TIQSIVAGSTHLFSTKTHLSEVQE 985

  Fly   956 FVK---DAHWDYDRPVQQIVEHIETSVDWMNKNYKSIVRWL 993
            |.:   :|.... |.||:..|.||.::.||.:|.|::..||
  Rat   986 FFENQSEATLQL-RCVQEAFEVIELNIQWMARNLKTLTLWL 1025

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
superdeath	NP_651674.3	M1_APN-Q_like	121..571	CDD:341064	172/460 (37%)
		ERAP1_C	651..976	CDD:463368	88/331 (27%)
Lnpep	NP_001106874.1	Dileucine internalization motif. /evidence=ECO:0000255	53..54
		Dileucine internalization motif. /evidence=ECO:0000255	76..77
		Tankyrase binding. /evidence=ECO:0000250	96..101		1/4 (25%)
		M1_APN-Q_like	176..612	CDD:341064	172/459 (37%)
		ERAP1_C	689..1009	CDD:463368	89/332 (27%)